Biostatistics

生物统计共享服务 生物统计共享服务的目标是提供基础、转化、临床和流行病学 马里兰州大学玛琳和斯图尔特格林鲍姆癌症中心（UMCCC）的研究人员， 获得高质量的统计科学。共享服务的功能包括设计、审查和 监测协议;统计分析、计划和报告;设计和分析高维 数据，包括微阵列基因表达，单核苷酸多态性（SNP），表观遗传学， 蛋白质组学;准备拨款申请和手稿;提供生物统计学培训和建议， 临床数据管理和数据库计算。生物统计共享服务为研究者提供 在UMCCC与先进的统计方法和专业知识下开发的其他赠款资助的 国家癌症研究所，如设计和分析组合研究，分析微阵列和 癌症流行病学数据和SNP数据挖掘。这项共享服务中的统计员与 UMCCC所有三个癌症项目的研究人员：实验治疗，激素反应 癌症，分子和结构生物学。共享服务可以访问出色的计算 资源和统计软件包（例如，SAS、StatXact、Splus）、数据库管理软件 (e.g., Access、Oncore）和专门的统计软件，以便高效和有效地支持 UGCC的节目。 2006年7月至2007年6月，这项共享服务为60名调查员的128个项目提供了支助， 42篇申请书将近55%的资金用于资助艾德癌症项目。为了这笔赠款， 我们要求0.50全职当量（FTE）的生物统计学和生物信息学支持和0.25 FTE的 行政和数据库援助，为每种癌症提供生物统计和生物信息学支持 在UMCCC。

Biostatistics Shared Service The goal of the Biostatistics Shared Service is to provide basic, translational, clinical, and epidemiology investigators at the University of Maryland Marlene and Stewart Greenebaum Cancer Center (UMGCC) with access to high quality statistical science. Functions of the shared service include designing, reviewing, and monitoring protocols; statistical analysis, planning, and reporting; designing and analyzing high dimensional data, including microarray gene expression, single nucleotide polymorphisms (SNPs), epigenetics, proteomics; preparing grant applications and manuscripts; providing biostatistics training and advice on clinical data management; and database computing. The Biostatistics Shared Service provides investigators at UMGCC with advanced statistical methods and expertise developed under other grants funded by the National Cancer Institute, such as design and analysis of combination studies, analysis of microarray and cancer epidemiology data, and SNP data mining. Statisticians in this shared service collaborate with investigators in all three cancer programs at UMGCC: Experimental Therapeutics, Hormone Responsive Cancers, and Molecular and Structural Biology. The shared service has access to excellent computing resources and statistical software packages (e.g., SAS, StatXact, Splus), database management software (e.g., Access, Oncore¿), and specialized statistical software necessary for efficient and effective support of UMGCC's programs. From July 2006 to June 2007, this shared service supported 128 projects from 60 investigators and 42 grant applications. Nearly 55 percent of total effort was spent on fund.ed cancer projects. For this grant, we request 0.50 full-time equivalent (FTE) of biostatistics and bioinformatics support and 0.25 FTE of administrative and database assistance to provide biostatistics and bioinformatics support to each cancer program at UMGCC.