Nuclear Sirtuins at the Interface between Epigenetic Regulation and Human Cytomegalovirus Pathogenesis: A Proteomics Perspective

表观遗传调控与人类巨细胞病毒发病机制之间界面的核 Sirtuins：蛋白质组学视角

• 批准号: nhmrc : 1037043
• 负责人: Dr Rommel Mathias
• 金额: $ 26.64万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nuclear-sirtuins-interface-proteomics-perspective/111042
• 关键词: Nuclear; Sirtuins; Interface; between; Epigenetic

Human cytomegalovirus (HCMV) is a human pathogen that infects over 60% of the adult population, and is a major cause of birth defects causing permanent hearing and vision loss, and mental retardation. To investigate the critical involvement of host epigenetic factors, I will study the roles of sirtuins during HCMV infection. Through proteomic, genomic, microscopy, and bioinformatic techniques, I aim to further our understanding of viral pathogenesis, towards developing novel therapies.

人类巨细胞病毒（HCMV）是一种人类病原体，感染超过60%的成年人，是导致出生缺陷、永久性听力和视力丧失以及智力迟钝的主要原因。为了研究宿主表观遗传因素的关键参与，我将研究sirtuins在HCMV感染中的作用。通过蛋白质组学、基因组学、显微镜学和生物信息学技术，我的目标是进一步了解病毒的发病机制，开发新的治疗方法。