International Population Study on Macronutrients and BP - INTERMAP

关于常量营养素和血压的国际人口研究 - INTERMAP

• 批准号: 7910478
• 负责人: Martha L Daviglus
• 金额: $ 61.14万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7910478
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DESCRIPTION (provided by applicant): This application requests support for data analyses/ biochemical analyses - - particularly on foods/food groups/food subgroups/their combinations (patterns)/food preparation methods/eating patterns/food- related urinary metabolites and blood pressure (BP) (hypothesis testing and exploratory analyses) - - in the international cooperative INTERMAP Study. INTERMAP is a basic epidemiologic investigation on the role of dietary factors (foods/macro-/micronutrients)/ their urinary metabolites in the etiopatho- genesis population-wide of unfavorable BP levels, including the even more adverse BP patterns of lower socioeconomic (SES) population strata, particularly African-Americans. The multidisciplinary INTERMAP research effort -- based in Chicago and London -- aims to achieve a major advance on these important issues, in a highly cost effective way, based on its vast, unique, in-hand database for 4,680 men and women ages 40-59 from 17 population samples of diverse ethnicity/ SES/ eating practices in four countries (China, Japan, UK, USA). These high-quality standardized data are from four in-depth multi-pass 24-hour dietary recalls/person with computerization of all reported foods/ dietary supplements classified into 23 groups and 119 subgroups, their conversion into nutrients (total: 83); two timed 24-hour urine collections/person with measurement of 24-hour volume, Na, K, Ca, Mg, creatinine, urea, macro-/ microalbuminuria, 23 amino acids, nuclear magnetic resonance (NMR) metabolomic scanning for metabolites, eight BP measurements/person at four visits, height, weight, extensive questionnaire data. In 2003-2008 data were reported on influences of multiple individual macro-/micronutrients /urinary metabolites on BP, and on higher BP of lower SES Americans, and northern compared to southern Chinese. Specific aims for 2009-2014 involve elucidating influences on BP of multiple foods/ food groups/ food subgroups/ their combinations (patterns)/ food preparation methods/ eating patterns/food-related urinary metabolites. Primary hypotheses are on relation of 9 foods/ food groups to BP. Analyses are also to explore relations of food intakes/ eating patterns to urinary metabolites (metabolomic analyses), and role of these food/ eating/ metabolic factors in accounting for higher BP levels of lower SES Americans, African-Americans, and northern Chinese. Findings are to be used to estimate favorable impact on BP of multiple improvements in eating patterns by populations, i.e., to enhance dietary recommendations for primary prevention/ control of prehypertension/hypertension with consequence sizable reduction in cardiovascular disease risks. PUBLIC HEALTH RELEVANCE: LAY SUMMARY Normal blood pressure is rare among Americans ages 35 years and older. Adverse blood pressure levels are due to prevailing adverse lifestyles, first and foremost unfavorable dietary patterns. The ongoing INTERMAP Study, an international cooperative study of almost 5,000 women and men ages 40-59 from the United States, China, Japan, and the United Kingdom, has been investigating the specific details of the diet-blood pressure link. INTERMAP has already contributed to the current knowledge on the role of several specific dietary factors in influencing blood pressure adversely - - high salt intake, inadequate intakes of vegetable protein, potassium/calcium/magnesium/phosphorus/iron, and also overweight/obesity, excess alcohol consumption. During the next years (2009-2014), INTERMAP aims to focus in detail on multiple specific foods, food preparation and intake patterns, food influences on body metabolism and their relations to the population-wide blood pressure problem.

描述（由申请人提供）：本申请要求支持国际合作INTERMAP研究中的数据分析/生化分析-特别是食品/食品组/食品亚组/它们的组合（模式）/食品制备方法/饮食模式/与食物相关的尿代谢物和血压（BP）（假设检验和探索性分析）-。INTERMAP是一项基本的流行病学调查，研究饮食因素（食物/宏量/微量营养素）/它们的尿液代谢物在发病人群中不利的血压水平中的作用，包括更不利的血压模式的低社会经济（SES）人口阶层，特别是非洲裔美国人。INTERMAP的多学科研究工作——总部设在芝加哥和伦敦——旨在以一种高成本效益的方式在这些重要问题上取得重大进展，基于其庞大、独特、在手的数据库，该数据库来自四个国家（中国、日本、英国、美国）17个不同种族/社会地位/饮食习惯的人口样本，涵盖4680名年龄在40-59岁之间的男性和女性。这些高质量的标准化数据来自四次深入的多通道24小时膳食召回/人计算机化所有报告的食物/膳食补充剂分为23组和119亚组，它们转化为营养素（总数：83）；2次定时24小时尿液采集/人，测量24小时体积，Na， K, Ca, Mg，肌酐，尿素，大/微量蛋白尿，23种氨基酸，核磁共振（NMR）代谢组学扫描代谢物，8次血压测量/人4次就诊，身高，体重，广泛的问卷调查数据。2003-2008年的数据报道了多种个体宏量/微量营养素/尿液代谢物对血压的影响，以及低社会地位美国人的血压升高，以及中国北方人与南方人的血压升高。2009-2014年的具体目标包括阐明多种食物/食物组/食物亚组/它们的组合（模式）/食物制备方法/饮食模式/与食物相关的尿液代谢物对血压的影响。主要的假设是关于9种食物/食物组与BP的关系。分析还探讨了食物摄入/饮食模式与尿液代谢物的关系（代谢组学分析），以及这些食物/饮食/代谢因素在解释低社会地位美国人、非洲裔美国人和中国北方人的高血压水平中的作用。研究结果将用于估计人群饮食模式的多种改善对血压的有利影响，即加强对高血压前期/高血压初级预防/控制的饮食建议，从而显著降低心血管疾病风险。公共卫生相关性：LAY总结：正常血压在35岁及以上的美国人中是罕见的。不利的血压水平是由于普遍存在的不良生活方式，首先是不利的饮食模式。正在进行的INTERMAP研究是一项国际合作研究，研究对象是来自美国、中国、日本和英国的近5000名年龄在40-59岁之间的男女，该研究一直在调查饮食与血压之间联系的具体细节。INTERMAP已经提供了目前关于几种特定饮食因素对血压不利影响的作用的知识——高盐摄入量、植物蛋白、钾/钙/镁/磷/铁摄入量不足，以及超重/肥胖、过量饮酒。在接下来的几年中（2009-2014），INTERMAP的目标是详细关注多种特定食物，食物制备和摄入模式，食物对身体代谢的影响及其与人群血压问题的关系。