2009 Antigen Cross Presentation Gordon-sponsored Meeting

2009 年戈登赞助的抗原交叉展示会议

• 批准号: 7671922
• 负责人: Stephen Philip Schoenberger
• 金额: $ 0.7万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-10 至 2010-03-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7671922
• 关键词: Address; Antigen Presentation Pathway; Antigen-Presenting Cells; Antigens; Area; Autoimmunity; Bacteria; Bacterial Infections; Basic Science; Biophysics; CD8B1 gene; Cell Death; Cell surface; Cells; Cellular biology; Chronic; Clinical; Clonal Expansion; Communities; Complex; Cross Presentation; Cross-Priming; Cytotoxic T-Lymphocytes; Dendritic Cells; Development; Discipline; Disease; Effector Cell; Environment; Generations; Genes; Goals; Health; Immune response; Immune system; Immunity; Immunobiology; Immunology; Immunotherapy; International; Investigation; Italy; Lipids; Lymphoid; MHC Class I Genes; MHC antigen; Maintenance; Malignant Neoplasms; Membrane; Molecular; Molecular and Cellular Biology; Organ; Participant; Pathogenesis; Pathway interactions; Peptide/MHC Complex; Peptides; Phagocytes; Phagocytosis; Process; Proteins; Regulation; Research; Research Personnel; Role; Series; Signal Transduction; T-Lymphocyte; Tissue Grafts; Translational Research; Tumor Tissue; Vaccination; Viral; Virus; Virus Diseases; base; cancer immunotherapy; cell killing; cytotoxic; forging; meetings; neuronal cell body; novel strategies; pathogen; programs; protein folding; response; symposium; tumor; tumor immunology; uptake; vaccination strategy

DESCRIPTION (provided by applicant): This proposal seeks partial support for an international conference on Antigen Cross-presentation as part f the Gordon Research Conference series to be held in Il Ciocco, Italy from June 14-19, 2009.The broad and long-term goal to develop and promote this conference emerged from the recognition that this ubiquitous pathway of antigen uptake, transport, and presentation represented a major research area for investigators from several distinct research perspectives, each of which would be served by having a venue in which they could come together to exchange ideas and move this important field forward in the very best traditions of the Gordon Research Conferences. The subject of antigen cross presentation presents an area of investigation that cuts across several scientific fields, including: Cell Biology; Cell Death; Dendritic Cell Immunobiology; Protein Folding; Lipid Biophysics; Signal Transduction; Antigen Processing and Presentation; and Translational Research including Tumor Immunology, Autoimmunity and Host/Pathogen Interactions. We recognize the need for increased interaction across these fields and see this meeting as an opportunity to build a community and forge new collaborative efforts. Background: Cytotoxic T lymphocytes (CTLs) represent a critical component of the adaptive immune response against viruses, intracellular bacteria, and tumors through their ability to kill cells based on the proteins expressed in a target cell. To perform this task, naive CTLs must first be activated within secondary lymphoid organs by an antigen presenting cell (APC) expressing MHC class I/peptide complexes on its cell surface, causing it to undergo clonal expansion and functional differentiation. The resulting effector cells migrate to the periphery where they subsequently recognize the same peptide/MHC complexes on target cell and deliver the cytotoxic 'lethal hit'. In general, the peptides recognized on both APC and target cells are derived from antigens endogenously expressed within target cells. A long-standing paradox in immunology concerned how a professional phagocyte can prime responses against proteins expressed within a target cell. In the case of viral or bacterial infection, one might presume that the APC itself is directly infected with the same pathogen and thus can express the same genes as the infected target cell. In contrast, studies have shown that such responses are primed by uninfected APC, implying that the antigens in question must be taken up by the APC through phagocytosis, and the derived peptides somehow channeled into its own MHC class I presentation pathway, in essence crossing three membranes in the process. The same process guides the generation of effector CTL against tumors and tissue grafts, and has been referred to as 'cross-priming' while the uptake and processing of exogenous antigen for MHC I presentation by professional APC as 'cross-presentation.' The basic science aspects of how this pathway is regulated and the impact of these discoveries on disease pathogenesis and therapy is the focus of this GRC-sponsored meeting. Aims: The specific aims of this meeting are to convene 37 speakers that represent critical areas of antigen cross presentation research with a total of 135 participants for a five-day conference in a relatively isolated setting. The program will feature a keynote address and eight sessions that will broadly address current issues in the cellular and molecular biology of antigen cross presentation, the instructive role of the innate immune system in modulating the context of antigen uptake and presentation, the responsive role of the adaptive immune system in cross-tolerance versus cross-priming, and importantly, the clinical perspectives on this process. The significance of this application is that the GRC-sponsored meeting on Antigen Cross presentation is a unique The health relatedness of this application is that as the cross presentation pathway has been shown to underlie the induction and maintenance of both CD8+ T cell immunity and tolerance to the overwhelming majority of cell-associated antigens, a deeper understanding of its specific mechanisms will allow for new approaches to the immunotherapy of cancer, chronic viral diseases, and cancer, and will aid in the development of superior vaccination strategies.

描述（由申请人提供）：该提案寻求对国际抗原交叉表现会议的部分支持，作为戈登研究会议系列的一部分，将于2009年6月14日至19日在意大利IL Ciocco举行。每个人都可以通过一个场所来融合思想，并在戈登研究会议的最佳传统中向前发展这一重要领域。抗原交叉表现的主题提出了一个研究领域，该领域削减了几个科学领域，包括：细胞生物学；细胞死亡；树突状细胞免疫生物学；蛋白质折叠；脂质生物物理学；信号转导；抗原加工和表现；以及转化研究，包括肿瘤免疫学，自身免疫性和宿主/病原体相互作用。我们认识到有必要增加这些领域的互动，并将这次会议视为建立社区并努力做出新的合作努力的机会。 背景：细胞毒性T淋巴细胞（CTL）代表了针对病毒，细胞内细菌和肿瘤的适应性免疫反应的关键成分，其通过基于在靶细胞中表达的蛋白质杀死细胞的能力。为了执行此任务，必须首先通过抗原呈递细胞（APC）在其细胞表面上表达MHC I/肽配合物的抗原呈现细胞（APC）在次级淋巴机构中激活幼稚的CTL，从而导致其经历克隆扩张和功能分化。所得的效应细胞迁移到周围，随后它们在靶细胞上识别相同的肽/MHC复合物并传递细胞毒性“致命命中”。通常，在APC和靶细胞上识别的肽均来自靶细胞内表达的抗原。一种长期存在的免疫学悖论涉及专业的吞噬细胞如何对靶细胞中表达的蛋白质产生反应。在病毒或细菌感染的情况下，可以假定APC本身直接感染了相同的病原体，因此可以表达与感染靶细胞相同的基因。相比之下，研究表明，这种反应是由未感染的APC启动的，这意味着APC必须通过吞噬作用来吸收所讨论的抗原，并且在此过程中，本质上跨越了三个膜的MHC I类呈现途径，衍生的肽以某种方式引入了其自己的MHC I类呈现途径。相同的过程指导效应子CTL对肿瘤和组织移植物的产生，并被称为“交叉宣传”，而专业APC的MHC I表示和处理外源性抗原的摄取和处理和处理外源性抗原是“交叉​​出现”。该途径如何受到调节的基础科学方面以及这些发现对疾病发病机理和治疗的影响是该GRC赞助的会议的重点。 目的：这次会议的具体目的是召集37位演讲者，代表抗原交叉介绍研究的关键领域，共有135名参与者在相对孤立的环境中进行为期五天的会议。该计划将设有一个主题演讲和八个会议，该课程将在抗原交叉呈现的细胞和分子生物学中广泛解决当前问题，这是先天免疫系统在调节抗原吸收和呈现的背景下的启发性作用，即在交叉跨跨跨跨性别范围内的适应性免疫系统的响应性作用，以及临床上的classical Persive，以及临床上的climical Persiffeixs。该应用的重要性在于，在抗原交叉呈现上的GRC赞助会议是独特的，该应用的健康相关性是，随着交叉呈现途径的诱导和维持CD8+ T细胞免疫和耐受性的诱导和维持是基于对细胞相关抗原的绝大部分理解，因此，对癌症的特定机制的理解将允许癌症的深层理解，因此，对癌症的理解将允许癌症的新方法，因此疾病和癌症，将有助于制定优质的疫苗接种策略。