Dynamic Multi-Channel TMS with Reconfigurable Coil

具有可重构线圈的动态多通道 TMS

• 批准号: 7797413
• 负责人: Ji Chen
• 金额: $ 18.63万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7797413
• 关键词: Area; Behavior; Behavior Disorders; Brain; Brain region; Businesses; Cephalic; Collaborations; Complex; Computer Simulation; Computers; Development; Devices; Distant; Failure; Feedback; Goals; Institution; Lead; Location; Magnetism; Mood Disorders; Nature; Neurosciences; Pathway interactions; Patients; Pattern; Perception; Research; Research Personnel; Research Project Grants; Resolution; Role; Safety; Sensory; Site; Small Business Innovation Research Grant; Small Business Technology Transfer Research; Staging; Stimulus; Surface; System; Technology; Testing; Time; base; commercialization; cost; design; feeding; flexibility; human subject; magnetic field; novel; phantom model; prototype; public health relevance; relating to nervous system; research study

DESCRIPTION (provided by applicant): Most behaviors arise from complex interactions between distant anatomical areas. These areas receive neural information asynchronously in time. To investigate behavior while still maintaining the timing of information that occurs during real sensory stimulation, an external stimulation system with reasonable spatio-temporal resolution is needed. Current trans-cranial magnetic stimulation (TMS) technology is limited to single brain regions. The goal of the proposed research is to develop a novel TMS system based on multi-channel reconfigurable coils. With this hardware, researchers will be able to reproducibly stimulate multiple brain sites in any temporal order-in the same experiment and on a single experimental trial. This design has applications in basic neuroscience. We also anticipate that the dynamic TMS could be useful to treat mood disorders and other psychiatric problems. The proposed system will employ a wire-mesh coil, which will be constructed using several x-directional wires and several y-directional wires. By varying the current direction and/or strength on each wire, we can configure this mesh-wire coil into a standard loop coil and figure-8 coil of varying size. This provides maximum flexibility to the experimenter in that the location and extent of stimulation on the brain surface can be modified depending on experimental requirement. Moreover, one can dynamically and automatically modify the site(s) of stimulation several times within the span of seconds. By pre-storing various sequences of excitation patterns inside a control unit, one can explore the effect of dynamic TMS on behavior and as therapy. The specific objectives are: 1. To develop a prototype dynamic TMS device containing reconfigurable coils. 2. To test the ability of the reconfigurable coils to deliver focused magnetic fields of sufficient strength to selectively excite or inhibit selected brain regions in a phantom model. 3. To assess the safety and failure modes of the system. PUBLIC HEALTH RELEVANCE: We will develop a novel Transcranial Magnetic Stimulator (TMS) coil that can dynamically and automatically modify the site(s) of stimulation several times within the span of seconds.

描述（由申请人提供）：大多数行为源于遥远解剖区域之间的复杂相互作用。 这些区域接收神经信息的时间不同步。 为了研究行为，同时仍然保持在真实的感官刺激期间发生的信息的定时，需要具有合理的时空分辨率的外部刺激系统。 目前的经颅磁刺激（TMS）技术仅限于单个大脑区域。 本研究的目标是开发一种基于多通道可重构线圈的新型TMS系统。 有了这个硬件，研究人员将能够在同一个实验和一个单一的实验中，以任何时间顺序重复刺激多个大脑部位。 这种设计在基础神经科学中有应用。 我们还预计，动态TMS可能是有用的治疗情绪障碍和其他精神问题。 所提出的系统将采用金属丝网线圈，其将使用若干X方向导线和若干Y方向导线来构造。 通过改变每根导线上的电流方向和/或强度，我们可以将该网状导线线圈配置为不同尺寸的标准环形线圈和8字形线圈。 这为实验者提供了最大的灵活性，因为大脑表面上的刺激的位置和程度可以根据实验要求进行修改。 此外，可以在几秒的跨度内动态地和自动地修改刺激的部位数次。 通过在控制单元内预先存储各种序列的兴奋模式，可以探索动态TMS对行为和治疗的影响。 具体目标是：1. 开发一个包含可重构线圈的动态TMS装置原型。 2. 旨在测试可重构线圈输送足够强度的聚焦磁场的能力，以选择性地激发或抑制体模模型中选定的大脑区域。 3. 评估系统的安全性和故障模式。 公共卫生关系：我们将开发一种新型的经颅磁刺激器（TMS）线圈，可以在几秒钟内动态自动地多次修改刺激部位。