NAD Metabolism and Signaling Conference

描述（由申请人提供）：在过去几年中，对维生素b3衍生代谢物烟酰胺腺嘌呤二核苷酸（NAD+）的兴趣有了很大的复苏，包括其生物合成的各种途径和其消耗产生的信号分子。在20世纪后期，人们有一种感觉，认为NAD+已经被完全理解，而且数量太多，无法进行监管。这一结论主要源于众所周知的NAD+、NADH、NADP和NADPH作为氢化物转移酶（如氧化还原酶）的辅酶的功能，这些辅酶在中间代谢中起着核心作用。然而，参加2009年FASEB夏季会议的众多研究人员已经证明，NAD+在多种调节途径中被消耗，由意想不到的维生素和中间体合成，并被加工成具有意想不到活性的新型调节代谢物。自这些新发现以来，越来越多的实验室意识到有必要了解NAD+的完整代谢组，如NAD+代谢物和相关的信号分子。今天，NAD+的研究人员来自生物学、生物化学、细胞生物学、生理学和医学的各个领域。同意参加本次会议的研究者大会构成了第一次关于NAD+代谢和信号的FASEB会议。这次会议是第一次提供一个单一的场所，汇集了来自NAD+控制的酶促过程不同领域的具有NAD+思想的研究人员。本次会议将提供NAD+多系统和多尺度功能的基础背景，并提供营养学、酶学、信号传导、细胞生物学、生理学、糖尿病、免疫学/炎症和衰老等方面的跨学科培训。这次会议应该为青年科学家提供一个很好的培训机会，他们有机会展示他们的工作并了解最新的发展。主题领域将包括NAD+依赖性酶的细胞途径和医学意义，如sirtuins、糖水解酶、氧化还原酶、PARPs、PARGs和adp -核糖基环化酶，以及NAD+合成酶和NAD+激酶。程序性讨论将强调当前知识的整合，以发展NAD+代谢组的系统生物学观点。

DESCRIPTION (provided by applicant): Over the last several years there has been a great resurgence in the interest of the vitamin B3-derived metabolite, nicotinamide adenine dinucleotide (NAD+), including the various pathways to its biosynthesis and the signaling molecules generated from its consumption. There was a sense in the late 20th century that NAD+ was entirely understood and was too abundant to be regulatory. Mainly, this conclusion stemmed from the well-known functions of NAD+, NADH, NADP and NADPH as co-enzymes for hydride transfer enzymes, such as oxidoreductases, which play central roles in intermediary metabolism. However, the numerous investigators assembled for this 2009 summer FASEB meeting have demonstrated that NAD+ is consumed in a wide variety of regulatory pathways, synthesized from unanticipated vitamins and intermediates, and is processed to novel regulatory metabolites with unanticipated activities. Since these new discoveries, more and more laboratories have realized the need to understand the complete metabolome of NAD+, e.g. NAD+ metabolites and related signaling molecules. Today, NAD+ investigators are drawn from all areas of biology, biological chemistry, cell biology, physiology and medicine. The assemblies of investigators who have agreed to participate in this meeting constitute the first FASEB meeting on NAD+ metabolism and signaling. This meeting is the first of its kind to offer a single venue that brings together NAD+-minded researchers from diverse areas of NAD+ controlled enzymatic processes. This meeting will provide fundamental background in multi-systems and multi-scale functions of NAD+, and provide interdisciplinary training in nutrition, enzymology, signaling, cell biology, physiology, diabetes, immunology/inflammation and aging. This conference should provide an excellent training opportunity for young scientists, who have an opportunity to present their work and learn the about the latest developments. Topic areas will include the cellular pathways and medical implications of such NAD+- dependent enzymes as sirtuins, glycohydrolases, oxidoreductases, PARPs, PARGs, and ADP-ribosyl cyclases, as well as NAD+ synthesizing enzymes and NAD+ kinases. Programmatic discussions will emphasize integration of current knowledge to develop a systems biology view of the NAD+ metabolome.