Fourth International Seizure Prediction Workshop

第四届国际癫痫预测研讨会

• 批准号: 7674468
• 负责人: IVAN OSORIO
• 金额: $ 4.5万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7674468
• 关键词: Academia; Affect; Brain; Cessation of life; Child; Childhood; Cities; Clinical; Complex; Earthquakes; Educational workshop; Electroencephalography; Engineering; Ensure; Epilepsy; Europe; Event; Fostering; Frontal Lobe Epilepsy; Group Meetings; Growth; Human; Industry; Injury; International; Kansas; Knowledge; Longevity; Marketing; Mathematics; Meteorology; Methods; Minority; Minority Groups; Mission; Morbidity - disease rate; Neurosurgeon; Patients; Pharmaceutical Preparations; Population; Probability; Quality of life; Rare Diseases; Research; Research Personnel; Resistance; Safety; Scientist; Seizures; Translational Research; Voice; Woman; Work; clinical application; cost; disability; economic value; expectation; experience; improved; meetings; mortality; nervous system disorder; novel; public health relevance; success

DESCRIPTION (provided by applicant): Epilepsy, one of the most prevalent neurological disorders, affects approximately 1% (>60 million) of the world's population. In an estimated 20 million of the patients, seizures are not controlled even by multiple anti-seizure drugs. In-depth analyses of the causes of disability, injury and death in patients with pharmaco-resistant epilepsy finds seizure unpredictability the most crippling, negatively impacting safety, life span and quality of life. In recognition of the high clinical/humanitarian and socio-economic value of accurate seizure prediction and of the need for knowledge sharing to succeed in this task, an international interdisciplinary group composed of epileptologists, engineers, physicists, mathematicians, neurosurgeons and neuroscientists (the International Seizure Prediction Group) has created and greatly benefited from a forum where strategies and methods for predicting seizures are assessed and refined as needed and research directions are laid out. Seizure warning and control have been added to the mission of this group, in recognition of their inherent value. In order to fulfill these worthy and challenging objectives, this group meets every 18 months, alternating between the USA and Europe to assess and disseminate novel contributions and facilitate and increase participation in this unprecedented interdisciplinary project, to increase the probability of success. This application seeks support for the Fourth International Seizure Prediction Workshop (ISWP4) to be held in Kansas City in June 2009. More specifically, it asks for support to cover costs of participation of Session Chairs, Speakers and Young Investigators including women and racial and ethnic minorities, working on seizure dynamics, automated seizure prediction and control. This workshop's format will be highly interactive, promoting discussion of relevant issues and will introduce five new sessions: 1. Nocturnal Frontal lobe epilepsy: A rare disease with great potential for predictability; 2. Seizure prediction in children: The overlooked challenge; 3. Didactic ("Epilepsy for Non-epileptologists" and "Mathematics for Epileptologists") to facilitate and promote meaningful interactions between this technically diverse group of investigators; 4. Academia-Industry to initiate a much needed interaction that will foster translational research with clinical applicability for the benefit of patients; 5. Patients-Researchers-Industry session, to provide a forum for patients to voice ideas and expectations. PUBLIC HEALTH RELEVANCE: The Fourth International Workshop on Seizure Prediction (ISPW4) will be convened in Kansas City, Kansas, June 4-7, 2009. This scientific meeting will be attended by international experts working in the fields of seizure prediction, seizure dynamics and seizure control. Scientists with international recognition in prediction of complex phenomena such as earthquakes and the financial markets will be invited to share their knowledge, experience and challenges. The fields of seizure prediction, seizure dynamics and seizure control offer the promise of improving quality of life and decreasing morbidity and mortality in a cost-effective manner. This application seeks support for the participation in this workshop of: a) Three keynote speakers, one each from the fields of seismology, meteorology and finance with extensive experience in prediction of events in their respective fields; b) Two keynote speakers with expertise in Nocturnal Frontal Lobe Epilepsy, a rare disease with onset in childhood; c) Two keynote speakers, one with expertise in Ontogeny of Human EEG and the other on the challenges for quantitative analysis of EEG in the developing brain; and d) Forty-three invited investigators, speakers/session-chairs, approximately 60% comprising senior level academic researchers and the remaining 40% selected to target junior investigators, women and minorities in order to ensure appropriate representation.

描述（由申请人提供）：癫痫是最常见的神经系统疾病之一，影响世界人口的约1%（> 6000万）。估计有2000万患者的癫痫发作即使使用多种抗癫痫药物也无法控制。对耐药性癫痫患者残疾、损伤和死亡原因的深入分析发现，癫痫发作的不可预测性是最严重的，对安全性、寿命和生活质量产生负面影响。认识到准确的癫痫发作预测具有很高的临床/人道主义和社会经济价值，以及需要分享知识以成功完成这项任务，一个由癫痫学家、工程师、物理学家、数学家组成的国际跨学科小组，神经外科医生和神经科学家（International Seizure Prediction Group）创建了一个论坛，并从中受益匪浅，在该论坛上评估并根据需要完善预测缉获量的战略和方法，并确定研究方向。由于认识到其内在价值，已将癫痫警报和控制添加到该小组的使命中。为了实现这些有价值和具有挑战性的目标，该小组每18个月举行一次会议，在美国和欧洲之间交替，以评估和传播新的贡献，促进和增加对这个前所未有的跨学科项目的参与，以增加成功的可能性。本申请寻求对将于2009年6月在堪萨斯城举行的第四次国际癫痫发作预测讲习班（ISWP 4）的支持。更具体地说，它要求提供支持，以支付会议主席、发言人和青年调查员（包括妇女和少数民族）参与缉获动态、自动缉获预测和控制工作的费用。这次研讨会的形式将是高度互动的，促进有关问题的讨论，并将推出五个新的会议：1。夜间额叶癫痫：一种罕见的疾病，具有很大的可预测性; 2。儿童癫痫发作预测：被忽视的挑战; 3。教学（“癫痫非癫痫学家”和“数学癫痫学家”），以促进和促进这一技术上多样化的研究者群体之间有意义的互动; 4。学术界和工业界开展急需的互动，促进具有临床适用性的转化研究，造福患者; 5.患者-研究人员-行业会议，为患者提供一个表达想法和期望的论坛。公共卫生相关性：第四届癫痫发作预测国际研讨会（ISPW 4）将于2009年6月4日至7日在堪萨斯州的堪萨斯城召开。在缉获预测、缉获动态和缉获控制领域工作的国际专家将出席这次科学会议。在预测地震和金融市场等复杂现象方面具有国际知名度的科学家将被邀请分享他们的知识，经验和挑战。癫痫发作预测、癫痫发作动力学和癫痫发作控制领域提供了以具有成本效益的方式改善生活质量和降低发病率和死亡率的希望。这项申请寻求对下列人员参加这一讲习班的支助：（a）三名主旨发言人，分别来自地震学、气象学和金融学领域，在预测各自领域的事件方面具有丰富经验;（B）两名主旨发言人，具有夜间额叶癫痫这一儿童期发病的罕见疾病的专门知识; c）两名主旨发言人，一名具有人类EEG个体发生学的专业知识，另一名关于发育中大脑EEG定量分析的挑战;和d）43名受邀研究员、演讲者/会议主席，其中约60%由高级学术研究人员组成，其余40%被选为初级研究人员，妇女和少数民族，以确保适当的代表性。

项目成果

Controversies in epilepsy: debates held during the Fourth International Workshop on Seizure Prediction.

• DOI: 10.1016/j.yebeh.2010.06.009
• 发表时间: 2010-09
• 期刊: Epilepsy & behavior : E&B
• 作者: Frei MG;Zaveri HP;Arthurs S;Bergey GK;Jouny CC;Lehnertz K;Gotman J;Osorio I;Netoff TI;Freeman WJ;Jefferys J;Worrell G;Quyen Mle V;Schiff SJ;Mormann F
• 通讯作者: Mormann F