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Intranasal Drug Delivery to Inhibit Glioma Angiogenesis and Invasion

Intranasal Drug Delivery to Inhibit Glioma Angiogenesis and Invasion
鼻内给药抑制胶质瘤血管生成和侵袭
批准号：
7895050
负责人：
DAVID ZAGZAG
金额：
$21.63万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-07-16 至 2012-06-30
来源：
https://reporter.nih.gov/project-details/7895050
关键词：
AMD3100AftercareAnatomyAngiogenesis InhibitorsAnimal ModelAnimalsAntibodiesApoptosisBindingBiologicalBlood VesselsBrainBrain NeoplasmsBromodeoxyuridineCXCR4 geneCellsCerebrospinal FluidClinicalComplexDC101 Monoclonal AntibodyDataDevelopmentDisease ProgressionDrug Delivery SystemsExtracellular MatrixFreezingGelatinase AGliomaGoalsGreen Fluorescent ProteinsHarvestHumanHypoxiaImmunohistochemistryIn Situ Nick-End LabelingIn VitroInfiltrative GrowthIntracranial NeoplasmsInvadedKnowledgeMalignant GliomaMethodsModelingMolecularMusNeuraxisNoscapineOralOutcomePatientsPatternPharmaceutical PreparationsPropertyRouteSystemTherapeutic AgentsTreatment ProtocolsTrigeminal nerve structureTumor AngiogenesisTumor Cell InvasionVascular Endothelial Growth Factor Receptor-2Vascular Endothelial Growth Factorsangiogenesisantitumor drugbevacizumabbrain tissueclinically relevantdrug efficacyefficacy testinghuman VEGF proteinhypoxia inducible factor 1improvedin vivoin vivo Modelmigrationmouse modelneoplastic cellneovascularizationneovasculaturenestin proteinneutralizing antibodynovelnovel therapeutic interventionnovel therapeuticsresearch studysmall moleculesubcutaneoustumortumor growthtumor progression

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