2009 Stress Proteins in Growth, Development, and Disease Gordon Research Conferen

描述（由申请人提供）：生物体承受压力的能力对于生存至关重要，并且人们越来越认识到细胞压力反应在生长和发育过程中至关重要。事实上，越来越多的人类疾病，尤其是那些影响神经元的疾病，都是由应激反应途径的缺陷或应激蛋白无法保护细胞引起的。压力反应途径也与衰老、感染、癌症和代谢疾病有关。因此，生物医学研究人员为调节应激反应做出了重大努力，这并不奇怪。因此，提供一个论坛来聚集那些寻求将人类疾病的潜在机制与应激基因的调节和应激蛋白功能联系起来的科学家是至关重要的。这一独特集会的主要论坛之一是“生长、发育和疾病中的应激蛋白”戈登研究会议 (GRC)。下一次会议是该系列的第五次会议，将于 2009 年 6 月 28 日至 7 月 3 日在新罕布什尔州安多弗的 Proctor 学院举行。本次会议的主席是 Jeffrey Brodsky（匹兹堡大学，匹兹堡，宾夕法尼亚州），副主席是 Lea Sistonen（Abo Akademi 大学，芬兰图尔库）。普罗克特学院在支持 GRC 方面有着悠久的历史，并且设有残疾人通道。迄今为止，已有 26 名国际知名演讲者承诺出席 2009 年会议并在会上发言，其中包括 10 名女性和一名非裔美国人。尽管如此，我们仍将做出重大努力，以增加与会者的多样性，吸引更多科学家进入应激蛋白领域，并促进新合作的形成。为此，我们已准备好时间表，将从提交海报展示的摘要中选出 10 个发言席位，并将优先考虑年轻科学家和代表性不足群体的科学家。会议日程也将准备好，以确保不同模型系统得到平等的代表。此外，会议出席人数将“上限”为150人，以促进有效的互动和讨论。总体而言，我们寻求加强应激蛋白领域前沿进展的传播和新合作的形成。反过来，这将带来进步并拓宽我们对应激蛋白在人类健康、衰老和疾病中的作用的理解。细胞，尤其是神经元，生活在恶劣的条件下。有时细胞会缺乏营养，有时细胞需要快速生长，有时细胞会暴露于有毒物质。细胞还可能表达畸形蛋白质，如阿尔茨海默病、亨廷顿病和帕金森病中所发生的那样。然而，为了抵消压力带来的危险后果（压力不仅会导致疾病，还会导致衰老），细胞会产生特定的蛋白质来保护自己。 2009 年戈登研究会议题为“生长、发育和疾病中的应激蛋白”，汇集了研究压力与人类疾病之间联系的科学家，并为该领域的研究人员提供了一个独特的论坛，以汇集和确定预防压力相关疾病的新途径。 公共卫生相关性：细胞，尤其是神经元，生活在恶劣的条件下。有时细胞会缺乏营养，有时细胞需要快速生长，有时细胞会暴露于有毒物质。细胞还可能表达畸形蛋白质，如阿尔茨海默病、亨廷顿病和帕金森病中所发生的那样。然而，为了抵消压力带来的危险后果（压力不仅会导致疾病，还会导致衰老），细胞会产生特定的蛋白质来保护自己。 2009 年戈登研究会议题为“生长、发育和疾病中的应激蛋白”，汇集了研究压力与人类疾病之间联系的科学家，并为该领域的研究人员提供了一个独特的论坛，以汇集和确定预防压力相关疾病的新途径。

DESCRIPTION (provided by applicant): The ability of organisms to withstand stress is critical for survival, and there is a growing appreciation that cellular stress responses are vital during growth and development. In fact, an increasing number of human diseases-particularly those affecting neurons-arise from defects in stress response pathways or from the inability of stress proteins to protect cells. Stress response pathways have also been linked to ageing, infection, cancer, and metabolic diseases. Not surprisingly, then, significant efforts to modulate the stress response have been taken by biomedical researchers. Therefore, it is critical that a forum is provided to assemble scientists who seek to connect the mechanisms underlying human diseases with the regulation of stress genes and with stress protein function. One of the premier forums for this unique assembly is the "Stress Proteins in Growth, Development and Disease" Gordon Research Conference (GRC). The next conference, which is the fifth in this series, will be held from June 28th - July 3rd, 2009, at the Proctor Academy in Andover, NH. The Chair for this meeting is Jeffrey Brodsky (University of Pittsburgh, Pittsburgh, PA) and the Vice-Chair is Lea Sistonen (Abo Akademi University, Turku, Finland). The Proctor Academy has a long history in supporting GRCs and is handicapped accessible. Thus far, 26 internationally recognized speakers have committed to attending and speaking at the 2009 meeting, including 10 women and one African-American. Nevertheless, significant efforts will be undertaken to increase the diversity of meeting attendees, to bring more scientists into the stress protein field, and to catalyze the formation of new collaborations. To this end, the schedule has been prepared so that 10 speaking slots will be chosen from abstracts submitted for poster presentations, and preference will be given to younger scientists and to those from under-represented groups. The meeting schedule will also be prepared to ensure that different model systems are equally represented. In addition, meeting attendance will be "capped" at 150 to facilitate effective interactions and discussions. Overall, we seek to enhance the dissemination of cutting-edge advances and the formation of new collaborations in the stress protein field. This, in turn, will lead to advances and broaden our understanding of the roles of stress proteins in human health, aging, and disease. Cells-especially neurons-live under harsh conditions. There are times when cells are starved for nutrients, times when cells need to exhibit rapid growth, and times when cells are exposed to toxic agents. Cells may also express misshapen proteins, as occurs in Alzheimer's, Huntington's, and Parkinson's disease. However, to off-set the dangerous consequences of stress, which can lead not only to disease but also to ageing, cells produce specific proteins to protect themselves. The 2009 Gordon Research Conference, entitled "Stress Proteins in Growth, Development, and Disease", brings together scientists who study the link between stress and human disease, and provides a unique forum for researchers in this field to assemble and identify new avenues to prevent stress-related diseases. PUBLIC HEALTH RELEVANCE: Cells-especially neurons-live under harsh conditions. There are times when cells are starved for nutrients, times when cells need to exhibit rapid growth, and times when cells are exposed to toxic agents. Cells may also express misshapen proteins, as occurs in Alzheimer's, Huntington's, and Parkinson's disease. However, to off-set the dangerous consequences of stress, which can lead not only to disease but also to ageing, cells produce specific proteins to protect themselves. The 2009 Gordon Research Conference, entitled "Stress Proteins in Growth, Development, and Disease", brings together scientists who study the link between stress and human disease, and provides a unique forum for researchers in this field to assemble and identify new avenues to prevent stress-related diseases.