Women's Health Initiative Memory Study (WHIMS)

女性健康倡议记忆研究 (WHIMS)

• 批准号: 7824221
• 负责人: Sally Ann SHUMAKER
• 金额: $ 180.62万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7824221
• 关键词: Women; Health; Initiative; Memory; Study

Beginning in 1996, the WHI Memory Study (WHIMS) enrolled participants from the WHI hormone trials to test whether hormone therapy prevented cognitive decline, mild cognitive impairment, and probable dementia (including Alzheimer's disease). After the WHI hormone trials were stopped early, previous industry funding was withdrawn. NHLBI agreed to 4 years of funding to complete the Estrogen-Alone trial; continue monitoring post-trial cognitive health; and perform brain MRI scans to elucidate the role of vascular disease. Given the findings to date, the increasing population dementia burden, and the need to study its causes using both classic epidemiologic methods and new technologies, NHLBI extended this project in 2008 in order to fully leverage this unique resource.

从1996年开始，WHI记忆研究(Whims)从WHI激素试验中招募参与者，以测试激素治疗是否可以防止认知下降、轻度认知障碍和可能的痴呆症(包括阿尔茨海默病)。在WHI激素试验提前停止后，之前的行业资金被撤回。NHLBI同意提供4年的资金，以完成雌激素单独试验；继续监测试验后的认知健康；并进行脑MRI扫描，以阐明血管疾病的作用。 鉴于迄今为止的研究结果、日益加重的人口痴呆症负担，以及需要使用经典流行病学方法和新技术研究其原因，NHLBI于2008年延长了这一项目，以充分利用这一独特的资源。