Computer-Assisted Cognitive Rehabilitation Intervention for Persons with MS

多发性硬化症患者的计算机辅助认知康复干预

• 批准号: 7742176
• 负责人: Alexa Stuifbergen
• 金额: $ 17.69万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7742176
• 关键词: Activities of Daily Living; Address; Attention; Axon; Behavior; Cells; Central Nervous System Diseases; Cessation of life; Clinical; Clinical Trials Design; Cognition; Cognitive; Cognitive deficits; Competence; Computer Assisted; Control Groups; Development; Disabled Persons; Disease; Distal; Emotional; Exercise; Future; Goals; Health behavior; Healthy People 2010; Home environment; Immune system; Impaired cognition; Individual; Intervention; Knowledge; Language; Life; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Memory; Motivation; Multiple Sclerosis; Myelin; NIH Program Announcements; Neuraxis; Neurologic; Neuropsychological Tests; Outcome; Participant; Pathologic; Perceived quality of life; Perception; Performance; Persons; Pharmaceutical Preparations; Physical activity; Problem Solving; Process; Quality of life; Randomized Clinical Trials; Reporting; Research; Research Design; Sampling; Self Efficacy; Societies; Structure; Symptoms; Techniques; Testing; Therapeutic Intervention; Time; Translating; United States; Waiting Lists; Woman; base; cognitive change; cognitive function; cognitive rehabilitation; depressive symptoms; design; executive function; experience; functional disability; group intervention; improved; innovation; intervention effect; mange; neuropsychological; novel; processing speed; programs; public health relevance; response; skills; stress management; theories

DESCRIPTION (provided by applicant): The effects of multiple sclerosis (MS) on cognition, thought to occur in 50-75% of persons with MS, have gained increasing recognition as one of the major disabling symptoms of the disease. While numerous studies have addressed the emotional and physical impact of MS, little attention has been given to strategies that might help manage the cognitive changes commonly experienced by persons with MS. The proposed study seeks to refine and test a novel computer-assisted cognitive rehabilitation intervention, MAPSS-MS (Memory, Attention, & Problem Solving Skills for persons with MS). The goal of this intervention is to help persons with MS maximize their cognitive functioning and develop skills and strategies to manage cognitive limitations. The MAPSS-MS has both a group component and an individual computer-assisted cognitive rehabilitation component. The group component of the intervention is designed to help participants improve self-efficacy for control of MS symptoms and use of compensatory strategies. The group intervention will be paired with an innovative computer-assisted cognitive rehabilitation (CACR) component that can be implemented in the participant's home. The CACR will assist individuals to develop attention, executive, memory and problem solving skills. The specific aims of this exploratory study are to: (1) Determine the feasibility of delivering the MAPPS- MS - an intervention to improve cognitive functioning for persons with MS; (2) Explore the effects of the "MAPPS-MS" intervention on cognitive performance (battery of neuropsychological tests), use of memory strategies, self-efficacy for control of MS, neuropsychological competence in activities of daily living, depressive symptoms, and perceived quality of life: and (3) Explore participant perceptions of the acceptability and usefulness of the MAPSS-MS intervention in their daily lives. The effects of the intervention on outcome variables will be assessed using a randomized clinical trial design with a wait list control group in a sample of 66 persons with MS. Measurements of study variables will occur at baseline, at 2 months (immediately after the MAPPS intervention), and at 5 months (3 months after the intervention is complete). Findings from this exploratory study will support future research designed to improve the cognitive functioning and quality of life of persons with MS. PUBLIC HEALTH RELEVANCE: Difficulties with cognitive functioning are common and disabling for persons with multiple sclerosis (MS). The proposed study will test a computer-assisted cognitive rehabilitation intervention that is designed to improve both cognitive performance and cognitive competence for functioning in everyday life.

描述(申请人提供)：多发性硬化症(MS)对认知的影响，被认为发生在50%-75%的MS患者中，已经越来越多地被认为是这种疾病的主要致残症状之一。虽然许多研究都讨论了多发性硬化症对情绪和身体的影响，但很少有人关注可能有助于管理多发性硬化症患者普遍经历的认知变化的策略。拟议的研究旨在完善和测试一种新型的计算机辅助认知康复干预，MAPSS-MS(多发性硬化症患者的记忆、注意力和解决问题的技能)。这项干预的目标是帮助多发性硬化症患者最大限度地发挥他们的认知功能，并发展管理认知局限性的技能和策略。MAPSS-MS既有团体部分，也有个人计算机辅助认知康复部分。干预的小组部分旨在帮助参与者提高控制多发性硬化症症状和使用代偿策略的自我效能。小组干预将与创新的计算机辅助认知康复(CACR)组件配对，该组件可以在参与者的家中实施。CACR将帮助个人发展注意力、执行力、记忆力和解决问题的技能。本探索性研究的具体目的是：(1)确定提供MAPPS-MS-一种改善MS患者认知功能的干预措施的可行性；(2)探讨MAPPS-MS干预对认知表现(成套神经心理测试)、记忆策略的使用、MS控制的自我效能、日常生活活动中的神经心理能力、抑郁症状和感知生活质量的影响；(3)探讨参与者对MAPSS-MS干预在日常生活中的可接受性和有效性的感知。研究变量的测量将在基线、MAPPS干预后2个月和5个月(干预完成后3个月)进行，将使用随机临床试验设计和等待名单对照组对66名MS患者样本进行干预对结果变量的影响。这项探索性研究的结果将支持未来旨在改善多发性硬化症患者认知功能和生活质量的研究：认知功能障碍在多发性硬化症患者中很常见，而且是致残的。这项拟议的研究将测试一种计算机辅助认知康复干预，旨在改善认知表现和日常生活中的认知能力。

项目成果

A randomized controlled trial of a cognitive rehabilitation intervention for persons with multiple sclerosis.

对多发性硬化症患者进行认知康复干预的随机对照试验。

• DOI: 10.1177/0269215511434997
• 发表时间: 2012-10
• 期刊: Clinical rehabilitation
• 影响因子: 3
• 作者: Stuifbergen AK;Becker H;Perez F;Morison J;Kullberg V;Todd A
• 通讯作者: Todd A

Home-Based Computer-Assisted Cognitive Training: Feasibility and Perceptions of People with Multiple Sclerosis.

家庭计算机辅助认知训练：多发性硬化症患者的可行性和看法。

• DOI: 10.7224/1537-2073-13.4.189
• 发表时间: 2011
• 期刊: International journal of MS care
• 作者: Stuifbergen,Alexa;Becker,Heather;Morgan,Stephanie;Morrison,Janet;Perez,Frank
• 通讯作者: Perez,Frank

Promising New Approaches to Assess Cognitive Functioning in People with Multiple Sclerosis.

评估多发性硬化症患者认知功能的有希望的新方法。

• DOI: 10.7224/1537-2073-14.2.71
• 发表时间: 2012
• 期刊: International journal of MS care
• 作者: Becker,Heather;Stuifbergen,Alexa;Morrison,Janet
• 通讯作者: Morrison,Janet