12th Biennial Graylyn Conference on Women's Cognitive Health

描述（由申请人提供）：女性特有疾病的治疗和预防是一个关键的研究领域，涵盖了从分子到社会、行为和经济端点的整个方法范围。这种广泛的科学努力正被用来确定与年龄相关的认知变化，这些变化发生在女性身上，并确定最有效的方法来防止女性认知能力下降。学科之间以及基础、临床和卫生服务科学家之间的相互作用将导致旨在增强认知健康的最有效的转化干预。维克森林大学健康科学（WFUHS）的妇女健康卓越研究、领导和教育中心（WHCoE）于1995年开始了一年一度的格雷林妇女健康会议，并于1997年建立了两年一次的格雷林妇女认知健康会议，以开展与妇女健康有关的前沿认知研究。2007年格雷林妇女认知健康会议探讨了激素治疗（HT）的具体问题和与妇女认知衰老有关的更广泛的问题。自那次会议以来，临床和基础科学研究继续以更好地理解妇女健康倡议记忆研究（WHIMS）和妇女健康倡议认知衰老研究（WHISCA）所获得的结果为目标，并更充分地探索旨在解决妇女年龄相关认知功能障碍的更广泛复杂问题的新方法。我们计划通过将于2009年举行的题为“通过创新转化研究改善妇女认知衰老轨迹”的第12届格雷林会议，继续在妇女认知健康领域的领导人之间进行这种关键和不断发展的对话。特邀演讲者将介绍并批判性地回顾从基础研究到临床研究和卫生服务研究的当前知识，以指导努力制定有关激素和其他治疗的创新研究议程，这些研究议程与提高妇女认知衰老的知识有关。与以往一样，本次会议规模相对较小（约100名与会者），演讲者将在主题领域提供尖端的科学报告。会议的重点将是研究从长凳到床边的社区政策和实践与翻译的焦点。会议将讨论如何加强包括多学科在内的转化对话，以及在分子、动物、人类研究、社区推广和循证医学水平实践方面确定妇女认知衰老研究的关键方向。

DESCRIPTION (provided by applicant): The treatment and prevention of diseases that are unique to women is a critical area of research that encompasses the entire spectrum of approaches from molecular to social, behavioral and economic endpoints. This breadth of scientific endeavors is being used to determine the age-related cognitive changes that occur in women and to identify the most effective approaches to prevent cognitive decline in women. Interactions among disciplines and between basic, clinical and health services scientists will lead to the most efficacious translational interventions designed to enhance cognitive health. The Women's Health Center of Excellence for Research, Leadership, Education (WHCoE) of the Wake Forest University Health Sciences (WFUHS) began annual Graylyn Conferences of Women's Health in 1995 and in 1997 established the biennial Graylyn Conferences on Women's Cognitive Health for cutting-edge cognitive research related to women's health. The 2007 Graylyn Conference on Women's Cognitive Health explored issues specific to hormone therapy (HT) and broader issues related to women's cognitive aging. Since that meeting, clinical and basic science research has continued the goal of better understanding the results obtained in the Women's Health Initiative Memory Study (WHIMS) and the Women's Health Initiative Study of Cognitive Aging (WHISCA) and more fully exploring novel approaches designed to address the broader complex questions of age-related cognitive dysfunction in women. We plan to continue this critical and evolving dialogue among leaders in the field of women's cognitive health through the12th Graylyn Conference to be held in 2009 entitled "Improving the Trajectory of Cognitive Aging in Women through Innovative Translational Research". Invited speakers will present and critically review the current knowledge from basic to clinical research and health services research in order to guide efforts toward developing an innovative research agenda about hormonal and other therapies relevant to the advancement of knowledge in women's cognitive aging. As in the past, this conference will be relatively small (about 100 attendees) with speakers providing cutting-edge scientific presentations in themed areas. The emphasis of conference sessions will be on research from bench to bedside to community policy and practice with a translational focus. Discussions will be on how to enhance translational dialogues that include multiple disciplines, and on identifying the key directions for research on women's cognitive aging at the molecular, animal, human studies, and community outreach and practice of evidence-based medicine levels. PUBLIC HEALTH RELEVANCE: Among women, cognitive aging is a critical concern that has social impact on the individual, her family, as well as an enormous economic impact. Enhancing our understanding of the problems associated with cognitive aging would assist in addressing this growing concern. This conference enables investigators from various disciplines worldwide to tackle the problem by developing new mechanisms to detect cognitive decline and develop promising treatments that may delay the onset and progression of the symptoms associated with dementia.