Blocking Human Cytomegalovirus: Targeting Host Organelle Remodelling and the Viral Assembly Complex

阻断人类巨细胞病毒：针对宿主细胞器重塑和病毒组装复合体

• 批准号: nhmrc : 1100737
• 负责人: Dr Rommel Mathias
• 金额: $ 37.99万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/blocking-human-cytomegalovirus-assembly-complex/662525
• 关键词: Blocking; Human; Cytomegalovirus; Targeting; Host

Human cytomegalovirus (HCMV) is a human pathogen that infects over 60% of adults, is a significant cause of morbidity and mortality in immuno-compromised people, and a major cause of birth defects. Fundamental knowledge gaps remain in understanding host-pathogen relationships during infection. This project will systematically define molecular events giving rise to release of virus from an infected cell, and thereby reveal novel targets to block therapeutically.

人巨细胞病毒（HCMV）是一种感染超过60%成年人的人类病原体，是免疫功能低下人群发病和死亡的重要原因，也是出生缺陷的主要原因。在理解感染期间宿主-病原体关系方面仍然存在基本知识差距。该项目将系统地定义引起病毒从受感染细胞释放的分子事件，从而揭示治疗阻断的新靶点。