Problem Solving in Transplant Patients and Caregivers

本研究旨在测试问题解决教育干预在异体造血干细胞移植（HSCT）患者和家庭护理人员中的潜在应用。增加解决问题的能力已被证明可以减少痛苦，并可能改善症状痛苦和与健康相关的生活质量。准备家庭护理干预，也被称为COPE，已经证明对癌症患者及其家庭有益，但目前的应用存在局限性。只有一项研究报道了这种干预在急性护理环境中的应用，没有研究对接受造血干细胞移植的患者进行过研究。

This study is designed to test the potential application of a problem-solving education intervention for patients and family caregivers experiencing allogeneic hematopoietic stem cell transplantation (HSCT). An increase in problem-solving has been shown to decrease distress and may improve symptom distress and health related QOL. The Prepared Family Caregiving intervention, also known as COPE, has demonstrated benefit in cancer patients and their families, however there are limitations to its current application. Only one study has reported the application of this intervention in the acute care setting and no study has been done with patients undergoing HSCT. Subjects were accrued to this protocol once they have agreed to participate in an allogeneic HSCT at the Clinical Center, NIH. The study completed enrollment 1/2008. 34 dyads were screened for potential participation, 10 dyads (patient and caregiver, N = 20) were eligible and agreed to be enrolled. 24 dyads were in-eligibile due to non-English speaking/reading and inconsistent caregiver presence. Data are currently being analyzed. The results to this study will guide future research examining predictors and outcomes associated with problem solving education intervention as compared to usual care group education in dyads receiving allogeneic HSCT.