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Vasoactive Peptides that Stimulate Smooth Muscles

Vasoactive Peptides that Stimulate Smooth Muscles
刺激平滑肌的血管活性肽
批准号：
7728646
负责人：
ERVIN G ERDOS
金额：
$39.25万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
1993
资助国家：
美国
项目状态：
已结题
起止时间：
1993-09-30 至 2011-08-31
来源：
https://reporter.nih.gov/project-details/7728646
关键词：
AgonistAngiotensin IAngiotensin IIAngiotensin-Converting Enzyme InhibitorsAngiotensinsAntihypertensive AgentsBindingBradykininCardiovascular DiseasesCell surfaceDevelopmentDiabetic NephropathyEndothelial CellsEnhancersEnzymesGenerationsGrantHeartHumanHydrophobic SurfacesHypertensionInvestigationKidney DiseasesKininsLigandsMediatingMolecularNational Heart, Lung, and Blood InstituteNitric OxideOutputPatientsPeptide ReceptorPeptidesPeptidyl-Dipeptidase APharmaceutical PreparationsReceptor ActivationReceptor SignalingResistanceRoentgen RaysSignal PathwaySignal TransductionSiteSmooth MuscleStructureTherapeuticTherapeutic AgentsZinccombathypertensive heart diseasenovelpeptide analogreceptorreceptor functionstem

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中文摘要
翻译
我们正在申请续期我们的资助，由NHLBI持续支持了大约47年。这些目标源于我们对代谢多肽的酶的初步研究，如缓激肽(BK)、血管紧张素和其他。血管紧张素I转换酶(Kininase II；ACE)的抑制剂目前用于治疗数百万高血压和各种心血管疾病患者。虽然它们的治疗作用仅被认为是由于阻断高血压血管紧张素I的产生和低血压BK的失活，但ACE抑制剂通过间接和直接的作用模式增强BK及其抗血管紧张素转换酶类似物对其受体(B2、B1)的作用。
英文摘要
We are applying for the renewal of our grant, continuously supported by NHLBI for about 47 years. The Aims stem from our initial investigations of enzymes that metabolize peptides such as bradykinin (BK), angiotensins and others. lilhibitors of angiotensin I converting enzyme (kininase II; ACE) are currently used to treat millions of patients with hypertension and various cardiovascular diseases. Although their therapeutic actions were thought to be due solely to blocking the generation of hypertensive angiotensin I and inactivation of hypotensive BK, ACE inhibitors enhance the effect of BK and its ACE-resistant peptide analogues on their receptors (B2, B1) by indirect and direct modes of actions.
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