Studies on CDNF: a new class of neurotrophic proteins

我们研究了CDNF蛋白在大鼠单侧最大损毁PD 6-OHDA模型中的作用。在脑内注射6-OHDA前和注射后两周分别给予CDNF，研究CDNF蛋白在双亲注射MPTP诱导的小鼠双侧帕金森病模型中的作用。我们研究了CDNF蛋白在MitoPark小鼠模型中的作用。我们正在开发一种小鼠CDNF零突变，并将研究中脑DA系统的发展。我们将产生AAV-CDNF，以便在6-OHDA大鼠模型以及MPTP和MitoPark小鼠模型中测试效果。如果成功制造出这样的载体，将在未来的研究中进行体内测试。

We study effects of CDNF protein in the rat unilateral maximal lesion PD 6-OHDA model. CDNF is administered prior to, and two weeks after, intracranial injection of 6-OHDA into the ascending DA bundle.We study effects of CDNF protein in the mouse bilateral PD model induced by parental injection of MPTP. We study effects of CDNF protein in the MitoPark mouse model. We are developing a mouse CDNF null mutation and will study development of the midbrain DA system. We will generate AAV-CDNF and in order to test effects in the 6-OHDA rat model and in the MPTP and MitoPark mouse models. In vivo tests of such a vector, if successfully generated, will be carried out in future research.