Core Facilities Improvement: Forsyth Data Center Renovation

描述(由申请人提供)：口腔和颅面部疾病研究的世界领先者福赛斯研究所申请1218232美元，用于翻新其位于马萨诸塞州剑桥市第一街245号的新研究机构的606英尺2英寸的新数据中心核心。该数据中心将支持新的宿主-生物膜界面发现中心(CHBI)的研究，以及该研究所的许多其他基础和临床研究项目。随着我们准备为Forsyth BioInformation Core托管新的192核Beowulf集群，该项目代表着我们数据中心能力的显著扩展。目前正在进行一项积极的活动，招募新的年轻科学家作为首席研究人员，他们将与我们现有的研究优势协同工作，并将在理解人类如何与其微生物乘客共存健康以及宿主-生物膜界面的扰动如何导致疾病方面取得巨大的新进展。这些年轻的科学家将在以下领域拥有专业知识：人类遗传学/基因组学和蛋白质组学；唾液生物学；微生物-上皮相互作用；免疫系统的个体发育；粘膜表面的调节机制；共生关系的建立；微生物-矿化组织相互作用；以及临床/翻译研究，特别是与糖尿病、代谢综合征、肥胖、心血管疾病、炎症性肠道疾病、早产等的口腔-全身疾病相互作用有关的研究。CHBI将酌情进一步纳入新资助的哈佛大学范围内的CTSC(‘CATALYST’，http：calyst.atherard.edu)和哈佛系统生物学中心。Forsyth的资金将受到这一方案扩展的影响：14,267,072美元(46个正在进行的项目)和42(42)个未决项目(12,893,999美元)。据我们所知，CHBI在口腔健康领域将是独一无二的，并将使Forsyth将其在该领域的长期领导地位提升到一个新的水平。从2010年春季开始，Forsyth将开始对其位于马萨诸塞州剑桥第一街245号的新租赁设施进行重大翻新，该设施位于麻省理工学院附近的肯德尔广场地区。预计翻修工程将在夏季的大部分时间持续到秋季。该研究所将租用该空间至少15年，另外还有两个5年的选择。这保证了我们对翻新后的空间的长期占用。由于Forsyth现有计划的搬迁本身将独立于ARRA建设拨款资金而发生，因此此应用程序仅请求对新数据中心的支持，以便为我们的搬迁做准备。新的数据中心翻修工作已经准备就绪，必须在2010年秋季完工。该项目涉及在美国创造一些就业机会，包括如果这项申请获得资金，将立即产生大约11个就业机会的影响。

DESCRIPTION (provided by applicant): The Forsyth Institute, the world's leader in oral and craniofacial disease research, requests $1,218,232 to renovate 606 ft2 for a new state-of-the-art data center core at its new research facility at 245 First Street, Cambridge, MA. The data center will support the research of the new Center for Discovery at the Host-Biofilm Interface (CHBI) and many of the other basic and clinical research programs at the Institute. This project represents a significant expansion of our data center capabilities as we prepare to host the new 192- core Beowulf Cluster for the Forsyth Bioinformatics Core. An aggressive campaign is currently underway to recruit new young scientists as principal investigators who will synergize with our existing research strengths and will generate dramatic new advances in understanding how humans co-exist with their microbial passengers in health, and how perturbations at the host-biofilm interface lead to disease. These young scientists will have expertise in the following areas: human genetics/genomics and proteomics; salivary biology; microbial-epithelial interactions; ontogeny of the immune system; regulatory mechanisms at mucosal surfaces; establishment of commensalism; microbial-mineralized tissue interactions; and clinical/translational research particularly relating to oral-systemic disease interactions in diabetes, metabolic syndrome, obesity, cardiovascular disease, inflammatory bowel diseases, premature birth, and others. The CHBI will be further integrated as appropriate into the newly funded Harvard-wide CTSC ('CATALYST', http:catalyst.harvard.edu), and the Harvard Center for Systems Biology. The funding at Forsyth that will be impacted by this programmatic expansion is: $14,267,072 (46 active projects), and forty-two (42) pending projects ($12,893,999). To our knowledge, the CHBI will be unique in the field of oral health, and will allow Forsyth to bring its long leadership in this field to a new level. Beginning in the spring of 2010, Forsyth will begin significant renovation of its newly-leased facility located at 245 First Street, Cambridge MA located in the Kendall Square area near MIT. It is expected that renovations will continue through much of the summer and into the Fall. The Institute will lease the space for a minimum of 15 years, with two additional 5-year options. This guarantees our long-term occupancy of the renovated space. Because Forsyth's existing program relocation per se will occur independent of ARRA construction grant funding, this application requests support only for the new data center in preparation for our move. The new data center renovation is 'shovel ready' and must be completed in the Fall of 2010. The project involves some U.S. job creation including an immediate job impact of approximately 11 jobs created should this application be funded.