Chemical, Structural, and Superstructural Determinants of Nanocarbon Toxicity

纳米碳毒性的化学、结构和上层结构决定因素

• 批准号: 7814469
• 负责人: Agnes B Kane
• 金额: $ 27.04万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-17 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7814469
• 关键词: 3-Dimensional; Adsorption; Area; Asbestos; Bioavailable; Biological Assay; Biological Models; Breathing; Caliber; Carbon; Carbon Nanotubes; Cell Culture Techniques; Cells; Charge; Chemicals; Chemistry; Chronic; Complex; Computer Systems Development; Conflict (Psychology); Devices; Dimensions; Drug Delivery Systems; Elasticity; Environmental Exposure; Exposure to; Fibrosis; Goals; Granuloma; Hand; Health; Housing; Human; Hydrophobicity; Imaging Techniques; In Vitro; Inflammation; Injury; Interdisciplinary Study; Lead; Length; Light; Liquid substance; Lung; Mediator of activation protein; Metals; Methods; Microscopic; Modeling; Molecular; Molecular Profiling; Morphology; Movement; Nanotechnology; Nanotubes; Occupational; Oxidation-Reduction; Pathologic; Pathologist; Population; Production; Property; Public Health; Reaction; Reference Standards; Relative (related person); Research; Risk; Rodent; Role; Sampling; Scientist; Screening procedure; Sepharose; Surface; Surface Properties; Testing; Tissues; Toxic effect; Toxicology; Tube; Universities; base; biological systems; carcinogenicity; chemical property; commercial application; commercialization; cytokine; cytotoxicity; design; genotoxicity; in vivo; innovation; interstitial; lung injury; nanofiber; nanomaterials; nanoscale; nanotoxicology; novel; oxidant stress; parent grant; public health relevance; response; self assembly; tool

DESCRIPTION (provided by applicant): Adverse human health effects due to occupational and environmental exposure to nanomaterials are a major concern and a potential threat to their successful commercialization and biomedical applications. Realization of their commercial potential will require a better understanding of the interactions of nanomaterials with biological systems and the development of new strategies to manage human health risk. Toxicological screening is urgently needed to identify potentially hazardous nanomaterials; however their wide variability and unique properties complicate interpretation of traditional in vitro and in vivo toxicity assays. An interdisciplinary research team at Brown University including a materials scientist, a toxicologic pathologist, and a molecular biologist has developed a panel of novel nanomaterials and innovative approaches for nanotoxicology assays. This panel of model nanomaterials will be expanded to include selected commercial materials subjected to rigorous characterization of toxicologically relevant materials propertied. The goal of this competitive revision is to identify the specific structural and surface properties of carbon nanotubes responsible for the genotoxicity and potential carcinogenicity following inhalation. Novel imaging techniques at the light microscopic and ultrastructural levels will be used to study the interaction of fibrous nanomaterials with dividing cells. PUBLIC HEALTH RELEVANCE: This research will lead to rational material design strategies for manufacturing of carbon nanotubes with minimal adverse human health impact.

描述（由申请人提供）：由于职业和环境暴露于纳米材料而对人类健康产生的不良影响是一个主要问题，也是对其成功商业化和生物医学应用的潜在威胁。实现其商业潜力将需要更好地了解纳米材料与生物系统的相互作用，并制定新的战略来管理人类健康风险。迫切需要进行毒理学筛选，以确定潜在的危险纳米材料;然而，它们的广泛变异性和独特性质使传统的体外和体内毒性测定的解释复杂化。布朗大学的一个跨学科研究小组，包括一名材料科学家，一名毒理学病理学家和一名分子生物学家，已经开发了一组新型纳米材料和创新的纳米毒理学检测方法。该模型纳米材料小组将扩大到包括经过毒理学相关材料特性严格表征的选定商业材料。本次竞争性修订的目标是确定碳纳米管的特定结构和表面特性，这些特性导致吸入后的遗传毒性和潜在致癌性。光学显微镜和超微结构水平的新型成像技术将用于研究纤维纳米材料与分裂细胞的相互作用。 公共卫生相关性：这项研究将导致合理的材料设计策略，用于制造对人类健康影响最小的碳纳米管。