Regenerative therapy following severe insults : Establishment of cell transplantation in the blood

本研究的目的是评估内皮细胞在各种严重损伤后的病理生理和再生反应，并研究各种干细胞在大鼠血管内移植的效果。间充质干细胞移植在多器官功能障碍大鼠模型中保护内皮细胞免受损伤并提高存活率。我们建立的共培养系统明确了间充质干细胞产生的一些再生因子直接抑制内皮损伤。我们还阐明了骨髓来源的单核细胞移植具有抗炎作用，并提高了大鼠挤压损伤模型的存活率。

The objectives of this study were to evaluate the pathophysiology and regenerative response of endothelium after various severe insults and to examine the effects of intravascular transplantation of various stem cells in rats. Transplantation of mesenchymal stem cells protect against endothelial damage and improve survival in a rat model with multiple organ dysfunction syndrome. Our established co-culture system clarified that some regenerative factors produced by mesenchymal stem cells directly inhibit the endothelial damage. We also clarified that transplantation of bone marrow derived mononuclear cells exerted anti-inflammatory effects and improved the survival in a rat model of crush injury.