2009 Stress Proteins in Growth, Development, and Disease Gordon Research Conferen

描述(申请人提供)：生物体承受压力的能力对生存至关重要，越来越多的人认识到细胞应激反应在生长和发育过程中至关重要。事实上，越来越多的人类疾病--特别是那些影响神经元的疾病--是由于应激反应途径的缺陷或应激蛋白无法保护细胞而引起的。压力反应途径也与衰老、感染、癌症和代谢性疾病有关。因此，毫不奇怪，生物医学研究人员已经做出了重大努力来调节压力反应。因此，至关重要的是，提供一个论坛，让寻求将人类疾病的潜在机制与应激基因的调节和应激蛋白功能联系起来的科学家聚集在一起。这一独特会议的主要论坛之一是“生长、发育和疾病中的应激蛋白”戈登研究会议(GRC)。下一次会议是本系列的第五次，将于2009年6月28日至7月3日在密歇根州安多弗的普罗科特学院举行。本次会议的主席是Jeffrey Brodsky(匹兹堡大学，宾夕法尼亚州匹兹堡)，副主席是Lea Sistonen(阿博·阿卡德米大学，芬兰图尔库)。普罗科特学院在支持GRC方面有很长的历史，而且残疾人可以进入。迄今为止，已有26名国际公认的发言者承诺出席2009年会议并发言，其中包括10名妇女和1名非洲裔美国人。然而，将作出重大努力，以增加与会者的多样性，使更多的科学家进入应激蛋白领域，并催化形成新的合作。为此，编制了时间表，以便从提交海报介绍的摘要中选择10个发言时段，并优先考虑年轻科学家和代表性不足群体的科学家。还将编制会议时间表，以确保不同模型系统的代表人数相等。此外，会议出席人数上限将为150人，以促进有效的互动和讨论。总体而言，我们寻求加强应激蛋白领域前沿进展的传播和新合作的形成。这反过来将带来进步，并拓宽我们对应激蛋白在人类健康、衰老和疾病中的作用的理解。细胞--尤其是神经元--生活在恶劣的条件下。有时细胞缺乏营养，有时细胞需要快速生长，有时细胞暴露在有毒物质中。细胞也可能表达畸形蛋白，就像阿尔茨海默氏症、亨廷顿氏症和帕金森氏症一样。然而，为了抵消压力的危险后果，压力不仅会导致疾病，还会导致衰老，细胞会产生特定的蛋白质来保护自己。2009年戈登研究会议题为《生长、发育和疾病中的应激蛋白》，汇集了研究压力和人类疾病之间联系的科学家，并为该领域的研究人员提供了一个独特的论坛，以聚集和确定预防应激相关疾病的新途径。 与公共健康相关：细胞--尤其是神经元--生活在恶劣的条件下。有时细胞缺乏营养，有时细胞需要快速生长，有时细胞暴露在有毒物质中。细胞也可能表达畸形蛋白，就像阿尔茨海默氏症、亨廷顿氏症和帕金森氏症一样。然而，为了抵消压力的危险后果，压力不仅会导致疾病，还会导致衰老，细胞会产生特定的蛋白质来保护自己。2009年戈登研究会议题为《生长、发育和疾病中的应激蛋白》，汇集了研究压力和人类疾病之间联系的科学家，并为该领域的研究人员提供了一个独特的论坛，以聚集和确定预防应激相关疾病的新途径。

DESCRIPTION (provided by applicant): The ability of organisms to withstand stress is critical for survival, and there is a growing appreciation that cellular stress responses are vital during growth and development. In fact, an increasing number of human diseases-particularly those affecting neurons-arise from defects in stress response pathways or from the inability of stress proteins to protect cells. Stress response pathways have also been linked to ageing, infection, cancer, and metabolic diseases. Not surprisingly, then, significant efforts to modulate the stress response have been taken by biomedical researchers. Therefore, it is critical that a forum is provided to assemble scientists who seek to connect the mechanisms underlying human diseases with the regulation of stress genes and with stress protein function. One of the premier forums for this unique assembly is the "Stress Proteins in Growth, Development and Disease" Gordon Research Conference (GRC). The next conference, which is the fifth in this series, will be held from June 28th - July 3rd, 2009, at the Proctor Academy in Andover, NH. The Chair for this meeting is Jeffrey Brodsky (University of Pittsburgh, Pittsburgh, PA) and the Vice-Chair is Lea Sistonen (Abo Akademi University, Turku, Finland). The Proctor Academy has a long history in supporting GRCs and is handicapped accessible. Thus far, 26 internationally recognized speakers have committed to attending and speaking at the 2009 meeting, including 10 women and one African-American. Nevertheless, significant efforts will be undertaken to increase the diversity of meeting attendees, to bring more scientists into the stress protein field, and to catalyze the formation of new collaborations. To this end, the schedule has been prepared so that 10 speaking slots will be chosen from abstracts submitted for poster presentations, and preference will be given to younger scientists and to those from under-represented groups. The meeting schedule will also be prepared to ensure that different model systems are equally represented. In addition, meeting attendance will be "capped" at 150 to facilitate effective interactions and discussions. Overall, we seek to enhance the dissemination of cutting-edge advances and the formation of new collaborations in the stress protein field. This, in turn, will lead to advances and broaden our understanding of the roles of stress proteins in human health, aging, and disease. Cells-especially neurons-live under harsh conditions. There are times when cells are starved for nutrients, times when cells need to exhibit rapid growth, and times when cells are exposed to toxic agents. Cells may also express misshapen proteins, as occurs in Alzheimer's, Huntington's, and Parkinson's disease. However, to off-set the dangerous consequences of stress, which can lead not only to disease but also to ageing, cells produce specific proteins to protect themselves. The 2009 Gordon Research Conference, entitled "Stress Proteins in Growth, Development, and Disease", brings together scientists who study the link between stress and human disease, and provides a unique forum for researchers in this field to assemble and identify new avenues to prevent stress-related diseases. PUBLIC HEALTH RELEVANCE: Cells-especially neurons-live under harsh conditions. There are times when cells are starved for nutrients, times when cells need to exhibit rapid growth, and times when cells are exposed to toxic agents. Cells may also express misshapen proteins, as occurs in Alzheimer's, Huntington's, and Parkinson's disease. However, to off-set the dangerous consequences of stress, which can lead not only to disease but also to ageing, cells produce specific proteins to protect themselves. The 2009 Gordon Research Conference, entitled "Stress Proteins in Growth, Development, and Disease", brings together scientists who study the link between stress and human disease, and provides a unique forum for researchers in this field to assemble and identify new avenues to prevent stress-related diseases.