Small Animal Imaging Resource

描述(由申请者提供)：U24申请的总体目标是继续支持一支研究团队，为当地癌症研究人员开发新的和提供成熟的、最先进的高分辨率鼠标成像技术。哈佛小动物影像资源(SAIR)在分子成像和临床翻译方面的创新有着公认的记录，曾为70多名地区性癌症研究人员提供服务，目前为40多项与癌症相关的基础拨款进行成像研究。该计划隶属于两个NCI指定的癌症中心(Dana Farber哈佛癌症中心(DFHCC)和麻省理工学院癌症研究中心)和几个小鼠模型人类癌症联盟(MMHCC)。SAIR的具体目标是：1)增加高分辨率小鼠成像系统的可用性并扩大其类型；2)开发新的技术和方法来对特定癌症和器官的细胞和分子信息进行成像；3)协助获取图像；4)维护和确保成像设备的正确使用；5)协助图像分析、处理、量化、解释和图像融合；6)就a)小动物处理和监测、b)小动物成像和c)最好地利用成像设备阵列的具体细节来解决手头的具体问题，向调查人员和合作者提供培训。该计划的辅助核心包括病理学、化学、细胞和生物信息学核心。多学科培训将包括参与实践项目、研讨会和教学系列讲座。这项提议的总体重点是提供一个共享的资源和工具，使癌症研究人员能够将最先进的成像技术纳入他们的个人研究研究中。SAIR已经成为一个充满活力和多样化的资源，其中技术和思想的交流迅速发生，并促进了癌症研究中的跨学科合作。

DESCRIPTION (provided by applicant): The overall goal of this U24 application is to continue supporting a team of investigators to develop new and provide established, state-of-the-art high resolution mouse imaging techniques to local cancer investigators. The Harvard Small Animal Imaging Resource (SAIR) has a proven track record for innovation in molecular imaging and clinical translation, has served over 70 regional cancer investigators and currently performs imaging studies for over 40 cancer related base grants. The Program is affiliated with two NCI designated Cancer Centers (the Dana Farber Harvard Cancer Center (DFHCC) and the MIT Center for Cancer Research) and several Mouse Model of Human Cancer Consortia (MMHCC). The specific goals of the SAIR are to: 1) increase the availability and expand types of high resolution mouse imaging systems, 2) develop new techniques and methods to image cellular and molecular information of specific cancers and organs, 3) assist with image acquisition, 4) maintain and ensure the proper use of imaging equipment, 5) assist in image analysis, processing, quantitation, interpretation and image fusion and 6) provide training to investigators and collaborators with regard to a) small animal handling and monitoring, b) small animal imaging and c) the specifics of utilizing the array of imaging equipment best to address the specific questions at hand. Ancillary cores of this Program include a Pathology, Chemistry, Cell and Bioinformatics Cores. Multidisciplinary training will involve participation in hands-on projects, seminars and didactic lecture series. The overall focus of this proposal is to provide a shared resource and tools, which allow cancer researchers to incorporate state-of-the-art imaging technologies into their individual research studies. The SAIR has become a dynamic and diverse resource wherein exchange of techniques and ideas occurs rapidly and fosters interdisciplinary collaborations in cancer research.