A Data Resource for Analyzing Blood and Marrow Transplants

用于分析血液和骨髓移植的数据资源

• 批准号: 7919223
• 负责人: Mary Maresca Horowitz
• 金额: $ 55.97万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7919223
• 关键词: Address; Blood; Cell Transplantation; Clinical; Clinical Data; Clinical Research; Clinical Trials Network; Collaborations; Commit; Communities; Data; Databases; Development; Funding; Hematopoietic; Hematopoietic stem cells; International; Late Effects; Marrow; Methodology; Outcome; Play; Publications; Quality of life; Request for Applications; Research; Research Infrastructure; Research Personnel; Resources; Role; Technology; Therapeutic; Transplantation; clinical practice; data acquisition; data exchange; data sharing; electronic data; international center; meetings; programs; statistical center; success

The Center for International Blood and Marrow Transplant Research (CIBMTR) is a clinical research program dedicated to addressing important issues in hematopoietic cell transplantation (HCT) by offering a unique resource of data and statistical expertise to the scientific community. The CIBMTR includes > 400 HCT centers that share data on HCT outcomes and a Statistical Center that maintains a clinical database with information for more than 250,000 HCT recipients. These data and the analytic support available through the CIBMTR Statistical Center have led to successful completion of hundreds of studies.U24- CA76518 provides the primary support for these activities. This application requests funding for the next 5 years to support this resource in order to provide the biomedical community continued access to a high quality clinical database and statistical support to facilitate clinical research. Planned resource enhancements include development of electronic data acquisition technology to facilitate participation by a wide range of U.S.and non-U.S. HCT centers; collaboration with other domestic and international organizations to increase the data available to study transplantation for rare indications and new HCT technologies; collecting data on outcome of other therapeutic applications of hematopoietic stem cells; expanding data on late effects and long-term quality of life; and developing new biostatistical methodology to address the challenges, needs and opportunities in analyzing HCT outcomes. The CIBMTR is committed to meeting the needs of investigators in a rapidly evolving field. It has and will build on the infrastructure made possible by support from U24-CA76518 and partnership with others to better serve the research community. Activities during the current and previous funding cycles have led to not only many publications on important issues in HCT but also have created the opportunity for greatly expanded global collaboration in data exchange and observational HCT research and contributed substantially to the success of a U.S. multicenter clinical trials network in HCT. Enhancements already in progress and planned for the next funding cycle will allow more in-depth exploration of immunobiologic aspects of HCT and post-HCT QOL. In summary, the CIBMTR, with the support provided through U24-CA76518, continues to play a unique role in facilitating clinical research inHCT.

国际血液和骨髓移植研究中心（CIBMTR）是一个临床研究中心， 该计划致力于解决造血细胞移植（HCT）中的重要问题， 科学界的独特数据和统计专门知识资源。CIBMTR包括> 400 HCT中心共享HCT结局数据，统计中心维护临床数据库 为超过25万名HCT接受者提供信息。这些数据和分析支持 通过CIBMTR统计中心，成功完成了数百项研究。 CA 76518为这些活动提供了主要支持。该申请要求为未来5年提供资金 多年来支持这一资源，以提供生物医学界继续获得高 优质的临床数据库和统计支持，以促进临床研究。计划资源 加强措施包括发展电子数据收集技术，以方便 广泛的美国和非美国HCT中心;与其他国内和国际 组织增加用于研究罕见适应症和新HCT移植的数据 收集关于造血干细胞的其他治疗应用的结果的数据; 扩大关于迟发效应和长期生活质量的数据;开发新的生物统计方法， 应对分析HCT结果的挑战、需求和机遇。CIBMTR致力于 满足调查人员在快速发展领域的需求。它已经并将建立在基础设施上， 通过U24-CA 76518的支持以及与其他人的合作，可以更好地为研究社区服务。 在本供资周期和以往供资周期开展的活动不仅导致出版了许多关于重要的 这不仅为HCT中的问题提供了解决方案，而且也为大大扩大全球数据合作创造了机会。 交流和观察HCT研究，并为美国多中心的成功做出了重大贡献。 HCT的临床试验网络已经在进行的和计划在下一个供资周期进行的改进将 允许对HCT和HCT后QOL的免疫生物学方面进行更深入的探索。总而言之， CIBMTR在通过U24-CA 76518提供的支持下，继续在促进 HCT的临床研究。