Resource Development Core

资源开发核心

• 批准号: 10754082
• 负责人: Eun Ji Chung
• 金额: $ 33.07万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10754082
• 关键词: Address; Adult; Architecture; Award; Biomedical Engineering; Cells; Chemistry; Collaborations; Communities; Complex; Data; Data Analyses; Deposition; Development; Ductal Epithelial Cell; Ecosystem; Engineering; Ensure; Fostering; Genome; Goals; Health; Human; IGA Glomerulonephritis; IgA Deficiency; Image; Incubators; Individual; Ions; Kidney; Kidney Diseases; Label; Leadership; Maps; Mass Spectrum Analysis; Methods; MicroRNAs; Microfluidics; Mission; Nephrons; Phenotype; Pilot Projects; Proteins; RNA; Research; Research Personnel; Resolution; Resource Development; Resources; Scientist; Series; Small Interfering RNA; Surface; Technology; Testing; Tissue imaging; Tissues; Universities; Validation; Work; biomedical resource; cell type; design; detection method; functional genomics; galactose receptor; genome-wide; improved; in vivo; innovation; interdisciplinary approach; kidney cell; mesangial cell; nanocarrier; nanomedicine; nanoparticle; nanoscale; physical science; podocyte; prevent; response; single cell technology; therapeutic target

SUMMARY - RESOURCE DEVELOPMENT CORE The Resource Development Core (RDC) is a major component of the proposed Northwestern University National Resource Center (NU-NRC), whose mission is to enable transformative kidney research through the application of physical sciences methods and approaches. The goal(s) of the RDC is to develop new and improved research resources that will be shared by the Biomedical Resource Core. Advances in single cell technologies have revealed the diversity of cell types that lie within the millions of nephrons residing within the adult human kidneys and their complex spatial and functional relationships. While this complexity has historically posed challenges in the development and delivery of therapies for kidney diseases, recent advances in physical science platforms and engineering technologies that consider tissue architecture, function and composition in their design provide powerful—yet severely underutilized—solutions to advance kidney research. The Resource Development Core will function as an incubator to advance emerging physical sciences technologies and validate their applicability, quality and impact as solutions for key challenges in kidney research. The RDC not only leverages Northwestern's powerhouse of physical scientists in nanomedicine, bioengineering and chemistry with demonstrated commitment to kidney research, it also brings a robust interdisciplinary approach and strong physical science presence into the kidney community. The goals of the RDC will be realized through the following 4 specific aims: 1. Establish an innovative and dynamic incubator focused initially on three pilot projects that will: advance nanomedicine approaches to deliver short RNAs to the kidney, develop microfluidic-based high throughput genome screens to identify therapeutic targets in the kidney and further develop platforms to allow spatial proteoform mapping of the kidney; 2. Establish a quarterly Incubator Think Tank to spur innovation and provide a forum to promote collaborations between physical scientists and kidney researchers to launch new pilot projects; 3. Foster robust validation of all new and improved resources; and 4. Collaborate with the consortium to prioritize resource availability and impact.

摘要 - 资源开发核心 资源开发核心（RDC）是拟议的西北大学的主要组成部分 国家资源中心 (NU-NRC)，其使命是通过以下方式实现变革性肾脏研究： 物理科学方法和途径的应用。 RDC 的目标是开发新的 并改进将由生物医学资源核心共享的研究资源。 单细胞技术的进步揭示了数百万细胞类型的多样性 居住在成人肾脏内的肾单位及其复杂的空间和功能关系。 虽然这种复杂性历来给治疗方法的开发和提供带来了挑战 肾脏疾病、物理科学平台和工程技术的最新进展 在设计中考虑组织结构、功能和组成，提供强大但严格的 未充分利用——推进肾脏研究的解决方案。资源开发核心将充当 孵化器推进新兴物理科学技术并验证其适用性、质量和 作为肾脏研究关键挑战的解决方案的影响。 RDC 不仅利用了西北大学的 纳米医学、生物工程和化学领域物理科学家的强国 对肾脏研究的承诺，它还带来了强大的跨学科方法和强大的物理科学 进入肾脏界。 RDC的目标将通过以下4个具体目标来实现 目标： 1. 建立一个创新且充满活力的孵化器，最初重点关注三个试点项目，这些项目将： 先进的纳米医学方法将短 RNA 递送至肾脏，开发基于微流体的高 通过基因组筛选来识别肾脏中的治疗靶点并进一步开发平台以允许 肾脏的空间蛋白质图谱； 2. 按季度建立孵化器智库，激励创新 并提供一个论坛来促进物理科学家和肾脏研究人员之间的合作 启动新的试点项目； 3. 促进对所有新资源和改进资源的强有力验证； 4. 与以下机构合作 联盟优先考虑资源的可用性和影响。