2009 Stress Proteins in Growth, Development, and Disease Gordon Research Conferen

描述（由申请人提供）：生物体承受压力的能力对生存至关重要，并且越来越多的人认识到细胞应激反应在生长和发育过程中至关重要。事实上，越来越多的人类疾病——尤其是那些影响神经元的疾病——是由于应激反应途径的缺陷或应激蛋白无法保护细胞而引起的。应激反应途径也与衰老、感染、癌症和代谢疾病有关。因此，毫不奇怪，生物医学研究人员已经做出了重大努力来调节压力反应。因此，至关重要的是，提供一个论坛，聚集那些寻求将人类疾病的潜在机制与应激基因的调节和应激蛋白功能联系起来的科学家。这个独特集会的主要论坛之一是“生长，发育和疾病中的应激蛋白”戈登研究会议（GRC）。下一次会议是本系列的第五次会议，将于2009年6月28日至7月3日在新罕布什尔州安多弗的普罗科特学院举行。本次会议的主席是Jeffrey Brodsky（宾夕法尼亚州匹兹堡市匹兹堡大学），副主席是Lea Sistonen（芬兰图尔库阿博学术大学）。Proctor学院在支持GRCs方面有着悠久的历史，并且是残疾人无障碍的。到目前为止，已有26位国际公认的演讲者承诺出席2009年的会议并发表演讲，其中包括10名妇女和1名非洲裔美国人。尽管如此，将作出重大努力来增加与会者的多样性，使更多的科学家进入应激蛋白领域，并促进新的合作的形成。为此，我们制定了时间表，从提交的用于海报展示的摘要中选择10个发言机会，并优先考虑年轻的科学家和来自代表性不足群体的科学家。会议时间表也将编制，以确保不同的模式系统有平等的代表。此外，会议出席人数将“上限”为150人，以促进有效的互动和讨论。总的来说，我们寻求加强在应激蛋白领域的前沿进展的传播和形成新的合作。反过来，这将导致进步，并扩大我们对应激蛋白在人类健康、衰老和疾病中的作用的理解。细胞——尤其是神经元——生活在恶劣的环境中。有时细胞缺乏营养，有时细胞需要快速生长，有时细胞暴露在有毒物质中。细胞也可能表达畸形蛋白，如阿尔茨海默氏症、亨廷顿氏症和帕金森氏症。然而，为了抵消压力带来的危险后果（压力不仅会导致疾病，还会导致衰老），细胞会产生特定的蛋白质来保护自己。2009年戈登研究会议题为“生长、发育和疾病中的应激蛋白”，汇集了研究应激与人类疾病之间联系的科学家，并为该领域的研究人员提供了一个独特的论坛，以聚集和确定预防应激相关疾病的新途径。

DESCRIPTION (provided by applicant): The ability of organisms to withstand stress is critical for survival, and there is a growing appreciation that cellular stress responses are vital during growth and development. In fact, an increasing number of human diseases-particularly those affecting neurons-arise from defects in stress response pathways or from the inability of stress proteins to protect cells. Stress response pathways have also been linked to ageing, infection, cancer, and metabolic diseases. Not surprisingly, then, significant efforts to modulate the stress response have been taken by biomedical researchers. Therefore, it is critical that a forum is provided to assemble scientists who seek to connect the mechanisms underlying human diseases with the regulation of stress genes and with stress protein function. One of the premier forums for this unique assembly is the "Stress Proteins in Growth, Development and Disease" Gordon Research Conference (GRC). The next conference, which is the fifth in this series, will be held from June 28th - July 3rd, 2009, at the Proctor Academy in Andover, NH. The Chair for this meeting is Jeffrey Brodsky (University of Pittsburgh, Pittsburgh, PA) and the Vice-Chair is Lea Sistonen (Abo Akademi University, Turku, Finland). The Proctor Academy has a long history in supporting GRCs and is handicapped accessible. Thus far, 26 internationally recognized speakers have committed to attending and speaking at the 2009 meeting, including 10 women and one African-American. Nevertheless, significant efforts will be undertaken to increase the diversity of meeting attendees, to bring more scientists into the stress protein field, and to catalyze the formation of new collaborations. To this end, the schedule has been prepared so that 10 speaking slots will be chosen from abstracts submitted for poster presentations, and preference will be given to younger scientists and to those from under-represented groups. The meeting schedule will also be prepared to ensure that different model systems are equally represented. In addition, meeting attendance will be "capped" at 150 to facilitate effective interactions and discussions. Overall, we seek to enhance the dissemination of cutting-edge advances and the formation of new collaborations in the stress protein field. This, in turn, will lead to advances and broaden our understanding of the roles of stress proteins in human health, aging, and disease. Cells-especially neurons-live under harsh conditions. There are times when cells are starved for nutrients, times when cells need to exhibit rapid growth, and times when cells are exposed to toxic agents. Cells may also express misshapen proteins, as occurs in Alzheimer's, Huntington's, and Parkinson's disease. However, to off-set the dangerous consequences of stress, which can lead not only to disease but also to ageing, cells produce specific proteins to protect themselves. The 2009 Gordon Research Conference, entitled "Stress Proteins in Growth, Development, and Disease", brings together scientists who study the link between stress and human disease, and provides a unique forum for researchers in this field to assemble and identify new avenues to prevent stress-related diseases. PUBLIC HEALTH RELEVANCE: Cells-especially neurons-live under harsh conditions. There are times when cells are starved for nutrients, times when cells need to exhibit rapid growth, and times when cells are exposed to toxic agents. Cells may also express misshapen proteins, as occurs in Alzheimer's, Huntington's, and Parkinson's disease. However, to off-set the dangerous consequences of stress, which can lead not only to disease but also to ageing, cells produce specific proteins to protect themselves. The 2009 Gordon Research Conference, entitled "Stress Proteins in Growth, Development, and Disease", brings together scientists who study the link between stress and human disease, and provides a unique forum for researchers in this field to assemble and identify new avenues to prevent stress-related diseases.