Resource Development Core

资源开发核心

• 批准号: 10754082
• 负责人: Eun Ji Chung
• 金额: $ 33.07万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10754082
• 关键词: Address; Adult; Architecture; Award; Biomedical Engineering; Cells; Chemistry; Collaborations; Communities; Complex; Data; Data Analyses; Deposition; Development; Ductal Epithelial Cell; Ecosystem; Engineering; Ensure; Fostering; Genome; Goals; Health; Human; IGA Glomerulonephritis; IgA Deficiency; Image; Incubators; Individual; Ions; Kidney; Kidney Diseases; Label; Leadership; Maps; Mass Spectrum Analysis; Methods; MicroRNAs; Microfluidics; Mission; Nephrons; Phenotype; Pilot Projects; Proteins; RNA; Research; Research Personnel; Resolution; Resource Development; Resources; Scientist; Series; Small Interfering RNA; Surface; Technology; Testing; Tissue imaging; Tissues; Universities; Validation; Work; biomedical resource; cell type; design; detection method; functional genomics; galactose receptor; genome-wide; improved; in vivo; innovation; interdisciplinary approach; kidney cell; mesangial cell; nanocarrier; nanomedicine; nanoparticle; nanoscale; physical science; podocyte; prevent; response; single cell technology; therapeutic target

SUMMARY - RESOURCE DEVELOPMENT CORE The Resource Development Core (RDC) is a major component of the proposed Northwestern University National Resource Center (NU-NRC), whose mission is to enable transformative kidney research through the application of physical sciences methods and approaches. The goal(s) of the RDC is to develop new and improved research resources that will be shared by the Biomedical Resource Core. Advances in single cell technologies have revealed the diversity of cell types that lie within the millions of nephrons residing within the adult human kidneys and their complex spatial and functional relationships. While this complexity has historically posed challenges in the development and delivery of therapies for kidney diseases, recent advances in physical science platforms and engineering technologies that consider tissue architecture, function and composition in their design provide powerful—yet severely underutilized—solutions to advance kidney research. The Resource Development Core will function as an incubator to advance emerging physical sciences technologies and validate their applicability, quality and impact as solutions for key challenges in kidney research. The RDC not only leverages Northwestern's powerhouse of physical scientists in nanomedicine, bioengineering and chemistry with demonstrated commitment to kidney research, it also brings a robust interdisciplinary approach and strong physical science presence into the kidney community. The goals of the RDC will be realized through the following 4 specific aims: 1. Establish an innovative and dynamic incubator focused initially on three pilot projects that will: advance nanomedicine approaches to deliver short RNAs to the kidney, develop microfluidic-based high throughput genome screens to identify therapeutic targets in the kidney and further develop platforms to allow spatial proteoform mapping of the kidney; 2. Establish a quarterly Incubator Think Tank to spur innovation and provide a forum to promote collaborations between physical scientists and kidney researchers to launch new pilot projects; 3. Foster robust validation of all new and improved resources; and 4. Collaborate with the consortium to prioritize resource availability and impact.

摘要----资源开发核心 资源开发核心（RDC）是拟议中的西北大学的主要组成部分 国家资源中心（NU-NRC），其使命是通过以下方式实现变革性肾脏研究： 物理科学方法和途径的应用。RDC的目标是开发新的 和改进的研究资源，将由生物医学资源核心共享。 单细胞技术的进步揭示了细胞类型的多样性， 的肾单位居住在成人肾脏和它们复杂的空间和功能关系。 虽然这种复杂性在历史上对治疗的开发和提供提出了挑战， 肾脏疾病、物理科学平台和工程技术的最新进展， 在其设计中考虑组织结构、功能和组成， 未充分利用的解决方案，以推进肾脏研究。资源开发核心将作为一个 孵化器，以推动新兴的物理科学技术，并验证其适用性，质量和 作为肾脏研究关键挑战的解决方案。RDC不仅利用西北大学的 纳米医学、生物工程和化学领域的物理科学家， 致力于肾脏研究，它还带来了强大的跨学科方法和强大的物理科学 进入肾脏社区。区域发展委员会的目标将通过以下4个具体方面实现 目标：1.建立一个创新和充满活力的孵化器，最初侧重于三个试点项目，这些项目将： 推进纳米医学方法，将短RNA输送到肾脏，开发基于微流体的高通量 通过基因组筛选来鉴定肾脏中的治疗靶点，并进一步开发平台， 肾脏的空间蛋白质型映射; 2.建立季度孵化器智库以刺激创新 并提供一个论坛，以促进物理科学家和肾脏研究人员之间的合作， 开展新的试点项目; 3.促进对所有新的和改进的资源进行强有力的验证;以及4.协作 联合体确定资源可用性和影响的优先次序。