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Mitochondrial Ceramide in Traumatic Brain Injury

Mitochondrial Ceramide in Traumatic Brain Injury
线粒体神经酰胺在脑外伤中的作用
批准号：
7748152
负责人：
Tatyana I. Gudz
金额：
$0.0万
依托单位：
RALPH H JOHNSON VA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-07-01 至 2012-06-30
来源：
https://reporter.nih.gov/project-details/7748152
关键词：
AccountingAfghanistanAmericanAnabolismApoptosisApoptoticBehavior TherapyBiochemicalBiological AssayBlast CellBrainBrain InjuriesCell DeathCell SurvivalCellsCellular StressCeramidesCerebrumCessation of lifeChemicalsComputersConflict (Psychology)ContusionsCore FacilityCoupledDataDetectionDevelopmentElementsEventFaceFunctional disorderGenerationsGlutamatesGoalsHeadHelmetHigh Pressure Liquid ChromatographyIndividualInjuryInvestigationIraqKnockout MiceLaboratoriesLeftLinkMAPK10 geneMagnetic Resonance ImagingMass Spectrum AnalysisMechanicsMediatingMediator of activation proteinMedicalMembraneMethodologyMethodsMitochondriaModelingMolecularMusNatureNeuronsOutcome MeasureOuter Mitochondrial MembranePatientsPhasePlayProcessProductionProtein IsoformsProteinsReactive Oxygen SpeciesRegulationRehabilitation therapyRespiratory ChainRoleSchemeSignal PathwaySmall Interfering RNASouth CarolinaSphingolipidsStimulusTestingTherapeuticTherapeutic InterventionToxic effectTransgenic MiceTraumatic Brain InjuryUniversitiesbasebiological adaptation to stressbrain tissuecell injuryclinically relevantcombatcontrolled cortical impactcytochrome cdihydroceramide desaturasehuman AMID proteinimprovedinhibitor/antagonistinjuredinsightinterdisciplinary approachionizationmitochondrial dysfunctionmouse modelnovelnovel strategiesnovel therapeutic interventionpro-apoptotic proteinprotein expressionresponsesmall hairpin RNAtandem mass spectrometry

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