Resource Development Core
资源开发核心
基本信息
- 批准号:10754082
- 负责人:
- 金额:$ 33.07万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2028-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultArchitectureAwardBiomedical EngineeringCellsChemistryCollaborationsCommunitiesComplexDataData AnalysesDepositionDevelopmentDuctal Epithelial CellEcosystemEngineeringEnsureFosteringGenomeGoalsHealthHumanIGA GlomerulonephritisIgA DeficiencyImageIncubatorsIndividualIonsKidneyKidney DiseasesLabelLeadershipMapsMass Spectrum AnalysisMethodsMicroRNAsMicrofluidicsMissionNephronsPhenotypePilot ProjectsProteinsRNAResearchResearch PersonnelResolutionResource DevelopmentResourcesScientistSeriesSmall Interfering RNASurfaceTechnologyTestingTissue imagingTissuesUniversitiesValidationWorkbiomedical resourcecell typedesigndetection methodfunctional genomicsgalactose receptorgenome-wideimprovedin vivoinnovationinterdisciplinary approachkidney cellmesangial cellnanocarriernanomedicinenanoparticlenanoscalephysical sciencepodocytepreventresponsesingle cell technologytherapeutic target
项目摘要
SUMMARY - RESOURCE DEVELOPMENT CORE
The Resource Development Core (RDC) is a major component of the proposed Northwestern University
National Resource Center (NU-NRC), whose mission is to enable transformative kidney research through
the application of physical sciences methods and approaches. The goal(s) of the RDC is to develop new
and improved research resources that will be shared by the Biomedical Resource Core.
Advances in single cell technologies have revealed the diversity of cell types that lie within the millions
of nephrons residing within the adult human kidneys and their complex spatial and functional relationships.
While this complexity has historically posed challenges in the development and delivery of therapies for
kidney diseases, recent advances in physical science platforms and engineering technologies that
consider tissue architecture, function and composition in their design provide powerful—yet severely
underutilized—solutions to advance kidney research. The Resource Development Core will function as an
incubator to advance emerging physical sciences technologies and validate their applicability, quality and
impact as solutions for key challenges in kidney research. The RDC not only leverages Northwestern's
powerhouse of physical scientists in nanomedicine, bioengineering and chemistry with demonstrated
commitment to kidney research, it also brings a robust interdisciplinary approach and strong physical science
presence into the kidney community. The goals of the RDC will be realized through the following 4 specific
aims: 1. Establish an innovative and dynamic incubator focused initially on three pilot projects that will:
advance nanomedicine approaches to deliver short RNAs to the kidney, develop microfluidic-based high
throughput genome screens to identify therapeutic targets in the kidney and further develop platforms to allow
spatial proteoform mapping of the kidney; 2. Establish a quarterly Incubator Think Tank to spur innovation
and provide a forum to promote collaborations between physical scientists and kidney researchers to
launch new pilot projects; 3. Foster robust validation of all new and improved resources; and 4. Collaborate with
the consortium to prioritize resource availability and impact.
总结——资源开发核心
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Eun Ji Chung其他文献
Eun Ji Chung的其他文献
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{{ truncateString('Eun Ji Chung', 18)}}的其他基金
Investigation of urinary extracellular vesicles as novel and safe therapeutics for autosomal recessive polycystic kidney disease
尿细胞外囊泡作为常染色体隐性遗传性多囊肾病的新型安全疗法的研究
- 批准号:
10750704 - 财政年份:2023
- 资助金额:
$ 33.07万 - 项目类别:
Multimodal Peptide Amphiphile Micelles for Atherosclerosis
用于治疗动脉粥样硬化的多模式肽两亲胶束
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9321402 - 财政年份:2015
- 资助金额:
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