Intranasal Drug Delivery to Inhibit Glioma Angiogenesis and Invasion

鼻内给药抑制胶质瘤血管生成和侵袭

• 批准号: 7895050
• 负责人: DAVID ZAGZAG
• 金额: $ 21.63万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-16 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7895050
• 关键词: AMD3100; Aftercare; Anatomy; Angiogenesis Inhibitors; Animal Model; Animals; Antibodies; Apoptosis; Binding; Biological; Blood Vessels; Brain; Brain Neoplasms; Bromodeoxyuridine; CXCR4 gene; Cells; Cerebrospinal Fluid; Clinical; Complex; DC101 Monoclonal Antibody; Data; Development; Disease Progression; Drug Delivery Systems; Extracellular Matrix; Freezing; Gelatinase A; Glioma; Goals; Green Fluorescent Proteins; Harvest; Human; Hypoxia; Immunohistochemistry; In Situ Nick-End Labeling; In Vitro; Infiltrative Growth; Intracranial Neoplasms; Invaded; Knowledge; Malignant Glioma; Methods; Modeling; Molecular; Mus; Neuraxis; Noscapine; Oral; Outcome; Patients; Pattern; Pharmaceutical Preparations; Property; Route; System; Therapeutic Agents; Treatment Protocols; Trigeminal nerve structure; Tumor Angiogenesis; Tumor Cell Invasion; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factors; angiogenesis; antitumor drug; bevacizumab; brain tissue; clinically relevant; drug efficacy; efficacy testing; human VEGF protein; hypoxia inducible factor 1; improved; in vivo; in vivo Model; migration; mouse model; neoplastic cell; neovascularization; neovasculature; nestin protein; neutralizing antibody; novel; novel therapeutic intervention; novel therapeutics; research study; small molecule; subcutaneous; tumor; tumor growth; tumor progression

项目成果

CXCR7 is induced by hypoxia and mediates glioma cell migration towards SDF-1α.

• DOI: 10.1186/1471-2407-13-347
• 发表时间: 2013-07-17
• 期刊: BMC cancer
• 影响因子: 3.8
• 作者: Esencay M;Sarfraz Y;Zagzag D
• 通讯作者: Zagzag D