The Molecular Mechanisms of Immune Cell Development and Function

免疫细胞发育和功能的分子机制

• 批准号: 10751580
• 负责人: Amy Susan Weinmann
• 金额: $ 1.15万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-11 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10751580
• 关键词: American; Antigen Receptors; Architecture; Area; Autoimmunity; B-Cell Development; Biological; Biological Models; Biology; California; Canada; Career Mobility; Cells; Characteristics; Clinical; Collaborations; DNA Repair; Development; Developmental Process; Disease; Educational workshop; Effector Cell; Environment; Epigenetic Process; Evaluation; Event; Faculty; Feedback; Financial Support; Fostering; Functional disorder; Funding; Future; Gene Expression; Gene Expression Regulation; Gene Rearrangement; Genes; Genetic Recombination; Genome; Genomic DNA; Genomics; Goals; Health; Hematopoietic; Hematopoietic stem cells; Human; Immune; Immune response; Immune system; Immunologic Receptors; Immunology; Immunooncology; Individual; Innate Immune Response; International; Island; Knowledge; Laboratories; Lymphoid Tissue; Malignant Neoplasms; Mentors; Metabolic; Modeling; Molecular; Molecular Biology; Molecular Immunology; Nova Scotia; Oncology; Pattern; Persons; Postdoctoral Fellow; Process; Receptor Gene; Regulation; Request for Proposals; Research; Research Personnel; Science; Scientist; Senior Scientist; Series; Signal Pathway; Signal Transduction; Societies; System; T cell differentiation; Time; Training; Transcriptional Regulation; Travel; United States National Institutes of Health; Woman; Work; adaptive immune response; biological research; career; career development; design; epigenetic regulation; experience; gene network; genome integrity; genome-wide; graduate student; gut homeostasis; immune function; immunoregulation; insight; intestinal homeostasis; lymphoid organ; meetings; pandemic disease; posters; pre-doctoral; programs; response; scientific atmosphere; stem cells; symposium; synergism; thymocyte; tumor

PROJECT SUMMARY This proposal requests partial support for a 2023 Science Research Conference (SRC) sponsored by the Federation of American Societies for Experimental Biology (FASEB) on the subject of “Molecular Mechanisms of Immune Cell Development and Function”, the 11th conference in this highly successful series. This conference has been chosen for sponsorship by FASEB after a competitive re-evaluation every other year since its inception in summer 2003. The distinctive features of this conference are: (1) A strong emphasis on molecular biology of gene regulation in immune cell development and function, including new insights emerging from genome-wide and systems approaches; (2) Close integration of the study of molecular mechanisms of immune receptor gene recombination and diversification with concepts in genomic architecture and long-range genomic control; (3) Deliberate juxtaposition of research on different classes of immune cells to reveal larger patterns of shared use of molecular and developmental mechanisms; (4) An explicit focus on gene network and signaling network connections rather than “one gene at a time” studies to provide a comprehensive explanation of biological regulation; (5) Creation of sessions that integrate the major molecular/mechanistic themes of the meeting with immuno-oncology, gut homeostasis, and autoimmunity; (6) Integration of presentations from scientists at many career levels, from internationally renowned experts to junior postdoctoral fellows and graduate students, in an intensive, all-plenary program—allowing trainees easy access to experienced senior scientists who in turn gain an appreciation of the young people’s impact on the field, and (7) Implementation of our unique financial model in which invited speakers forego financial support for their participation to allow the use of the majority of funds to support trainees and young investigators who are establishing their independent careers. These distinctive features are designed around three specific aims: Aim 1—To disseminate the most recent and important advances and new paradigms in molecular immunology; Aim 2—To create a highly interactive, supportive, and collegial environment for the sharing of scientific knowledge between scientists at many different stages of training and career development, thereby facilitating new collaborations, broadening of professional and mentoring networks, and career development; and Aim 3—To enhance diversity among the individuals who participate in, contribute to, and achieve career advancement in the field of immunology and biological research more broadly. The support requested is crucial to make it possible for the most promising trainees and junior faculty in molecular immunology to publicly present their work in plenary sessions and interact in a small setting with leaders in their field. This meeting has received enthusiastic feedback from conference attendees of previous meetings, giving it a strong mandate for long-term continuation.

项目摘要 该建议要求部分支持2023年的科学研究会议（SRC） 美国实验生物学联合会（FASEB）关于“分子机制的主题） 这个非常成功的系列赛的第11届会议的免疫细胞开发和功能。 自成立以来，每隔一年一次重新评估一次竞争性重新评估后，已选择赞助 在2003年夏季。这次会议的独特特征是：（1）非常强调 免疫细胞发育和功能中的基因调节，包括全基因组出现的新见解 和系统方法； （2）紧密整合免疫受体基因的分子机制 重组和多样化，具有基因组结构和远程基因组控制中的概念； （3） 故意对不同类别的免疫细胞的研究并置，以揭示更大的共享使用模式 分子和发育机制； （4）明确关注基因网络和信号网络 连接而不是“一次基因”研究，以提供对生物学的全面解释 规定; （5）创建将会议的主要分子/机械主题与之相结合的会议 免疫肿瘤学，肠道稳态和自身免疫性； （6）许多科学家的演讲整合 从国际知名的专家到初级博士后研究员和研究生的职业水平， 密集的全样计划 - 允许学员轻松进入经验丰富的高级科学家 对年轻人对该领域的影响的欣赏，以及（7）实施我们独特的财务模型 在其中邀请发言人放弃参与的财政支持，以允许使用大多数资金 支持建立独立职业的受训者和年轻的调查员。这些独特的 功能围绕三个特定目标设计：目标1-传播最新和重要的 分子免疫学的进步和新范式；目标2 - 创建高度互动，支持和 在许多不同阶段的科学家之间共享科学知识的联合环境 培训和职业发展，从而支持新的合作，扩大专业和 指导网络和职业发展；和目标3-增强个人之间的多样性 参与，为免疫学和生物研究领域的职业发展做出贡献并实现职业发展 更广泛。要求的支持对于使最有前途的培训和初中的人可能至关重要 分子免疫学的教师公开介绍其全体会议的工作，并在小环境中进行互动 与他们的领导者一起。这次会议收到了会议的热情反馈。 先前的会议，为长期延续赋予了强大的任务。