FASEB SRC on Protein Folding in the Cell

FASEB SRC 关于细胞中蛋白质折叠的研究

• 批准号: 8720195
• 负责人: JEFFREY L. BRODSKY
• 金额: $ 0.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-14 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8720195
• 关键词: Academy; Age; Alzheimer' s Disease; Applications Grants; Arts; Biochemical; Biology; Biophysics; Biotechnology; Cataract; Cells; Chemistry; Collaborations; Complex; Computational Biology; Computer Simulation; Cystic Fibrosis; Cytoplasmic Organelle; Defect; Degradation Pathway; Development; Diabetes Mellitus; Discipline; Disease; Drug Industry; Ensure; Environment; Equilibrium; Evolution; Faculty; Family; Family member; Fellowship; Funding; Gap Junctions; Genomics; Goals; Health; Housing; Huntington Disease; Individual; Industry; Interdisciplinary Study; Lead; Link; Liver diseases; Location; Malignant Neoplasms; Molecular Chaperones; Molecular Conformation; Parkinson Disease; Participant; Pathway interactions; Pharmacology; Physics; Play; Positioning Attribute; Postdoctoral Fellow; Price; Private Sector; Process; Protein Conformation; Proteins; Recording of previous events; Request for Applications; Research; Research Personnel; Research Proposals; Resources; Rivers; Role; Running; Science; Scientist; Shapes; Students; Sum; System; Techniques; Technology; Training; Underrepresented Minority; United States National Institutes of Health; Universities; Vermont; Woman; Work; Writing; abstracting; aggregation pathway; biological adaptation to stress; career; career development; college; cost; human disease; in vivo; interest; meetings; member; multidisciplinary; next generation; novel strategies; posters; programs; protein aggregation; protein degradation; protein folding; protein misfolding; public health relevance; response; scientific organization; small molecule; symposium; synthetic biology; therapeutic development; tool

DESCRIPTION (provided by applicant): We request partial support for the 2014, 2016 and 2018 FASEB Science Conference on "Protein Folding in the Cell". The 2014 meeting will be held July 20-27, 2014 in Saxton"s River, VT. This extraordinarily successful meeting is unique in bringing together cell biologists, geneticists, biophysicists, biochemists, and mathematical modelers to tackle the complex problems of protein folding and misfolding and their implications for human disease. The extent to which this meeting is central to the development of the field cannot be overstated. Recent progress in this topic has been explosive, as has the number of diseases linked to defects in protein folding and assembly. Thus, a common thread that runs through the conference are the associations between the biophysical consequences of protein folding/misfolding and human disease. Meeting attendees rely on diverse and emerging techniques, including those drawn from genomics, computational biology, biophysics, synthetic biology, and chemistry, and hence presentations highlighting new technological advances will be emphasized. Building upon the successful format that has shaped past meetings, specific sessions will highlight the protein folding pathway, the mechanism of action of molecular chaperones, pathways that lead to protein aggregation, protein folding networks and the evolution of networks, protein degradation pathways, organelle and cytoplasmic stress responses, and the consequences of defects in protein folding on organismal health, ageing, and development. For 2014, specific emphasis will be placed on emerging strategies to pharmacologically "correct" protein misfolding. This meeting also features three integral mid-day poster sessions, which serve as a nexus for more detailed scientific discussions and will facilitate interactions amongst established investigators, students and other early- career scientists and industry representatives. Career development opportunities include lunchtime "topic tables", led by invited speakers and that focus on a single topic relevant to career advancement (Writing Fellowship Proposals, Research in Industry, Faculty Positions at Liberal Arts Colleges, and Balancing Work and Family). This meeting has a strong commitment to increasing the diversity of the scientific workforce, and this is reflected in the diversity of the invited speakers. In addition, one-third of all speakers will be selected from submitted abstracts in order to maximize participant and topical diversity. The small-town environment surrounding Vermont Academy in Saxton"s River VT provides ready access to resources to reduce barriers to participation by attendees accompanied by family members, including moderately priced B&Bs and childcare options. Programs for the 2016 and 2018 conferences will build upon the established strengths and unique niche of the meeting to draw together diverse scientists and research approaches, and highlight new and emerging developments in the field.

描述（由申请人提供）：我们请求部分支持2014年，2016年和2018年FASEB科学会议“细胞中的蛋白质折叠”。2014年会议将于2014年7月20日至27日在佛蒙特州萨克斯顿河举行。这次非常成功的会议是独一无二的，它汇集了细胞生物学家，遗传学家，生物化学家，生物化学家和数学建模师，以解决蛋白质折叠和错误折叠的复杂问题及其对人类疾病的影响。本次会议对于该领域的发展至关重要，这一点怎么强调都不为过。最近在这一主题上的进展是爆炸性的，因为与蛋白质折叠和组装缺陷有关的疾病数量也是爆炸性的。因此，贯穿会议的一条共同主线是蛋白质折叠/错误折叠的生物物理后果与人类疾病之间的关联。与会者依赖于各种新兴技术，包括来自基因组学，计算生物学，生物物理学，合成生物学和化学的技术，因此将强调强调新技术进步的演讲。建立在成功的格式，塑造了过去的会议，具体会议将突出蛋白质折叠途径，分子伴侣的作用机制，导致蛋白质聚集的途径，蛋白质折叠网络和网络的演变，蛋白质降解途径，细胞器和细胞质应激反应，以及蛋白质折叠缺陷对生物体健康，衰老和发育的后果。2014年，将特别强调新出现的“纠正”蛋白质错误折叠的战略。本次会议还包括三个完整的午间海报会议，作为更详细的科学讨论的纽带，并将促进既定研究人员，学生和其他早期职业科学家和行业代表之间的互动。职业发展机会包括午餐时间的“主题表”，由特邀演讲者领导，专注于与职业发展相关的单一主题（撰写奖学金提案，行业研究，文科学院的教师职位以及平衡工作和家庭）。这次会议坚定地致力于增加科学工作者的多样性，这反映在科学工作者的多样性上。 特邀演讲人此外，将从提交的摘要中选出三分之一的发言者，以最大限度地扩大与会者和专题的多样性。佛蒙特州萨克斯顿河学院周围的小城镇环境提供了现成的资源，以减少由家庭成员陪同的与会者参与的障碍，包括价格适中的B& B和儿童保育选择。2016年和2018年会议的计划将建立在会议的既有优势和独特优势的基础上，汇集不同的科学家和研究方法，并突出该领域的新的和新兴的发展。