Reciprocal brain-lung responses in post-stroke pneumonia

中风后肺炎的脑肺交互反应

基本信息

  • 批准号:
    10754060
  • 负责人:
  • 金额:
    $ 25.13万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-08-01 至 2025-07-31
  • 项目状态:
    未结题

项目摘要

Project Summary Stroke is the leading cause of disability in the United States. Patients with stroke are at increased risk of severe pneumonia and post-stroke pneumonia is associated with poor outcomes. This multi-PI project will leverage the complementary expertise of a Stroke Neurologist/Immunologist and a Pulmonary Critical Care physician/Immunologist to jointly tackle the mechanisms of increased risk of severe pneumonia in stroke patients and the mechanisms of dysregulated neuroinflammation and neurological recovery after stroke. Preliminary work in our experimental model of ischemic stroke and Klebsiella pneumonia demonstrates that bacterial inoculation into the lungs leads to reduced neutrophil recruitment and increased bacterial dissemination after stroke. Furthermore, pneumonia leads to enhanced neuroinflammation and increased interferon responses in the microglia and endothelial cells after stroke. The primary hypothesis is that stroke leads to an impairment in neutrophil function allowing for bacterial escape and dissemination through the body, which in turn leads to a delay in the resolution of neuroinflammation in the brain and further brain injury. The overall goal of the proposal is to identify new treatment targets to reduce post-stroke pneumonia and improve outcomes after stroke.
项目摘要 中风是美国残疾的主要原因。中风患者的风险增加, 严重肺炎和中风后肺炎与不良结局相关。这个多PI项目将 利用中风神经学家/免疫学家和肺重症监护专家的互补专业知识 医生/免疫学家共同解决中风中严重肺炎风险增加的机制 卒中后神经炎症失调和神经功能恢复的机制。 我们在缺血性中风和克雷伯氏肺炎实验模型中的初步工作表明, 细菌接种到肺中导致中性粒细胞募集减少和细菌增加。 中风后的传播此外,肺炎导致神经炎症增强, 脑卒中后小胶质细胞和内皮细胞的干扰素反应主要假设是中风 导致中性粒细胞功能受损,从而允许细菌逃逸并通过身体传播, 这又导致脑中神经炎症消退的延迟和进一步的脑损伤。的 该提案的总体目标是确定新的治疗目标,以减少卒中后肺炎, 中风后的结果

项目成果

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Charles S Dela Cruz其他文献

Charles S Dela Cruz的其他文献

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{{ truncateString('Charles S Dela Cruz', 18)}}的其他基金

Viral and immune-mediated CNS pathology during SARS-CoV-2 infection
SARS-CoV-2 感染期间病毒和免疫介导的中枢神经系统病理学
  • 批准号:
    10554829
  • 财政年份:
    2020
  • 资助金额:
    $ 25.13万
  • 项目类别:
MAVS-Mediated Pulmonary Inflammation and Injury Response During Cigarette Smoke Exposure and Influenza Viral Infection and in COPD
香烟烟雾暴露和流感病毒感染以及 COPD 期间 MAVS 介导的肺部炎症和损伤反应
  • 批准号:
    9780742
  • 财政年份:
    2019
  • 资助金额:
    $ 25.13万
  • 项目类别:
MAVS-Mediated Pulmonary Inflammation and Injury Response During Cigarette Smoke Exposure and Influenza Viral Infection and in COPD
香烟烟雾暴露和流感病毒感染以及 COPD 期间 MAVS 介导的肺部炎症和损伤反应
  • 批准号:
    10292925
  • 财政年份:
    2019
  • 资助金额:
    $ 25.13万
  • 项目类别:
MAVS-Mediated Pulmonary Inflammation and Injury Response During Cigarette Smoke Exposure and Influenza Viral Infection and in COPD
香烟烟雾暴露和流感病毒感染以及 COPD 期间 MAVS 介导的肺部炎症和损伤反应
  • 批准号:
    10045508
  • 财政年份:
    2019
  • 资助金额:
    $ 25.13万
  • 项目类别:
MAVS-Mediated Pulmonary Inflammation and Injury Response During Cigarette Smoke Exposure and Influenza Viral Infection and in COPD
香烟烟雾暴露和流感病毒感染以及 COPD 期间 MAVS 介导的肺部炎症和损伤反应
  • 批准号:
    10515290
  • 财政年份:
    2019
  • 资助金额:
    $ 25.13万
  • 项目类别:
Host-Pneumococcal Interaction in the Lung
肺部宿主与肺炎球菌的相互作用
  • 批准号:
    8966696
  • 财政年份:
    2014
  • 资助金额:
    $ 25.13万
  • 项目类别:
Molecular and Cellular Interactions Between Cigarette Smoke Exposure and RSV
香烟烟雾暴露与 RSV 之间的分子和细胞相互作用
  • 批准号:
    7953132
  • 财政年份:
    2010
  • 资助金额:
    $ 25.13万
  • 项目类别:
Molecular and Cellular Interactions Between Cigarette Smoke Exposure and RSV
香烟烟雾暴露与 RSV 之间的分子和细胞相互作用
  • 批准号:
    8668779
  • 财政年份:
    2010
  • 资助金额:
    $ 25.13万
  • 项目类别:
Molecular and Cellular Interactions Between Cigarette Smoke Exposure and RSV
香烟烟雾暴露与 RSV 之间的分子和细胞相互作用
  • 批准号:
    8277248
  • 财政年份:
    2010
  • 资助金额:
    $ 25.13万
  • 项目类别:
Molecular and Cellular Interactions Between Cigarette Smoke Exposure and RSV
香烟烟雾暴露与 RSV 之间的分子和细胞相互作用
  • 批准号:
    8470223
  • 财政年份:
    2010
  • 资助金额:
    $ 25.13万
  • 项目类别:

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Impact of Aging on Oxysterol Regulation of Alveolar Macrophage Function during S. pneumoniae
衰老对肺炎链球菌期间肺泡巨噬细胞功能的氧甾醇调节的影响
  • 批准号:
    10737015
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    2023
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ZIP8 依赖性锌代谢调节肺泡祖细胞衰老和纤维化
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  • 财政年份:
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ZIP8-dependent Zinc Metabolic Regulation in Alveolar Progenitor Cell Aging and Fibrosis
ZIP8 依赖性锌代谢调节肺泡祖细胞衰老和纤维化
  • 批准号:
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  • 财政年份:
    2022
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骨骼衰老和牙周炎中牙槽骨髓 MSC 衰老的调节
  • 批准号:
    10186006
  • 财政年份:
    2021
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Regulation of Alveolar Bone Marrow MSC Senescence in Skeletal Aging and Periodontitis
骨骼衰老和牙周炎中牙槽骨髓 MSC 衰老的调节
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  • 财政年份:
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衰老肺的免疫生物学和肺泡生理学
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The changes in the collagen fiber orientation by aging: an approach to the mechanism of repture of alveolar wall
衰老引起的胶原纤维取向的变化:肺泡壁破裂机制的探讨
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