Cedars-Sinai Biobank and Translational Research Core Facility (CS-BRCF)

雪松-西奈生物库和转化研究核心设施 (CS-BRCF)

• 批准号: 7935157
• 负责人: SHLOMO MELMED
• 金额: $ 955.29万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7935157
• 关键词: American; Archives; Arts; Capital; Caring; Computer software; Core Facility; Data; Employment; Free Will; Health Insurance Portability and Accountability Act; Human Resources; Laboratories; Link; Liquid substance; Maintenance; Medical; Medical Informatics; Medical center; Molecular; Morphology; Nitrogen; Occupations; Outcome; Pathologist; Patients; Phase; Privacy; Procedures; Process; Regulation; Research; Research Ethics Committees; Research Personnel; Research Project Grants; Retrieval; Secure; Silver; Specimen; System; Technology; Tissues; Translational Research; United States National Institutes of Health; Wages; base; biobank; cancer Biomedical Informatics Grid; design; operation; research facility; square foot; vapor

DESCRIPTION (provided by applicant): Cedars-Sinai Medical Center has recently completed a $15 million seismic upgrade to the SS Building (SSB), currently a mixed-use facility. We now request the NIH to partner with us to redirect space in SSB for translational research purposes. Specifically, we propose to renovate existing space to build a centralized, shared core biobank research facility: the Cedars-Sinai Biobank and Translational Research Core Facility (CS- BRCF). We have 4 objectives: 1) To create a core research facility to collect biospecimens prospectively for research use in a closely-supervised, standardized fashion using Best Practices; 2) To create a robust system- wide medical informatics platform that will link patient data and outcomes to each biospecimen using state-of- the-art capital software and hardware that is fully compliant with heightened regulatory and privacy requirements necessitated by GLP, GFP, HIPAA, and IRB regulations, enables "cradle to grave" tracking, and is compatible with the caBIG platform; 3) To create a Quality Assessment, Morphology, and Molecular Core Laboratory (QA-MMC) within the CS-BRCF that will characterize tissues specimens before archiving, provide pathologist expertise, perform analyte QA/QC, and deploy and refine optimal procedures for specimen acquisition, processing, archiving, and retrieval; and 4) To aggregate legacy biorepositories into a single controlled, secure facility. The proposed 6,322 net sq ft CS-BRCF will oversee and facilitate investigator access to biospecimens. Further, the CS-BRCF will optimize efficiencies of laboratory space and personnel utilization, which in turn will free up both space and personnel for re-deployment directly into research applications. The CS-BRCF will promote collaborative interactions among disparate investigators, and will thus stimulate research and grant applications. Sustainable design considerations are employed throughout the facility. Wherever possible, energy-inefficient freezers will be minimized or discarded in favor of more sustainable liquid nitrogen vapor-phase storage technology. We project that 9 jobs (median salary $85,000) will be created/sustained during the design and permitting phase, 66 jobs (median salary $55,000) will be created/sustained during the 10-month construction phase, and 11 long-term jobs (median salary $81,000) will be created upon beginning operations and maintained or expanded indefinitely. Operation and maintenance of the CS-BRCF will also create 9 new support jobs, with median salaries of $60,000. In total then, 95 American jobs will be created with total annual median salaries of $5,826,000. The CS-BRCF will thus create sustained employment, utilize "Green" technologies and design principles (projected LEED Silver rating), and accelerate the pace of the biospecimen-based translational research that will be centrally important in transitioning towards personalized medical care in the 21st century.

描述(由申请人提供)：锡达斯-西奈医疗中心最近完成了价值1500万美元的SS大楼(SSB)的地震升级，该大楼目前是一座综合用途设施。我们现在请求NIH与我们合作，将SSB中的空间重定向用于翻译研究目的。具体地说，我们建议翻新现有空间，以建立一个集中的、共享的核心生物库研究设施：锡达斯-西奈生物库和翻译研究核心设施(CS-BRCF)。我们有4个目标：1)创建一个核心研究设施，使用最佳实践以密切监督、标准化的方式前瞻性地收集生物标本以供研究使用；2)创建一个强大的系统范围的医疗信息学平台，使用最先进的资本软件和硬件将患者数据和结果与每个生物标本链接起来，该平台完全符合GLP、GFP、HIPAA和IRB法规所要求的更高的监管和隐私要求，能够进行“从摇篮到坟墓”的跟踪，并与caBIG平台兼容；3)在CS-BRCF内创建质量评估、形态和分子核心实验室(QA-MMC)，该实验室将在存档前对组织标本进行表征，提供病理学家的专业知识，执行分析物QA/QC，并部署和改进样本获取、处理、存档和检索的最佳程序；以及4)将遗留的生物库聚合到一个单一的受控、安全的设施中。拟议的6,322平方英尺净面积的CS-BRCF将监督和便利调查人员接触生物检疫。此外，CS-BRCF将优化实验室空间和人员利用的效率，这反过来将释放空间和人员，以便直接重新部署到研究应用中。CS-BRCF将促进不同研究人员之间的协作互动，从而刺激研究和批准申请。整个设施都采用了可持续设计的考虑因素。只要有可能，低能效的冰柜将被最小化或丢弃，转而采用更可持续的液氮气相存储技术。我们预计，在设计和审批阶段将创造/维持9个工作岗位(工资中位数$85,000)，在10个月的施工阶段将创造/维持66个工作岗位(工资中位数$55,000)，在开始运营后将创造11个长期工作岗位(工资中位数$81,000)，并无限期地维持或扩大。CS-BRCF的运营和维护还将创造9个新的支助职位，工资中位数为60,000美元。到那时，总共将创造95个美国就业机会，年平均工资总额为582.6万美元。因此，CS-BRCF将创造持续的就业机会，利用“绿色”技术和设计原则(预计LEED银级)，并加快基于生物样品的转化研究的步伐，这将对21世纪向个性化医疗过渡至关重要。