2023 Angiogenesis Gordon Research Conference and Seminar

项目摘要/摘要 这场血管生成戈登研究会议(GRC)的主题是 发展、疾病和工程组织“，以及随之而来的戈登研究研讨会(GRS， 由受训者组织，并为受训者组织)“利用发育的血管生成来指导细胞治疗和 再生医学“旨在解决血液的巨大异质性的潜在假说 血管由独特的分子和细胞机制构成，确保其适当的形成和稳定。 更好地了解不同器官、大小和形态的血管是如何以及为什么生长和 尽管受到无情的血流动力学攻击，但保持其架构是至关重要的 工程化或再生组织的血管化以及使血管畸形正常化。 因此，会议的目标是弥合现有的知识和交流差距。 在各级研究人员(学生、博士后、学术界和工业界的初级和高级科学家)之间 研究血管生成和血管稳定性，以及专注于血管疾病、干细胞生物学和疾病的研究- 相关的血管功能障碍，包括癌症、心血管疾病和中风。这些字段具有 最近开发的范例、工具和模型有助于实现这一目标，而且这种集成预计将 科学朝着及时转化基本发现的方向前进。免费的GRS会前会议还将 将被纳入，并将由受训人员和受训人员组织。GRS将以实习生工作演示为特色 以促进联网，并在他们过渡到主会议时为他们提供同级组。 GRC主席和副主席是该领域的两名女科学家，拥有良好的科学记录 以及在组织国际科学会议方面的丰富经验。会议的目标将是 通过在Salve Regina召集一组精选的研究人员(约180名参与者)来完成 罗德岛州纽波特大学，2023年7月30日至8月3日，为期一周。这个地点的选择是基于 关于坚实的先例，因为这次会议自1995年以来每两年举行一次，事实证明这是一个理想的环境 为血管生成GRC。会议地点和结构旨在促进广泛的讨论。 回应大部分未公布数据的陈述，并通过以下方式促进非正式联系 分享晚餐和下午的社交活动。被邀请的演讲者是根据研究方面的卓越表现挑选出来的， 话题，以及与受训者接触的意愿。参赛者将被特别挑选，以反映广泛的 在该领域工作的科学家的人口统计数据。目前，女性占已确认发言者的53%， 讨论领袖。总体而言，GRC/GRS将促进持久的跨学科互动和协作 在NIH资助的和国际血管和干细胞生物学家之间，学术界和工业界之间 科学家，并将在这些领域的交叉点培养下一批科学家。这款车的设计 会议将产生持久的影响，因为它解决了血管生成研究中的健康和疾病方面的关键问题。

Project Summary/Abstract This Angiogenesis Gordon Research Conference (GRC), “Angiogenesis and angiostability in development, disease and engineered tissues”, and the accompanying Gordon Research Seminar (GRS, organized by and for trainees) “Harnessing developmental angiogenesis to instruct cell therapies and regenerative medicine” are designed to address the underlying hypothesis that the vast heterogeneity of blood vessels is underlain by unique molecular and cellular mechanisms ensuring their proper formation and stability. A better understanding of how and why blood vessels of different organs, sizes, and morphologies grow and maintain their architecture, despite being under unrelenting hemodynamic assault, is critical to inform vascularization of engineered or regenerating tissues and to normalizing vascular malformations. The goals of the conference are, therefore, to bridge existing knowledge and communication gaps between researchers at all levels (students, postdocs, junior and senior scientists in academia and industry) who study angiogenesis and angiostability and those focusing on vascular diseases, stem cell biology and disease- associated vascular dysfunction, including cancer, cardiovascular diseases, and stroke. These fields have recently developed paradigms, tools, and models to aid this goal, and this integration is predicted to move science forward toward the timely translation of basic discoveries. A complimentary GRS pre-meeting will also be included and will be organized by trainees and for trainees. The GRS will feature trainee work presentations to facilitate networking, and provide them with a peer group as they transition into the main meeting. The GRC Chair and Vice-Chair are two female scientists in the field with strong scientific track records and substantial experience in the organization of international scientific meetings. The meeting goals will be accomplished by bringing together a selected group of researchers (about 180 participants) at Salve Regina University, Newport, Rhode Island, for a week from July 30 to August 3rd, 2023. The choice of this venue is based on solid precedent, as this meeting has taken place every two years since 1995 and has proven an ideal setting for the Angiogenesis GRC. The venue and meeting structure are designed to foster extensive discussion in response to presentations of largely unpublished data and to promote informal networking through shared meals and afternoon social activities. Invited speakers are chosen based on excellence in research, topic, and willingness to engage trainees. Participants will specifically be selected to reflect the broad demographics of scientists working in the field. Women currently comprise 53% of confirmed speakers and discussion leaders. Overall, this GRC/GRS will foster lasting interdisciplinary interactions and collaborations amongst NIH-funded and international vascular and stem cell biologists, between academic and industry scientists, and will develop the next cadre of scientists at the intersection of these fields. The design of the meeting will have a lasting impact as it tackles crucial questions in health and disease in angiogenesis research.