Resource Development Core

资源开发核心

• 批准号: 10754082
• 负责人: Eun Ji Chung
• 金额: $ 33.07万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10754082
• 关键词: Address; Adult; Architecture; Award; Biomedical Engineering; Cells; Chemistry; Collaborations; Communities; Complex; Data; Data Analyses; Deposition; Development; Ductal Epithelial Cell; Ecosystem; Engineering; Ensure; Fostering; Genome; Goals; Health; Human; IGA Glomerulonephritis; IgA Deficiency; Image; Incubators; Individual; Ions; Kidney; Kidney Diseases; Label; Leadership; Maps; Mass Spectrum Analysis; Methods; MicroRNAs; Microfluidics; Mission; Nephrons; Phenotype; Pilot Projects; Proteins; RNA; Research; Research Personnel; Resolution; Resource Development; Resources; Scientist; Series; Small Interfering RNA; Surface; Technology; Testing; Tissue imaging; Tissues; Universities; Validation; Work; biomedical resource; cell type; design; detection method; functional genomics; galactose receptor; genome-wide; improved; in vivo; innovation; interdisciplinary approach; kidney cell; mesangial cell; nanocarrier; nanomedicine; nanoparticle; nanoscale; physical science; podocyte; prevent; response; single cell technology; therapeutic target

SUMMARY - RESOURCE DEVELOPMENT CORE The Resource Development Core (RDC) is a major component of the proposed Northwestern University National Resource Center (NU-NRC), whose mission is to enable transformative kidney research through the application of physical sciences methods and approaches. The goal(s) of the RDC is to develop new and improved research resources that will be shared by the Biomedical Resource Core. Advances in single cell technologies have revealed the diversity of cell types that lie within the millions of nephrons residing within the adult human kidneys and their complex spatial and functional relationships. While this complexity has historically posed challenges in the development and delivery of therapies for kidney diseases, recent advances in physical science platforms and engineering technologies that consider tissue architecture, function and composition in their design provide powerful—yet severely underutilized—solutions to advance kidney research. The Resource Development Core will function as an incubator to advance emerging physical sciences technologies and validate their applicability, quality and impact as solutions for key challenges in kidney research. The RDC not only leverages Northwestern's powerhouse of physical scientists in nanomedicine, bioengineering and chemistry with demonstrated commitment to kidney research, it also brings a robust interdisciplinary approach and strong physical science presence into the kidney community. The goals of the RDC will be realized through the following 4 specific aims: 1. Establish an innovative and dynamic incubator focused initially on three pilot projects that will: advance nanomedicine approaches to deliver short RNAs to the kidney, develop microfluidic-based high throughput genome screens to identify therapeutic targets in the kidney and further develop platforms to allow spatial proteoform mapping of the kidney; 2. Establish a quarterly Incubator Think Tank to spur innovation and provide a forum to promote collaborations between physical scientists and kidney researchers to launch new pilot projects; 3. Foster robust validation of all new and improved resources; and 4. Collaborate with the consortium to prioritize resource availability and impact.

摘要--资源开发核心 资源开发核心(RDC)是拟建的西北大学的主要组成部分 国家资源中心(NU-NRC)，其使命是通过 物理科学方法和途径的应用。刚果民盟的目标(S)是开发新的 以及改进的研究资源，这些资源将由生物医学资源核心共享。 单细胞技术的进步揭示了数百万种细胞类型的多样性 位于成人肾脏内的肾单位及其复杂的空间和功能关系。 虽然这种复杂性在开发和提供治疗方法方面历史上构成了挑战 肾脏疾病，物理科学平台和工程技术的最新进展 在他们的设计中考虑到组织的结构、功能和组成提供了强大的-但严重的 未充分利用--促进肾脏研究的解决方案。资源开发核心将作为一个 促进新兴物理科学技术并验证其适用性、质量和 Impact作为肾脏研究中关键挑战的解决方案。RDC不仅利用西北大学的 物理科学家在纳米医学、生物工程和化学领域的强大力量 致力于肾脏研究，也带来了强大的跨学科方法和强大的物理科学 出现在肾脏社区中。区域发展委员会的目标将通过以下4个具体目标来实现 目标：1.建立一个创新和充满活力的孵化器，最初侧重于三个试点项目，这些项目将： 先进的纳米医学方法将短RNA输送到肾脏，开发基于微流控的高效 吞吐量基因组筛查以确定肾脏的治疗靶点，并进一步开发平台以允许 肾脏的空间蛋白质图谱；2.建立季度孵化器智库，以刺激创新 并提供一个论坛来促进物理学家和肾脏研究人员之间的合作 启动新的试点项目；3.促进对所有新的和改进的资源进行强有力的验证；以及4.与 财团对资源的可用性和影响进行优先排序。