2009 Gradient Sensing & Directed Cell Migration Gordon Research Conference

描述(申请人提供)：2009年戈登研究会议(GRC)关于梯度感应和定向细胞迁移将于2009年3月29日至4月3日在德克萨斯州加尔维斯顿的Galvez酒店举行。在这次会议之前，戈登在趋化研究领域成功地举行了两次会议，自2005年以来每两年举行一次。会议讨论了细胞如何在不同系统中极化和定向迁移的基础研究问题，包括发育、神经元路径寻找、白细胞运输、伤口愈合和组织修复以及癌症。这次会议还涉及旨在治疗细胞迁移对疾病发病机制至关重要的疾病的疗法的发展，包括心血管疾病、风湿性和过敏性疾病、哮喘和癌症。该计划强调了在不同系统背景下调节定向细胞迁移的机制的共性，以及这些共同途径对疾病发展的影响。会议将强调关于调节梯度感应和定向细胞迁移的基本机制的新概念，并将探索发育过程中的细胞迁移、伤口愈合、免疫细胞贩运和癌症之间的联系。计划的九个会议包括：(1)复杂系统中的定向细胞迁移，(2)发育和伤口愈合中的迁移，(3)炎症和白细胞的迁移，(4)趋化作用中的细胞信号，(5)免疫系统中的细胞极性和运动性，(6)细胞极性和细胞骨架的定向迁移，(7)细胞定向迁移中的建模和生物工程，(8)癌症中的定向细胞迁移，以及(9)神经元的极性和生长锥指导。演讲者和主题的组合是为了刺激趋化研究领域的新想法和合作而选择的。会议发言者将强调与梯度传感和不同领域的定向细胞迁移直接相关的新的未发表的结果。将鼓励年轻研究人员在支持性环境中介绍和讨论他们的调查结果，从提交的摘要中邀请多达20名演讲者，并举行四次海报会议。我们预计将提供财政支持，鼓励年轻科学家、妇女和代表性不足的少数群体参与。在整个会议期间，将在正式和非正式环境中促进高级和年轻调查人员之间的互动。对这一计划的支持将确保会议取得成功，并将为希望参加会议的杰出青年科学家提供急需的赞助。 公共卫生相关性：会议讨论了调节定向细胞迁移的基本机制。这一领域对于开发治疗包括心血管疾病、癌症、关节炎和哮喘在内的多种人类疾病的新疗法具有重要意义。关于梯度感应和定向细胞迁移的会议将汇集研究简单和复杂系统中定向细胞迁移的专家，以激发新的想法并提高我们改善公共卫生的能力。

DESCRIPTION (provided by applicant): The 2009 Gordon Research Conference (GRC) on Gradient sensing and directed cell migration will be held from March 29-April 3, 2009 at Hotel Galvez in Galveston, Texas. The conference follows two successful Gordon Conferences in the field of chemotaxis research, which have been held biennially since 2005. The conference addresses the basic research question of how cells polarize and migrate directionally in diverse systems, including development, neuronal path finding, leukocyte trafficking, wound healing and tissue repair and cancer. The conference is also relevant to the development of therapeutics aimed at disorders where cell migration is central to disease pathogenesis, including cardiovascular diseases, rheumatic and allergic disease, asthma and cancer. The program highlights the commonality of mechanisms that regulate directed cell migration in the context of diverse systems and the implications of these common pathways to the development of disease. The conference will emphasize new concepts about the basic mechanisms that regulate gradient sensing and directed cell migration, and will explore links between cell migration during development, wound healing, immune cell trafficking and cancer. Nine sessions are planned which include (1) Directed cell migration in complex systems, (2) Migration in development and wound healing, (3) Inflammation and leukocyte trafficking, (4) Cell signaling in chemotaxis, (5) Cell polarity and motility in the immune system, (6) Cell polarity and the cytoskeleton in directed cell migration, (7) Modeling and bioengineering in directed cell migration, (8) Directed cell migration in cancer, and (9) Neuronal polarity and growth cone guidance. The combination of speakers and topics has been selected with the specific intention of stimulating new ideas and collaborations in the field of chemotaxis research. The session speakers will emphasize novel unpublished results directly related to gradient sensing and directed cell migration in diverse fields. Young investigators will be encouraged to present and discuss their findings in a supportive environment, by inviting up to 20 additional speakers from submitted abstracts and by holding four poster sessions. We anticipate offering financial support to encourage participation by young scientists, women and underrepresented minorities. Throughout the conference, interaction among senior and young investigators will be promoted in both formal and informal settings. Support of this program will assure that the meeting will be successful and will provide much needed sponsorship for outstanding young scientists who wish to attend the meeting. PUBLIC HEALTH RELEVANCE: The conference addresses the fundamental mechanisms that regulate directed cell migration. This area has substantial importance to the development of new therapeutics to treat a diverse array of human diseases including cardiovascular disease, cancer, arthritis and asthma. The conference on Gradient sensing and directed cell migration will bring together experts that study directed cell migration in simple and complex systems in order to stimulate new ideas and advance our ability to improve public health.