Cell Contact & Adhesion Gordon Research Conference

电池接触

• 批准号: 7609297
• 负责人: PIERRE D MCCREA
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-06 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7609297
• 关键词: Address; Adhesions; Adhesives; Area; Basic Science; Biological Models; Bulla; Cell Line; Cell Polarity; Cell-Cell Adhesion; Cells; Collaborations; Communication; Development; Discipline; Disease; Environment; Fostering; Future; Generations; Genetic Crossing Over; Goals; Hand; Human; Individual; International; Invertebrates; Maintenance; Malignant Neoplasms; Molecular; Neoplasm Metastasis; New Hampshire; Outcome; Pathology; Physiology; Plant Roots; Process; Research; Research Personnel; Resort; Signal Pathway; Site; Sum; System; Tissues; Trust; United States National Institutes of Health; Woman; cancer initiation; grasp; human disease; interest; meetings; microbial; pathogen; public health relevance; skin disorder; symposium

DESCRIPTION (provided by applicant): We request partial support for three (3) international meetings on "Cell Contact & Adhesion", which will be held in 2009 (June 28 - July 3) at the Waterville Valley Resort (New Hampshire USA), and again in 2011 & 2013 - likely alternating between the Waterville Valley and Il Ciocco (Barga IT) sites. The larger goal and significance is to enhance our basic understanding of cell- cell adhesion systems at the molecular level, for example, how the molecules involved form physical adhesive contacts and how they contribute to signaling pathways allowing communication between cells. These concerns are central to obtaining a grasp of both normal development and multiple pathologies where aberrations in contact physiology are contributory. Human disease conditions of direct relevance include the progression of cancer from initiation through metastasis, host-pathogen interactions and blistering skin diseases. Nine (9) sessions are outlined, which together address the most exciting advances or areas of opportunity in a variety of cell-cell adhesion contexts - such as adherens, gap, tight and desmosomal junctions (as well as others). Using cell-line and diverse vertebrate and invertebrate model systems, a particular emphasis for the 2009 conference will be upon the generation and maintenance of cell polarity, as well as the execution of morphogenic processes. Such scientific interests relate intimately with an additional central session that will explicitly address cancer. Our specific aims in 2009 include the assembly 44 gifted speakers/ investigators and 9 session chairs. In conjunction with the Chair and Vice-Chair, such individuals will: provide the latest views and unpublished experimental evidence available in their research areas; facilitate the active discussion and debate of issues at the forefront of the cell-cell adhesion field and its cross-over disciplines; foster an environment where researchers can develop meaningful professional relationships and the trust needed to promote future collaborations; assist the active involvement of women and under-represented groups; encourage the significant participation of individuals from around the globe; and importantly, facilitate the mixing of postdoctoral and graduate trainees with more senior investigators. In sum, over the course of three (3) conferences that will span five years, the NIH support we seek will be instrumental to an important and dynamic field with deep roots in both basic science and the understanding of human disease. Public Health Relevance: The Cell Contact & Adhesion Gordon Research Conference will advance research facilitating better outcomes for humans afflicted by diseases such as cancer, microbial invasion and blistering skin diseases. In these and additional pathologies, contact and communication that would normally take place between neighboring cells becomes altered and leads to the disruption of both cell and tissue functions, for example, as occurs during cancer metastasis. By providing both young and senior investigators an opportunity to share their latest results first-hand while developing trust to facilitate future collaborations, the proposed conference provides a valuable and proven opportunity to spur needed biomedical advances.

描述（由申请人提供）：我们请求为三（3）次关于“细胞接触与粘附”的国际会议提供部分支持，这些会议将于2009年（6月28日至7月3日）在沃特维尔谷度假村（新罕布什尔州美国）举行，并于2011年和2013年再次举行-可能在沃特维尔谷和Il Ciocco（巴尔加IT）地点之间交替举行。更大的目标和意义是在分子水平上增强我们对细胞-细胞粘附系统的基本理解，例如，所涉及的分子如何形成物理粘附接触，以及它们如何有助于允许细胞之间通信的信号通路。这些问题是核心，以获得正常的发展和多种病理接触生理异常的贡献掌握。直接相关的人类疾病状况包括癌症从起始到转移的进展、宿主-病原体相互作用和起泡性皮肤病。 概述了九（9）次会议，共同讨论了各种细胞-细胞粘附背景中最令人兴奋的进展或机会领域-如粘附，间隙，紧密连接和桥粒连接（以及其他）。利用细胞系和不同的脊椎动物和无脊椎动物模型系统，2009年会议的一个特别重点将是细胞极性的产生和维持，以及形态发生过程的执行。这些科学兴趣与一个额外的中心会议密切相关，该会议将明确讨论癌症问题。 我们在2009年的具体目标包括大会44名有才华的发言者/调查员和9名会议主席。与主席和副主席一起，这些人将：提供其研究领域的最新观点和未发表的实验证据;促进对细胞-细胞粘附领域及其交叉学科前沿问题的积极讨论和辩论;营造一种环境，使研究人员能够发展有意义的专业关系和促进未来合作所需的信任;协助妇女和代表性不足的群体积极参与;鼓励来自地球仪各地的个人积极参与;重要的是，促进博士后和研究生学员与更资深的调查人员的混合。总而言之，在为期五年的三（3）次会议期间，我们寻求的NIH支持将有助于一个重要而充满活力的领域，该领域在基础科学和对人类疾病的理解方面都有着深厚的根基。 公共卫生相关性：细胞接触和粘附戈登研究会议将推进研究，促进更好的结果，为人类遭受疾病，如癌症，微生物入侵和起泡皮肤病。在这些和另外的病理中，通常在相邻细胞之间发生的接触和通信被改变，并导致细胞和组织功能的破坏，例如，如在癌症转移期间发生的。通过为年轻和高级研究人员提供第一手分享他们最新成果的机会，同时建立信任以促进未来的合作，拟议的会议提供了一个宝贵的和经过验证的机会，以刺激所需的生物医学进步。