刺激平滑肌的血管活性肽-猫眼课题宝

刺激平滑肌的血管活性肽

批准号：

7915286

负责人：

ERVIN G ERDOS

金额：

$39.25万

依托单位：

UNIVERSITY OF ILLINOIS AT CHICAGO

依托单位国家：

美国

项目类别：

财政年份：

1993

资助国家：

美国

项目状态：

已结题

起止时间：

1993-09-30 至 2012-08-31

来源：

https://reporter.nih.gov/project-details/7915286

关键词：

Active Sites Agonist Anaphylatoxins Angiotensin I Angiotensin II Angiotensin-Converting Enzyme Inhibitors Angiotensins Antihypertensive Agents Aortic Rupture Arachidonic Acids Arsenicals BDKRB2 gene Binding Binding Sites Biological Assay Blood Blood Pressure Blood Vessels Bradykinin C-terminal Cardiovascular Diseases Cardiovascular system Catalytic Domain Cattle Cell surface Cells Chimeric Proteins Cleaved cell Complement 3a Complement 5a Complement Activation Complement component C4a Complex Creatine Kinase Critiques Diabetes Mellitus Diabetic Nephropathy Dimerization Drug effect disorder Endothelial Cells Enhancers Enzyme Activation Enzyme Inhibition Enzymes Epitopes Fibroblasts Figs - dietary Fluorescein Fluoresceins Fluorescence Resonance Energy Transfer Future G alpha q Protein Generations Grant Heart Heart failure Human Hydrolysis Hydrophobic Surfaces Hypertension Inflammatory Inositol Institutes Interleukin-4 Investigation Kidney Diseases Kininogens Kinins Label Laboratories Laboratory Animals Leadership Life Ligands Link Literature Lysine Carboxypeptidase MAPK11 gene Measures Mediating Mediator of activation protein Membrane Methods Mitogen-Activated Protein Kinases Molecular Molecular Genetics Mus Mutagenesis Mutate Myocardial Infarction N-terminal National Heart, Lung, and Blood Institute Nature Nitric Oxide Pathway interactions Patients Peptide Receptor Peptides Peptidyl-Dipeptidase A Pharmaceutical Preparations Phosphotransferases Pichia Plasma Prealbumin Process Production Progress Reports Prostaglandins Prostaglandins I Protein Isoforms Proteins Publications Publishing Receptor Signaling Recombinants Reporting Research Resistance Resolution Roentgen Rays Role Second Messenger Systems Signal Pathway Signal Transduction Site Site-Directed Mutagenesis Smooth Muscle Specificity Stroke Stromal Cells Structure Suggestion Syndrome System Techniques Therapeutic Therapeutic Agents Thromboxanes United States National Institutes of Health Universities Work X-Ray Crystallography Zinc analog base carboxypeptidase M cytokine extracellular glycosylation hypertension treatment inhibitor/antagonist inorganic phosphate mutant notch protein novel peptide analog preference protein kinase C epsilon receptor research study response second messenger single molecule stem

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中文摘要

翻译

我们正在申请续期我们的资助，由NHLBI持续支持了大约47年。这些目标源于我们对代谢肽的酶的初步研究，如缓激肽（BK）、血管紧张素等。血管紧张素I转换酶（kininase II； ACE）抑制剂目前用于治疗数百万高血压和各种心血管疾病患者。虽然它们的治疗作用被认为仅仅是由于阻断高血压血管紧张素I的产生和降压BK的失活，但ACE抑制剂通过间接和直接的作用模式增强了BK及其ACE耐药肽类似物对其受体（B2, B1）的作用。

英文摘要

We are applying for the renewal of our grant, continuously supported by NHLBI for about 47 years. The Aims stem from our initial investigations of enzymes that metabolize peptides such as bradykinin (BK), angiotensins and others. lilhibitors of angiotensin I converting enzyme (kininase II; ACE) are currently used to treat millions of patients with hypertension and various cardiovascular diseases. Although their therapeutic actions were thought to be due solely to blocking the generation of hypertensive angiotensin I and inactivation of hypotensive BK, ACE inhibitors enhance the effect of BK and its ACE-resistant peptide analogues on their receptors (B2, B1) by indirect and direct modes of actions.

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