2009 Antigen Cross Presentation Gordon-sponsored Meeting
2009 年戈登赞助的抗原交叉展示会议
基本信息
- 批准号:7671922
- 负责人:
- 金额:$ 0.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-03-10 至 2010-03-09
- 项目状态:已结题
- 来源:
- 关键词:AddressAntigen Presentation PathwayAntigen-Presenting CellsAntigensAreaAutoimmunityBacteriaBacterial InfectionsBasic ScienceBiophysicsCD8B1 geneCell DeathCell surfaceCellsCellular biologyChronicClinicalClonal ExpansionCommunitiesComplexCross PresentationCross-PrimingCytotoxic T-LymphocytesDendritic CellsDevelopmentDisciplineDiseaseEffector CellEnvironmentGenerationsGenesGoalsHealthImmune responseImmune systemImmunityImmunobiologyImmunologyImmunotherapyInternationalInvestigationItalyLipidsLymphoidMHC Class I GenesMHC antigenMaintenanceMalignant NeoplasmsMembraneMolecularMolecular and Cellular BiologyOrganParticipantPathogenesisPathway interactionsPeptide/MHC ComplexPeptidesPhagocytesPhagocytosisProcessProteinsRegulationResearchResearch PersonnelRoleSeriesSignal TransductionT-LymphocyteTissue GraftsTranslational ResearchTumor TissueVaccinationViralVirusVirus Diseasesbasecancer immunotherapycell killingcytotoxicforgingmeetingsneuronal cell bodynovel strategiespathogenprogramsprotein foldingresponsesymposiumtumortumor immunologyuptakevaccination strategy
项目摘要
DESCRIPTION (provided by applicant): This proposal seeks partial support for an international conference on Antigen Cross-presentation as part f the Gordon Research Conference series to be held in Il Ciocco, Italy from June 14-19, 2009.The broad and long-term goal to develop and promote this conference emerged from the recognition that this ubiquitous pathway of antigen uptake, transport, and presentation represented a major research area for investigators from several distinct research perspectives, each of which would be served by having a venue in which they could come together to exchange ideas and move this important field forward in the very best traditions of the Gordon Research Conferences. The subject of antigen cross presentation presents an area of investigation that cuts across several scientific fields, including: Cell Biology; Cell Death; Dendritic Cell Immunobiology; Protein Folding; Lipid Biophysics; Signal Transduction; Antigen Processing and Presentation; and Translational Research including Tumor Immunology, Autoimmunity and Host/Pathogen Interactions. We recognize the need for increased interaction across these fields and see this meeting as an opportunity to build a community and forge new collaborative efforts.
Background: Cytotoxic T lymphocytes (CTLs) represent a critical component of the adaptive immune response against viruses, intracellular bacteria, and tumors through their ability to kill cells based on the proteins expressed in a target cell. To perform this task, naive CTLs must first be activated within secondary lymphoid organs by an antigen presenting cell (APC) expressing MHC class I/peptide complexes on its cell surface, causing it to undergo clonal expansion and functional differentiation. The resulting effector cells migrate to the periphery where they subsequently recognize the same peptide/MHC complexes on target cell and deliver the cytotoxic 'lethal hit'. In general, the peptides recognized on both APC and target cells are derived from antigens endogenously expressed within target cells. A long-standing paradox in immunology concerned how a professional phagocyte can prime responses against proteins expressed within a target cell. In the case of viral or bacterial infection, one might presume that the APC itself is directly infected with the same pathogen and thus can express the same genes as the infected target cell. In contrast, studies have shown that such responses are primed by uninfected APC, implying that the antigens in question must be taken up by the APC through phagocytosis, and the derived peptides somehow channeled into its own MHC class I presentation pathway, in essence crossing three membranes in the process. The same process guides the generation of effector CTL against tumors and tissue grafts, and has been referred to as 'cross-priming' while the uptake and processing of exogenous antigen for MHC I presentation by professional APC as 'cross-presentation.' The basic science aspects of how this pathway is regulated and the impact of these discoveries on disease pathogenesis and therapy is the focus of this GRC-sponsored meeting.
Aims: The specific aims of this meeting are to convene 37 speakers that represent critical areas of antigen cross presentation research with a total of 135 participants for a five-day conference in a relatively isolated setting. The program will feature a keynote address and eight sessions that will broadly address current issues in the cellular and molecular biology of antigen cross presentation, the instructive role of the innate immune system in modulating the context of antigen uptake and presentation, the responsive role of the adaptive immune system in cross-tolerance versus cross-priming, and importantly, the clinical perspectives on this process. The significance of this application is that the GRC-sponsored meeting on Antigen Cross presentation is a unique The health relatedness of this application is that as the cross presentation pathway has been shown to underlie the induction and maintenance of both CD8+ T cell immunity and tolerance to the overwhelming majority of cell-associated antigens, a deeper understanding of its specific mechanisms will allow for new approaches to the immunotherapy of cancer, chronic viral diseases, and cancer, and will aid in the development of superior vaccination strategies.
描述(由申请人提供):这项提议寻求部分支持将于2009年6月14-19日在意大利Il Ciocco举行的戈登研究会议系列会议的一部分的国际抗原交叉呈现会议。发展和促进这次会议的广泛和长期目标是因为认识到这一无处不在的抗原摄取、运输和呈现的途径代表着来自几个不同研究视角的研究人员的一个主要研究领域,每个研究角度都将通过一个他们可以聚集在一起交流思想的场所来实现,并在戈登研究会议的最好传统中推动这一重要领域向前发展。抗原交叉呈递是一个横跨多个科学领域的研究领域,包括:细胞生物学;细胞死亡;树突状细胞免疫生物学;蛋白质折叠;脂类生物物理学;信号转导;抗原处理和呈递;以及包括肿瘤免疫学、自身免疫和宿主/病原体相互作用在内的翻译研究。我们认识到在这些领域加强互动的必要性,并将此次会议视为建立社区和打造新的合作努力的机会。
背景:细胞毒性T淋巴细胞(CTL)是针对病毒、细胞内细菌和肿瘤的获得性免疫反应的重要组成部分,通过其基于靶细胞表达的蛋白质而杀死细胞的能力。为了完成这一任务,初级CTL必须首先在次级淋巴器官内被表达MHC I类/肽复合体的抗原提呈细胞(APC)激活,使其经历克隆性扩增和功能分化。由此产生的效应细胞迁移到外围,在那里它们随后识别目标细胞上相同的肽/MHC复合体,并提供细胞毒的“致命一击”。一般来说,APC和靶细胞上识别的多肽来自靶细胞内源性表达的抗原。免疫学中一个由来已久的悖论是关于专业吞噬细胞如何启动对靶细胞内表达的蛋白质的反应。在病毒或细菌感染的情况下,人们可能会假设APC本身直接感染了相同的病原体,因此可以表达与受感染的目标细胞相同的基因。相反,研究表明,这种反应是由未感染的APC启动的,这意味着有问题的抗原必须被APC通过吞噬作用摄取,并且衍生的多肽以某种方式引导到它自己的MHC I类递送途径,本质上在这个过程中穿过三个膜。同样的过程指导了针对肿瘤和组织移植的效应性CTL的产生,并被称为交叉启动,而专业APC对MHC I递呈的外源抗原的摄取和处理则称为交叉递呈。如何调控这一途径的基础科学方面,以及这些发现对疾病发病机制和治疗的影响是这次由GRC赞助的会议的重点。
目的:本次会议的具体目标是召集37位代表抗原交叉呈递研究关键领域的演讲者,总共135名与会者,在相对孤立的环境中举行为期五天的会议。该计划将以一次主旨演讲和八次会议为特色,广泛讨论抗原交叉呈递的细胞和分子生物学中的当前问题,先天免疫系统在调节抗原摄取和呈递上下文中的指导作用,适应性免疫系统在交叉耐受与交叉引发中的反应作用,以及重要的是,对这一过程的临床观点。这项应用的意义在于,由GRC赞助的抗原交叉呈递会议是一项与健康相关的独特会议,其与健康相关的是,由于交叉呈递途径已被证明是诱导和维持CD8+T细胞免疫和对绝大多数细胞相关抗原耐受的基础,对其具体机制的深入了解将使癌症、慢性病毒性疾病和癌症的免疫治疗的新方法成为可能,并将有助于开发更好的疫苗接种策略。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Stephen Philip Schoenberger其他文献
Stephen Philip Schoenberger的其他文献
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Local control of anti-tumor/anti-self reactivity in low-affinity ACT
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Local control of anti-tumor/anti-self reactivity in low-affinity ACT
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Cellular and Molecular Regulation of CD8+ T cell memory
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Cellular and Molecular Regulation of CD8+ T cell memory
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