Characterization of Floor Level Aerosol (PM) Exposure and Childhood Asthma

地面气溶胶 (PM) 暴露和儿童哮喘的特征

• 批准号: 7900103
• 负责人: Stuart Lloyd Shalat
• 金额: $ 5.23万
• 依托单位: UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-05 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7900103
• 关键词: Adult; Aerosols; Age; Airborne Particulate Matter; Allergens; Area; Asthma; Breathing; Caliber; Canis familiaris; Child; Childhood Asthma; Clinic; Dermatophagoides farinae antigen f 1; Devices; Endotoxins; Enrollment; Environmental Exposure; Exposure to; Felis catus; Floor; Frequencies; Glass; Height; Household; Laboratories; Life; Measurement; Measures; Methods; Molds; Monitor; Mus; Neighborhoods; Parents; Particle Size; Particulate; Pesticides; Play; Protocols documentation; Questionnaires; Reporting; Robotics; Sampling; Slide; Symptoms; Testing; Time; Toddler; age group; air sampling; cockroach allergen; computerized; early childhood; environmental particulate; experience; fungus; improved; instrument; monitoring device; particle; prototype; pyroglyphid; research study

DESCRIPTION (provided by applicant): A research study is proposed to refine and evaluate a new device to improve the estimation of indoor exposure to inhalable particulate for both children in the first year of life and toddlers. Because they frequently play on the floor, these children may experience significantly higher levels of exposure than older children and adults to PM10 particles and airborne constituents, which are known asthmagens. A total of 200 children ages 6 to 35 months will be enrolled from neighborhood clinics. Parents will be administered a standardized asthma questionnaire (ISAAC) to determine presence and frequency of asthma symtpoms. Exposures will be characterized both qualitatively and quantitatively, to examine if the more precise estimation of PM10 exposure obtained by using a surrogate for personal monitoring. The study will employ a revised iteration of a prototype Pre-Toddler Inhalable Particulate Environmental Robotic (PIPER) Sampler that has been developed and undergone preliminary testing. Sampling will be carried out with both a fixed height stationary sampling station, where inlets of all instruments will be at 110 cm height, and the self- propelled computerized PIPER sampler, where inlets of all instruments can be varied between 20 to 110cm above the floor to mirror the varied breathing heights of these children while engaged in play on the floor. Four parameters will be for each household: 1) mass concentration of PM10 particles measured by a real- time monitoring device; 2) real-time particle size and number distribution (0.3-10 urn); 3) air sampling on filters for detailed characterization of the PM10 constituents (pesticides, allergens, and endotoxins); 4) concentration and composition of airborne fungi (viable and non-viable) collected on glass slides. Measurements will be collected in tandem for each of the 4 types of monitoring. The results of the laboratory analysis for endotoxins, molds and allergens for cockroaches (Bla g Yz), dust mites (Der f 1/p 1), dog (Can f 1), cat (Pel d 1) and mouse (Mus ml) will be evaluated for association with reporting of asthma symptoms This study seeks to provide an alternative to personal monitoring for a variety of environmental exposures that may be experienced by children too young to be assessed by conventional methods, including those in their first year of life. In addition, it will open up an avenue for more precise estimation of early childhood exposures to asthmagens in the PM10 fraction of aerosols.

描述（由申请方提供）：拟进行一项研究，以完善和评价一种新装置，从而改善对一岁以下儿童和幼儿室内可吸入颗粒物暴露的估计。由于他们经常在地板上玩耍，这些儿童可能比年龄较大的儿童和成人暴露于PM10颗粒和空气中的成分（已知为哮喘原）的水平要高得多。共有200名6至35个月的儿童将从社区诊所登记。将对父母进行标准化哮喘问卷调查（ISAAC），以确定哮喘症状的存在和频率。暴露将定性和定量表征，以检查是否通过使用个人监测替代品获得更精确的PM10暴露估计。本研究将采用已开发并经过初步测试的幼儿可吸入颗粒物环境机器人（PIPER）采样器原型的修订版。将使用固定高度的固定采样站（所有仪器的入口高度为110 cm）和自行式计算机PIPER采样器（所有仪器的入口高度可在地板上方20至110 cm之间变化，以反映这些儿童在地板上玩耍时不同的呼吸高度）进行采样。每个家庭将有四个参数：1）由真实的实时监测装置测量的PM10颗粒物质量浓度; 2）实时颗粒物粒径和数量分布（0.3-10 μ m）; 3）在过滤器上进行空气采样，以详细表征PM10成分（杀虫剂、过敏原和内毒素）; 4）载玻片上收集的空气传播真菌（活的和非活的）的浓度和组成。对于4种类型的监测，将依次收集测量值。蟑螂内毒素、霉菌和过敏原的实验室检测结果（Bla g Yz），尘螨（Der f 1/p 1），狗（Can f 1），猫（Pel d 1）和小鼠（Mus ml）这项研究旨在提供一种替代个人监测的方法，以监测年龄太小的儿童可能经历的各种环境暴露。通过常规方法进行评估，包括出生后第一年的评估。此外，它将开辟一条途径，更精确地估计儿童早期暴露于气溶胶PM10部分中的哮喘。