Cedars-Sinai Biobank and Translational Research Core Facility (CS-BRCF)

描述（由申请人提供）：雪松西奈医疗中心最近完成了1500万美元的SS大楼（SSB）的抗震升级，目前是一个混合用途的设施。我们现在请求NIH与我们合作，将SSB的空间重新定向为转化研究目的。具体来说，我们建议改造现有空间，建立一个集中的，共享的核心生物库研究设施：雪松西奈生物库和转化研究核心设施（CS-BRCF）。我们有四个目标：1）建立一个核心研究设施，采用最佳做法，在密切监督下，以标准化的方式前瞻性地收集生物标本用于研究; 2）创建一个强大的全系统医疗信息平台，该平台将使用最先进的资本软件和硬件将患者数据和结果与每个生物样本联系起来，该平台完全符合GLP、GFP、HIPAA所需的更高的监管和隐私要求，3）在CS-BRCF内创建质量评估、形态学和分子核心实验室（QA-MMC），该实验室将在存档前表征组织标本，提供病理学家专业知识，执行分析物QA/QC，并部署和完善标本采集、处理、存档和检索的最佳程序;和4）将传统生物储存库聚集到单个受控的安全设施中。拟议的6，322净平方英尺CS-BRCF将监督和促进研究者访问生物标本。此外，CS-BRCF将优化实验室空间和人员利用率，从而释放空间和人员，以便直接重新部署到研究应用中。CS-BRCF将促进不同研究人员之间的合作互动，从而刺激研究和赠款申请。可持续发展的设计考虑在整个设施。在可能的情况下，将尽量减少或放弃能源效率低下的冷冻机，以支持更可持续的液氮气相储存技术。我们预计在设计和许可阶段将创造/维持9个工作岗位（工资中位数为85，000美元），在10个月的施工阶段将创造/维持66个工作岗位（工资中位数为55，000美元），在开始运营后将创造11个长期工作岗位（工资中位数为81，000美元），并无限期维持或扩大。CS-BRCF的运营和维护还将创造9个新的支持性工作，工资中位数为60，000美元。届时，总共将创造95个美国就业岗位，年平均工资总额为582.6万美元。因此，CS-BRCF将创造持续的就业机会，利用“绿色”技术和设计原则（预计LEED银级），并加快基于生物制药的转化研究的步伐，这将是在21世纪向个性化医疗过渡的核心重要。

DESCRIPTION (provided by applicant): Cedars-Sinai Medical Center has recently completed a $15 million seismic upgrade to the SS Building (SSB), currently a mixed-use facility. We now request the NIH to partner with us to redirect space in SSB for translational research purposes. Specifically, we propose to renovate existing space to build a centralized, shared core biobank research facility: the Cedars-Sinai Biobank and Translational Research Core Facility (CS- BRCF). We have 4 objectives: 1) To create a core research facility to collect biospecimens prospectively for research use in a closely-supervised, standardized fashion using Best Practices; 2) To create a robust system- wide medical informatics platform that will link patient data and outcomes to each biospecimen using state-of- the-art capital software and hardware that is fully compliant with heightened regulatory and privacy requirements necessitated by GLP, GFP, HIPAA, and IRB regulations, enables "cradle to grave" tracking, and is compatible with the caBIG platform; 3) To create a Quality Assessment, Morphology, and Molecular Core Laboratory (QA-MMC) within the CS-BRCF that will characterize tissues specimens before archiving, provide pathologist expertise, perform analyte QA/QC, and deploy and refine optimal procedures for specimen acquisition, processing, archiving, and retrieval; and 4) To aggregate legacy biorepositories into a single controlled, secure facility. The proposed 6,322 net sq ft CS-BRCF will oversee and facilitate investigator access to biospecimens. Further, the CS-BRCF will optimize efficiencies of laboratory space and personnel utilization, which in turn will free up both space and personnel for re-deployment directly into research applications. The CS-BRCF will promote collaborative interactions among disparate investigators, and will thus stimulate research and grant applications. Sustainable design considerations are employed throughout the facility. Wherever possible, energy-inefficient freezers will be minimized or discarded in favor of more sustainable liquid nitrogen vapor-phase storage technology. We project that 9 jobs (median salary $85,000) will be created/sustained during the design and permitting phase, 66 jobs (median salary $55,000) will be created/sustained during the 10-month construction phase, and 11 long-term jobs (median salary $81,000) will be created upon beginning operations and maintained or expanded indefinitely. Operation and maintenance of the CS-BRCF will also create 9 new support jobs, with median salaries of $60,000. In total then, 95 American jobs will be created with total annual median salaries of $5,826,000. The CS-BRCF will thus create sustained employment, utilize "Green" technologies and design principles (projected LEED Silver rating), and accelerate the pace of the biospecimen-based translational research that will be centrally important in transitioning towards personalized medical care in the 21st century.