Integration of Core Facilities for Molecular and Cellular Characterization

分子和细胞表征核心设施的集成

基本信息

项目摘要

DESCRIPTION (provided by applicant): Oregon Health & Science University (OHSU) is requesting funds to renovate 5,431 gross square feet of core facilities space that will integrate two important research areas: flow cytometry and genomic analysis. The goal of this initiative is to improve facilities for molecular and cellular characterization. Specific Aim 1 consolidates space for the Flow Cytometry Center, which is currently scattered throughout the OHSU campus. Specific Aim 2 consolidates space for OHSU's microarray technologies and creates new space for a new Massively Parallel Sequencing Shared Resource that, with the Microarray Shared Resource, will constitute the a new Genomics Center at OHSU. Importantly, however, locating the Genomics Center adjacent to the Flow Cytometry Center will create scientific synergy by facilitating the generation of gene expression profiles and DNA variation measurements from pure cell populations. The proximity of these facilities will increase both the quality of service provided to investigators and the efficiencies by which these resources can integrate their synergistic activities. Integration of these resources will enable co- development of methods and technologies to minimize the number of cells required for array or sequencing assays, and the ability to rapidly hand off purified cells from the Flow Cytometry Shared Resource to the Genomics Center will minimize the chances of changes in gene expression profiles and enhance the potential to isolate intact/high quality RNA from smaller numbers of cells. Together, the aims of this proposal will greatly expand the resources for PHS-funded researchers at OHSU by creating sustainable efficiencies in the delivery of services and enhancing the capacity for scientific synergies. In addition, this proposal is expected to create 24 jobs during the renovation phase and will create the capacity to hire long-term scientific and technical staff.
描述(由申请人提供):俄勒冈州健康与科学大学(OHSU)正在申请资金,以翻新5,431总平方英尺的核心设施空间,将整合两个重要的研究领域:流式细胞术和基因组分析。该倡议的目标是改进分子和细胞表征设施。具体目标1巩固了流式细胞术中心的空间,该中心目前分散在OHSU校园内。具体目标2巩固了OHSU的微阵列技术的空间,并为新的大规模并行测序共享资源创造了新的空间,该资源将与微阵列共享资源一起构成OHSU的新基因组学中心。然而,重要的是,将基因组学中心定位在流式细胞术中心附近将通过促进纯细胞群的基因表达谱和DNA变异测量的生成来创造科学协同效应。这些设施的邻近性将提高向调查人员提供的服务质量,并提高这些资源整合其协同活动的效率。这些资源的整合将使方法和技术的共同开发能够最大限度地减少阵列或测序测定所需的细胞数量,并且将纯化细胞从流式细胞术共享资源快速移交给基因组学中心的能力将最大限度地减少基因表达谱变化的机会,并增强从较少数量的细胞中分离完整/高质量RNA的潜力。总之,该提案的目标将通过在提供服务方面创造可持续的效率和提高科学协同作用的能力,大大扩大OHSU由PHS资助的研究人员的资源。此外,该提案预计将在翻修阶段创造24个就业机会,并将创造雇用长期科学和技术工作人员的能力。

项目成果

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Daniel Michael Dorsa其他文献

Daniel Michael Dorsa的其他文献

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{{ truncateString('Daniel Michael Dorsa', 18)}}的其他基金

ASB1 Containment Expansion
ASB1 安全壳扩展
  • 批准号:
    8219232
  • 财政年份:
    2011
  • 资助金额:
    $ 438万
  • 项目类别:
EXTRAMURAL RESEARCH FACILITIES PROGRAM
校外研究设施计划
  • 批准号:
    7000790
  • 财政年份:
    2009
  • 资助金额:
    $ 438万
  • 项目类别:
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION
校外研究设施建设
  • 批准号:
    6830040
  • 财政年份:
    2004
  • 资助金额:
    $ 438万
  • 项目类别:
Human Subject Enhancement Program
人类受试者增强计划
  • 批准号:
    6591479
  • 财政年份:
    2002
  • 资助金额:
    $ 438万
  • 项目类别:
Scholars in Women's Health Research Across the Lifespan
女性一生健康研究的学者
  • 批准号:
    8132955
  • 财政年份:
    2002
  • 资助金额:
    $ 438万
  • 项目类别:
Oregon BIRCWH: Scholars in Women's Health Research Across the Lifespan
俄勒冈州 BIRCWH:女性一生健康研究的学者
  • 批准号:
    8721459
  • 财政年份:
    2002
  • 资助金额:
    $ 438万
  • 项目类别:
OHSU Human Subject Research Enhancement Program
OHSU 人类受试者研究增强计划
  • 批准号:
    6776870
  • 财政年份:
    2002
  • 资助金额:
    $ 438万
  • 项目类别:
Oregon BIRCWH: Scholars in Women's Health Research Across the Lifespan
俄勒冈州 BIRCWH:女性一生健康研究的学者
  • 批准号:
    8365937
  • 财政年份:
    2002
  • 资助金额:
    $ 438万
  • 项目类别:
Oregon BIRCWH: Scholars in Women's Health Research Across the Lifespan
俄勒冈州 BIRCWH:女性一生健康研究的学者
  • 批准号:
    8543746
  • 财政年份:
    2002
  • 资助金额:
    $ 438万
  • 项目类别:
Scholars in Women's Health Research Across the Lifespan
女性一生健康研究的学者
  • 批准号:
    7682929
  • 财政年份:
    2002
  • 资助金额:
    $ 438万
  • 项目类别:

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