Women's Health Initiative Memory Study (WHIMS)

从1996年开始，WHI记忆研究（WHIMS）招募了WHI激素试验的参与者，以测试激素治疗是否可以预防认知下降，轻度认知障碍和可能的痴呆症（包括阿尔茨海默病）。在WHI激素试验提前停止后，以前的行业资金被撤回。NHLBI同意提供4年的资金来完成雌激素单独试验;继续监测试验后的认知健康;并进行脑部MRI扫描以阐明血管疾病的作用。 鉴于迄今为止的研究结果，人口痴呆症负担的增加，以及使用经典流行病学方法和新技术研究其原因的必要性，NHLBI在2008年扩展了该项目，以充分利用这一独特的资源。

Beginning in 1996, the WHI Memory Study (WHIMS) enrolled participants from the WHI hormone trials to test whether hormone therapy prevented cognitive decline, mild cognitive impairment, and probable dementia (including Alzheimer's disease). After the WHI hormone trials were stopped early, previous industry funding was withdrawn. NHLBI agreed to 4 years of funding to complete the Estrogen-Alone trial; continue monitoring post-trial cognitive health; and perform brain MRI scans to elucidate the role of vascular disease. Given the findings to date, the increasing population dementia burden, and the need to study its causes using both classic epidemiologic methods and new technologies, NHLBI extended this project in 2008 in order to fully leverage this unique resource.