Brain Mechanisms Supporting Mindfulness Meditation-Induced Pain and Stress Relief

支持正念冥想引起的疼痛和压力缓解的大脑机制

基本信息

批准号：
10752331
负责人：
Jon Gregory Dean
金额：
$ 6.95万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10752331
关键词：
Absence of pain sensation Affect Affective American Amygdaloid structure Anatomy Anterior Anxiety Anxiety Disorders Area Arousal Attenuated Awareness Behavioral Books Brain Brain region Chronic stress Clinical Clinical Trials Cognitive Computational Technique Data Data Set Development Diagnosis Emotional Ethics Event Exhibits Exposure to Fostering Functional Magnetic Resonance Imaging Health Human Individual Institution Intervention Knowledge Laboratories Machine Learning Meditation Mentors Mentorship Methods Mindfulness Training Neuroanatomy Neurologic Nociception Pain Pain Free Pain intensity Pain management Participant Pattern Perfusion Persons Placebos Procedures Process Prosencephalon Psychophysics Psychophysiology Regulation Research Residual state Scanning Sensory Series Stimulus Stress Structure System Techniques Testing Time Training Training Activity Training Technics Visual Work analog blood oxygen level dependent career career development chronic pain chronic pain patient chronic painful condition cingulate cortex comorbidity cost effective economic impact healthy volunteer imaging study insight interest mindfulness mindfulness meditation negative affect neural neuroimaging neuromechanism novel pain reduction pain relief predictive signature psychologic response skills somatosensory statistics stress disorder stress management stress reduction

项目摘要

Project Summary Stress and chronic pain disorders are comorbid conditions wherein stress exacerbates pain. Mindfulness meditation, a non-opioidergic and self-regulatory technique that trains non-reactive awareness to arising sensory and affective events, reduces clinical and experimentally induced pain and stress. Our recently completed psychophysical and functional magnetic resonance imaging (fMRI) study found that four, 20-minute sessions of mindfulness training in healthy participants reduced stress ( 39%, p = .023) and pain intensity ( 32%, p < .001) in response to noxious heat (49°C). Stress reductions also predicted lower pain intensity (p = .013). The perigenual anterior cingulate cortex (pgACC), a cognitive-affective brain area involved in reappraisal, and the amygdala, a key brain area involved in sensory and emotional processing, are associated with modulating pain and stress and share extensive anatomical connections. Our laboratory has demonstrated that increased pgACC activity underlies mindfulness-induced reductions in pain and anxiety in healthy individuals, while mindfulness-induced deactivation of the amygdala has been shown to correlate with pain and stress relief across separate studies. Despite these findings, no study has determined whether mindfulness meditation promotes stress relief and analgesia by modulating the pgACC and corresponding neural activity in and connectivity between nociceptive and negative affect-specific brain regions. To this end, we will analyze the blood-oxygen-level-dependent fMRI data corresponding to our behavioral findings to test the following hypotheses. We will first determine if higher pgACC (HYP1a) and lower amygdala (HYP1b) activity during mindfulness is associated with higher pain/stress relief. We will next determine if increased pgACC-amygdalar functional connectivity correlates with mindfulness-induced pain (HYP1c) and stress relief (HYP1d). Our preliminary analyses found that mindfulness-induced analgesia correlates with reductions in machine-learned, multivariate fMRI signatures sensitive and specific to nociception (neurologic pain signature; NPS, p = .03) and stimulus-induced negative affect (p = .01). We will similarly determine if reductions in negative affect brain responses correspond to stress relief (HYP2a). Finally, we will confirm if increased NPS- (HYP2b) and negative affect signature- (HYP2c) pgACC connectivity is associated with pain and/or stress relief. The proposed research and training will be accomplished under the mentorship of my Sponsor, Co- sponsors, and Co-Mentor, who are experts in fMRI clinical trials on pain, meditation, and/or stress. Activities include a) training in pain-evoking procedures and statistical and computational techniques, programming, and neuroanatomy for analysis of behavioral and fMRI data b) ethical interactions with individuals with chronic pain and stress, c) scientifically validated mindfulness training, and d) fostering career development strategies. The knowledge and skills gained will prepare me to successfully navigate a career as an independent cognitive neuroscientist identifying the brain mechanisms of novel treatments for pain and comorbid health ailments.

项目摘要压力和慢性疼痛障碍是合并症，压力会加剧疼痛。正念冥想，一种非反对性和自我调节技术，训练无反应的意识感觉和情感事件可减少临床和实验引起的疼痛和压力。我们最近完成的心理物理和功能磁共振成像（fMRI）研究发现四个，20分钟健康参与者的正念训练会减轻压力（39％，p = .023）和疼痛强度（ 32％，p <.001）响应有害热量（49°C）。压力减轻还预测了较低的疼痛强度（P = .013）。阴性前扣带回皮质（PGACC），一种与认知影响的大脑区域重新评估和杏仁核（涉及感觉和情感处理的关键大脑区域）是相关的随着调节疼痛和压力，并具有广泛的解剖联系。我们的实验室有证明PGACC活性增加的基础是正念引起的疼痛和动画减少健康的个体，虽然正念引起的杏仁核的失活已证明与在单独的研究中缓解疼痛和压力。尽管有这些发现，但尚无研究确定是否正念冥想通过调节PGACC并相应地促进压力缓解和镇痛伤害性和负面影响特异性大脑区域之间的神经活动和连通性。为此，我们将分析与我们的行为结果相对应的血氧级依赖性fMRI数据以下假设。我们将首先确定较高的PGACC（HYP1A）和较低的杏仁核（HYP1B）是否正念期间的活动与较高的疼痛/压力缓解有关。接下来，我们将确定是否增加 PGACC-Amygdalar功能连通性与正念引起的疼痛（HYP1C）和压力缓解相关（HYP1D）。我们的初步分析发现，正念诱导的镇痛与减少相关机器学习，多元fMRI签名敏感且对伤害感受（神经系统疼痛特征； NP，p = .03）和刺激诱导的负面影响（p = .01）。我们将同样确定减少负面影响大脑反应对应于压力缓解（HYP2A）。最后，我们将确认是否增加了NPS- （HYP2B）和负面影响签名 - （HYP2C）PGACC连通性与疼痛和/或压力有关宽慰。拟议的研究和培训将在我的赞助商的指导下完成赞助商和Co-Incermor是FMRI临床试验的专家，疼痛，冥想和/或压力。活动包括a）痛苦诱发程序以及统计和计算技术的培训，编程和用于分析行为和fMRI数据的神经解剖学b）与慢性疼痛个体的道德相互作用和压力，c）科学验证的正念培训，d）培养职业发展策略。获得的知识和技能将使我能够成功地涉足独立认知的职业神经科学家确定疼痛和合并健康疾病的新型治疗方法的大脑机制。