The mt-DNA mutator mouse

我们正在描述由mtDNA突变水平升高引起的CNS表型，并将这些发现与年龄相关的功能变化联系起来。 此外，我们将研究缺血性脑损伤对这些小鼠的影响。我们已经记录了皮质厚度和分层模式的变化。氧化能产生和线粒体功能也发生变化。这些变化与mtDNA突变子中的认知和运动缺陷平行。正在评估上调线粒体功能的药物。

We are characterizing the CNS phenotypes caused by elevated mtDNA mutation levels and relating these findings to age-related functional changes. Furthermore, we will investigate the affects of ischemic brain injury in these same mice. We have already documented change in cortical thickness and lamination patterns. There are also changes in oxidative energy production and mitochondrial function. These changes parallel cognitive and motor deficiencies in the mtDNA mutators. Drugs that upregulate mitochondrial function are being evaluated.