EXTRAMURAL RESEARCH FACILITIES PROGRAM

描述(由申请人提供)： 俄勒冈健康与科学大学(OHSU)寻求资金，在俄勒冈州国家灵长类研究中心(ONPRC)建造新的户外团体住房以及诊所和医院支持设施。拟议的户外团体住房将被称为自然环境中的灵长类围栏(围栏)。研究的快速发展、无特定病原体(SPF)繁殖群体的扩大以及对美国农业部《非人灵长类动物环境改善政策草案》的遵守，需要为非人类灵长类动物(NHP)提供更多的社会住房和更多的动物中心支持空间。我们的长期目标是：1)在自然环境中为社会群体中的NHP提供住房；2)保护SPF印第安源恒河猴日益增长的种群；3)为越来越多的研究项目腾出笼子空间；以及4)提供最先进的中心诊所和医院支持设施，使ONPRC的所有NHP受益。为了实现这些目标，我们提议建造户外群体住房，称为围栏，为提高社会群体中的NHP提供一个自然环境，并满足SPF印度原生恒河猴扩大的需要，这是生物医学研究的宝贵资源。该设计包含了创新的功能，将为动物提供多种环境选择。每个围栏将由2,021个NSF室外草地围栏和478个NSF围栏组成，前者模拟自然环境，后者提供出色的保护，抵御恶劣天气，同时也用作饲料和捕鱼区。这6个单独的围栏每个将为40-60只恒河猴提供住所。我们还提议在六个围栏附近建造一个重要的、急需的诊所和医院支助设施。这将在目前位于校园对面的60个笼子诊所的基础上增加80个笼子。 具体目标1：为SPF猕猴繁育群体构建6个围栏。为ONPRC饲养健康的、天然富含SPF的猕猴，提供一个与大片长满草的户外区域围栏相连的加热封闭区域被认为是最好的方法。 具体目标2：在拟议的围栏附近建造一个2,344个NSF诊所和80个笼子的医院支助设施(具体目标1)，以提供急需的临床/支助空间。除了为六个围栏内最多360只恒河猴提供医疗设施外，它还将为拟议围栏附近的大约1,000只恒河猴提供急需的医院支持空间。

DESCRIPTION (provided by applicant): Oregon Health & Science University (OHSU) seeks funds to construct new outdoor group housing and a clinic and hospital support facility at the Oregon National Primate Research Center (ONPRC). The proposed outdoor group housing will be called the Primate Enclosures in a Natural Setting (PENS). Rapid research growth, expansion of Specific Pathogen Free (SPF) breeding colonies, and compliance with the USDA "Draft Policy on Environment Enhancement for Nonhuman Primates" necessitate additional social housing for nonhuman primates (NHPs) and increased animal central support space. Our long-term objectives are to: 1) provide housing for NHPs in social groups in a natural setting; 2) protect growing populations of SPF Indianorigin rhesus macaques; 3) free-up cage space for the growing number of research projects; and 4) provide state-of-the-art central clinic and hospital support facilities to benefit all NHPs at ONPRC. To accomplish these objectives, we are proposing to construct outdoor group housing, called PENS, to provide a natural setting in which to raise NHPs in social groups and to accommodate the need for expansion of the SPF Indian-origin rhesus macaques, which are an invaluable resource for biomedical research. The design incorporates innovative features that will offer animals multiple environmental choices. Each PENS will consist of a 2,021 NSF grassy Outdoor Area Enclosure to simulate a natural setting and a 478 NSF Enclosed Area Shelter that provides excellent protection against inclement weather and also serves as a feed and catch area. Each of the 6 individual PENS will provide housing for 40 - 60 rhesus monkeys. We are also proposing to construct an important and much needed Clinic and Hospital Support Facility located adjacent to the six PENS. This will add an additional 80 cages to the current 60-cage clinic located on the opposite side of the campus. Specific Aim 1: Construct 6 PENS for SPF rhesus macaque breeding colonies. Providing a heated Enclosed Area Shelter connected to a large grassy Outdoor Area Enclosure is thought to be the best means possible for the ONPRC to raise healthy, naturally enriched SPF rhesus macaques. Specific Aim 2: Construct a 2,344 NSF Clinic and 80-cage Hospital Support Facility adjacent to the proposed PENS (Specific Aim 1) to provide much needed clinical/support space. In addition to providing medical facilities for up to 360 rhesus to be housed in the six PENS, it will also provide much needed hospital support space for the approximately 1,000 rhesus located in corrals adjacent to the proposed PENS site.