The Molecular Mechanisms of Immune Cell Development and Function

免疫细胞发育和功能的分子机制

• 批准号: 10751580
• 负责人: Amy Susan Weinmann
• 金额: $ 1.15万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-11 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10751580
• 关键词: American; Antigen Receptors; Architecture; Area; Autoimmunity; B-Cell Development; Biological; Biological Models; Biology; California; Canada; Career Mobility; Cells; Characteristics; Clinical; Collaborations; DNA Repair; Development; Developmental Process; Disease; Educational workshop; Effector Cell; Environment; Epigenetic Process; Evaluation; Event; Faculty; Feedback; Financial Support; Fostering; Functional disorder; Funding; Future; Gene Expression; Gene Expression Regulation; Gene Rearrangement; Genes; Genetic Recombination; Genome; Genomic DNA; Genomics; Goals; Health; Hematopoietic; Hematopoietic stem cells; Human; Immune; Immune response; Immune system; Immunologic Receptors; Immunology; Immunooncology; Individual; Innate Immune Response; International; Island; Knowledge; Laboratories; Lymphoid Tissue; Malignant Neoplasms; Mentors; Metabolic; Modeling; Molecular; Molecular Biology; Molecular Immunology; Nova Scotia; Oncology; Pattern; Persons; Postdoctoral Fellow; Process; Receptor Gene; Regulation; Request for Proposals; Research; Research Personnel; Science; Scientist; Senior Scientist; Series; Signal Pathway; Signal Transduction; Societies; System; T cell differentiation; Time; Training; Transcriptional Regulation; Travel; United States National Institutes of Health; Woman; Work; adaptive immune response; biological research; career; career development; design; epigenetic regulation; experience; gene network; genome integrity; genome-wide; graduate student; gut homeostasis; immune function; immunoregulation; insight; intestinal homeostasis; lymphoid organ; meetings; pandemic disease; posters; pre-doctoral; programs; response; scientific atmosphere; stem cells; symposium; synergism; thymocyte; tumor

PROJECT SUMMARY This proposal requests partial support for a 2023 Science Research Conference (SRC) sponsored by the Federation of American Societies for Experimental Biology (FASEB) on the subject of “Molecular Mechanisms of Immune Cell Development and Function”, the 11th conference in this highly successful series. This conference has been chosen for sponsorship by FASEB after a competitive re-evaluation every other year since its inception in summer 2003. The distinctive features of this conference are: (1) A strong emphasis on molecular biology of gene regulation in immune cell development and function, including new insights emerging from genome-wide and systems approaches; (2) Close integration of the study of molecular mechanisms of immune receptor gene recombination and diversification with concepts in genomic architecture and long-range genomic control; (3) Deliberate juxtaposition of research on different classes of immune cells to reveal larger patterns of shared use of molecular and developmental mechanisms; (4) An explicit focus on gene network and signaling network connections rather than “one gene at a time” studies to provide a comprehensive explanation of biological regulation; (5) Creation of sessions that integrate the major molecular/mechanistic themes of the meeting with immuno-oncology, gut homeostasis, and autoimmunity; (6) Integration of presentations from scientists at many career levels, from internationally renowned experts to junior postdoctoral fellows and graduate students, in an intensive, all-plenary program—allowing trainees easy access to experienced senior scientists who in turn gain an appreciation of the young people’s impact on the field, and (7) Implementation of our unique financial model in which invited speakers forego financial support for their participation to allow the use of the majority of funds to support trainees and young investigators who are establishing their independent careers. These distinctive features are designed around three specific aims: Aim 1—To disseminate the most recent and important advances and new paradigms in molecular immunology; Aim 2—To create a highly interactive, supportive, and collegial environment for the sharing of scientific knowledge between scientists at many different stages of training and career development, thereby facilitating new collaborations, broadening of professional and mentoring networks, and career development; and Aim 3—To enhance diversity among the individuals who participate in, contribute to, and achieve career advancement in the field of immunology and biological research more broadly. The support requested is crucial to make it possible for the most promising trainees and junior faculty in molecular immunology to publicly present their work in plenary sessions and interact in a small setting with leaders in their field. This meeting has received enthusiastic feedback from conference attendees of previous meetings, giving it a strong mandate for long-term continuation.

项目总结 该提案要求部分支持2023年科学研究会议(SRC)，该会议由 美国实验生物学学会联合会(FASE B)关于“分子机制”的研究 免疫细胞发育和功能“，这是这个非常成功的系列中的第11次会议。这次会议 自成立以来每隔一年进行一次竞争性重新评估后，被选为FASE B的赞助商 2003年夏天。这次会议的鲜明特点是：(1)高度重视生物分子生物学 免疫细胞发育和功能中的基因调控，包括来自全基因组的新见解 (2)紧密结合免疫受体基因的分子机制研究 基因组结构和远程基因组控制概念的重组和多样化；(3) 故意将对不同类别免疫细胞的研究并列在一起，以揭示共享使用的更大模式 分子和发育机制；(4)明确关注基因网络和信号网络 联系，而不是“一次一个基因”的研究，以提供一个全面的生物学解释 管理；(5)设立会议，将会议的主要分子/机制主题与 免疫肿瘤学、肠道动态平衡和自身免疫；(6)整合了许多 职业水平，从国际知名专家到初级博士后研究员和研究生，在 密集的全会计划-使学员能够轻松接触到经验丰富的资深科学家，这些科学家反过来又能获得 赞赏年轻人对实地的影响，以及(7)实施我们独特的财务模式 其中，受邀发言者放弃了对他们的参与的财政支持，以允许使用大多数资金 以支持正在建立独立职业生涯的实习生和年轻调查人员。这些与众不同的 专题是围绕三个具体目标设计的：目标1-传播最新和最重要的 分子免疫学的进展和新范式；目标2-创建一个高度互动、支持和 为处于不同阶段的科学家分享科学知识创造了一个合伙的环境 培训和职业发展，从而促进新的合作，扩大专业和 辅导网络和职业发展；以及目标3--加强以下个人的多样性 在免疫学和生物研究领域参与、贡献和实现职业发展 更广泛地说。所要求的支持对于使最有前途的实习生和初级学员成为可能至关重要 分子免疫学教授在全体会议上公开介绍他们的工作，并在小范围内进行互动 与各自领域的领先者合作。本次会议得到了与会人员的热烈反馈 过去的几次会议，赋予了它长期延续的强大授权。