2023 Angiogenesis Gordon Research Conference and Seminar

2023年血管生成戈登研究会议暨研讨会

• 批准号: 10753606
• 负责人: Ondine B Cleaver
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-27 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10753606
• 关键词: Academia; Address; Affect; Aging; Architecture; Awareness; Basic Science; Big Data; Biological Markers; Biology; Biomechanics; Blood Vessels; Cardiovascular Diseases; Cell Therapy; Cells; Chronic; Collaborations; Communication; Cues; Data; Development; Dimensions; Disease; Disease Progression; Endothelial Cells; Endothelium; Ensure; Environment; Exposure to; Female; Fostering; Funding; Future; Gatekeeping; Generations; Genetic Engineering; Goals; Growth; Health; Heterogeneity; Human; Image; Industry; International; Knowledge; Learning; Life; Maintenance; Malignant Neoplasms; Medicine; Microfluidics; Modality; Modeling; Molecular; Molecular Analysis; Morphology; Natural regeneration; Ointments; Organ; Organoids; Participant; Peer Group; Physiological; Postdoctoral Fellow; Pre-Clinical Model; Records; Regenerative Medicine; Research; Research Personnel; Rhode Island; Running; Schedule; Science; Scientist; Senior Scientist; Signal Pathway; Signaling Molecule; Solid; Source; Stimulus; Stroke; Structure; Students; System; Systems Biology; Technology; Therapeutic; Tissue Engineering; Tissues; Translating; Translations; United States National Institutes of Health; Universities; Vascular Diseases; Vocational Guidance; Woman; Work; angiogenesis; assault; bench to bedside; combat; data exchange; demographics; design; diagnostic tool; driving force; expectation; experience; genome-wide; graduate student; hemodynamics; international scientific organization; malformation; meetings; new technology; next generation; non-genetic; novel; organ regeneration; personalized medicine; pre-doctoral; regenerative tissue; response; single cell sequencing; single cell technology; social; stem cell biology; stem cells; success; symposium; targeted treatment; technology development; tissue regeneration; tool; transcriptomics; translational approach; vascular tissue engineering; willingness

Project Summary/Abstract This Angiogenesis Gordon Research Conference (GRC), “Angiogenesis and angiostability in development, disease and engineered tissues”, and the accompanying Gordon Research Seminar (GRS, organized by and for trainees) “Harnessing developmental angiogenesis to instruct cell therapies and regenerative medicine” are designed to address the underlying hypothesis that the vast heterogeneity of blood vessels is underlain by unique molecular and cellular mechanisms ensuring their proper formation and stability. A better understanding of how and why blood vessels of different organs, sizes, and morphologies grow and maintain their architecture, despite being under unrelenting hemodynamic assault, is critical to inform vascularization of engineered or regenerating tissues and to normalizing vascular malformations. The goals of the conference are, therefore, to bridge existing knowledge and communication gaps between researchers at all levels (students, postdocs, junior and senior scientists in academia and industry) who study angiogenesis and angiostability and those focusing on vascular diseases, stem cell biology and disease- associated vascular dysfunction, including cancer, cardiovascular diseases, and stroke. These fields have recently developed paradigms, tools, and models to aid this goal, and this integration is predicted to move science forward toward the timely translation of basic discoveries. A complimentary GRS pre-meeting will also be included and will be organized by trainees and for trainees. The GRS will feature trainee work presentations to facilitate networking, and provide them with a peer group as they transition into the main meeting. The GRC Chair and Vice-Chair are two female scientists in the field with strong scientific track records and substantial experience in the organization of international scientific meetings. The meeting goals will be accomplished by bringing together a selected group of researchers (about 180 participants) at Salve Regina University, Newport, Rhode Island, for a week from July 30 to August 3rd, 2023. The choice of this venue is based on solid precedent, as this meeting has taken place every two years since 1995 and has proven an ideal setting for the Angiogenesis GRC. The venue and meeting structure are designed to foster extensive discussion in response to presentations of largely unpublished data and to promote informal networking through shared meals and afternoon social activities. Invited speakers are chosen based on excellence in research, topic, and willingness to engage trainees. Participants will specifically be selected to reflect the broad demographics of scientists working in the field. Women currently comprise 53% of confirmed speakers and discussion leaders. Overall, this GRC/GRS will foster lasting interdisciplinary interactions and collaborations amongst NIH-funded and international vascular and stem cell biologists, between academic and industry scientists, and will develop the next cadre of scientists at the intersection of these fields. The design of the meeting will have a lasting impact as it tackles crucial questions in health and disease in angiogenesis research.

项目概要/摘要 本次血管生成戈登研究会议 (GRC)，“血管生成和血管稳定性 发育、疾病和工程组织”，以及随附的戈登研究研讨会（GRS， 由学员组织并为学员组织）“利用发育性血管生成来指导细胞疗法和 “再生医学”旨在解决以下基本假设：血液的巨大异质性 血管由独特的分子和细胞机制支撑，确保其正确形成和稳定性。 更好地了解不同器官、大小和形态的血管如何以及为何生长和 尽管受到无情的血流动力学攻击，但保持其结构对于告知信息至关重要 工程或再生组织的血管化以及使血管畸形正常化。 因此，会议的目标是弥合现有的知识和沟通差距 各级研究人员（学术界和工业界的学生、博士后、初级和高级科学家）之间 研究血管生成和血管稳定性以及那些专注于血管疾病、干细胞生物学和疾病的研究 相关的血管功能障碍，包括癌症、心血管疾病和中风。这些字段有 最近开发的范式、工具和模型来帮助实现这一目标，并且这种集成预计将进一步发展 科学朝着及时转化基本发现的方向前进。免费的 GRS 会前会议还将 包括在内，并将由受训者和为受训者组织。 GRS 将以实习生工作演示为特色 促进交流，并在他们过渡到主要会议时为他们提供一个同行小组。 GRC 主席和副主席是两位在该领域拥有良好科学记录的女性科学家 并在组织国际科学会议方面拥有丰富的经验。会议目标将是 通过将 Salve Regina 的一组选定的研究人员（约 180 名参与者）聚集在一起来完成 罗德岛州纽波特大学，2023 年 7 月 30 日至 8 月 3 日为期一周。此地点的选择基于 具有坚实的先例，因为自 1995 年以来，该会议每两年举行一次，并已证明是一个理想的场所 用于血管生成 GRC。场地和会议结构旨在促进广泛讨论 回应大部分未发表的数据的介绍，并通​​过 共享膳食和下午的社交活动。受邀演讲者的选择基于卓越的研究， 主题以及参与学员的意愿。将专门选择参与者以反映广泛的 在该领域工作的科学家的人口统计。目前，已确认演讲者中女性占 53%， 讨论领袖。总体而言，该 GRC/GRS 将促进持久的跨学科互动与合作 在 NIH 资助的国际血管和干细胞生物学家之间，在学术界和工业界之间 科学家，并将在这些领域的交叉领域培养下一代科学家骨干。的设计 会议将产生持久影响，因为它解决了血管生成研究中健康和疾病的关键问题。