2009 Molecular Pharmacology Gordon Research Conference

描述（由申请人提供）：本申请要求为2009年5月31日至6月5日在意大利巴尔加（比萨）的Il Ciocco会议中心举行的2009年戈登分子药理学研究会议提供资金。分子药理学戈登研究会议有着吸引该领域最优秀科学家的悠久历史。这是一个独特的论坛，聚集了来自学术界、政府和工业界的科学家，讨论信号转导研究、受体和其他药物靶点的最新前沿进展。会议的广泛目标一直是，并将继续是，通过在分子药理学的重要“增长领域”中提供综合方法来推动进展。2009年会议旨在整合分子药理学研究的两个主要方面，即基础和转化，通过使用实验和临床相关模型，突出药物受体和药物作用的分子机制和病理生理学影响的最新进展。虽然演讲者和会议主席将提供一个适合不太熟悉的与会者介绍，介绍将面向最新的，新颖的和未发表的发现。会议预计将吸引来自该领域的主要研究人员，预计将有约120名与会者，其中约85%将是学术研究人员。预计约25%将是研究生和博士后研究人员。大约25%的与会者将发言;其余的大多数将展示海报。2009年会议的具体目标之一是鼓励学生和博士后参与，并特别注意妇女和代表人数不足的少数群体成员的参与。2009年的计划将涵盖三个主要方面：i）受体的结构特征和单分子水平上受体功能的监测，ii）癌症，病毒感染，内分泌和心血管疾病的信号传导和调节网络，以及iii）探索行为，成瘾药物和代谢调节的小鼠模型。公共卫生相关性：本申请中提出的会议解决了可能具有直接临床相关性和应用的基础研究问题。分子药理学和临床医学之间存在着双向的信息传递：分子药理学阐明了药物作用的基本方面，并提供了在患者护理中有用的新的药理学工具，同时，临床医学中的病理生理学和治疗问题提出了新的问题，并引发了基础研究中的新假设。2009年会议的主题涉及许多领域，包括癌症、病毒感染、心血管和内分泌疾病以及行为和代谢调节。

DESCRIPTION (provided by applicant): This application requests funding for the 2009 Gordon Research Conference on Molecular Pharmacology to be held at Il Ciocco Conference Center in Barga (Pisa), Italy, May 31st-June 5th 2009. The Molecular Pharmacology Gordon Research Conference has a long history of attracting the best scientists in the field. It is a unique forum for the gathering of scientists from academia, government, and industry to discuss recent, cutting-edge advances in signal transduction research, receptors and other drug targets. The broad goal of the Conference has been, and continues to be, to advance progress by providing an integrated approach among important "growth areas" in Molecular Pharmacology. The 2009 Conference seeks to integrate two main aspects of research in molecular pharmacology, i.e. basic and translational, by highlighting recent advances in molecular mechanisms and pathophysiological implications of drug receptors and drug action through the use of experimental and clinically relevant models. Although speakers and session chairs will provide an introduction suited for the less-acquainted attendee, presentations will be geared to late-breaking, novel and unpublished findings. The conference is expected to attract leading investigators from the field and expected to have ~120 participants of whom ~85% will be academic researchers. Approximately 25% are expected to be graduate students and postdoctoral researchers. About 25% of the participants will speak; the majority of the remainder will present posters. Among the specific aims of the 2009 Conference is to encourage the participation of students and post-docs and to pay particular attention to the inclusion of women and members of underrepresented minorities. The 2009 program will cover three main aspects: i) structural features of receptors and monitoring of receptor function at single molecule level, ii) signaling and regulatory networks in cancer, viral infections, endocrine and cardiovascular disorders, and iii) murine models that explore behavior, drugs of addiction and regulation of metabolism. PUBLIC HEALTH RELEVANCE: The Conference proposed in this application addresses basic research questions that can have direct clinical relevance and applications. A bidirectional transfer of information exists between molecular pharmacology and clinical medicine: molecular pharmacology elucidates fundamental aspects of drug action and provides new pharmacological tools useful in patient care while in parallel, pathophysiological and therapeutic problems in clinical medicine raise new questions and trigger new hypotheses for testing in basic research studies. Topics at the 2009 Conference are relevant to a number of areas including cancer, viral infections, cardiovascular and endocrine disorders as well as behavior and regulation of metabolism.