Inhaled Aerosol Dosimetry: Advances, Applications, and Impacts on Risk Assessments and Therapeutics

项目总结/摘要 COVID-19大流行暴露了我们对传染性病毒因子的空气传播缺乏了解。 缺乏对气溶胶在体内的沉积、代谢、分布和损伤机制的了解 （悬浮在气体中的颗粒）限制了人们对制定空气质量标准和开发新的吸入式空气净化器的信心。 治疗学递送的吸入剂量（例如，mg/靶组织）由于个体差异， 气溶胶的复杂性和吸入后的内部事件。加州大学欧文分校的空气污染健康影响实验室 自1974年在医学院成立以来，一直致力于这一领域的基础和应用研究。本组织着手开展了一些 几个主题为重点的多学科会议吸入气溶胶。该提案要求支持一项 国际会议“吸入气溶胶剂量测定：进展，应用和影响的风险评估和 治疗学”，将在加州大学欧文分校附近的阿诺德和美宝贝克曼中心举行的国家 科学与工程学院，在欧文，加利福尼亚州3天在2024年10月。会议中心提供坚实的 支持，包括有利于合议，包容和创造性思维的氛围。会议将带来 科学家、工程师、医学研究人员、监管人员和其他通常参加不同专业课程的人一起参加， 会议，并在相对孤立的情况下阅读专业期刊，从而抑制了跨学科的交流， 合作。我们的组织委员会由10名男性和7名女性科学家组成，代表大学，政府和 私人实验室他们意识到医学、科学、政府以及性别方面的关键研究需求 种族不平等。会议包括;概述，最近的研究，复杂的混合物;体外方法，以减少 使用活体动物;计算机模型的进步;和案例研究。每一次会议都是全体会议，目的是让人们理解， 所有的参与者，每个人都有讨论时间。该计划支持跨学科的沟通和协作。 注册费将包括所有会议，以及附近机场（SNA），酒店和酒店之间的交通费用。 会议中心工作人员将帮助有特殊需要的人，并努力吸引来自 代表性不足的群体。学生们将与未来的雇主共进午餐，并将为 优秀学生海报将出版《会议录》，并计划为符合条件的论文发行期刊。 同行审查标准。启动支持由我们的大学提供。总预算约为15.5万美元，2.5万美元是 NHLBI要求帮助支持工作人员和学生，并吸引代表性不足的群体的与会者。 2022年11月26日修订

PROJECT SUMMARY/ABSTRACT The COVID-19 pandemic exposed a critical lack of our understanding the airborne transmission of infectious viral agents. Deficiencies in understanding the deposition, metabolism, distribution in the body, and mechanisms of injury of aerosols (particles suspended in a gas) limit the confidence in setting air quality standards and developing new inhaled therapeutics. The delivered inhaled dose (e.g., mg/target tissues) is poorly understood due to individual differences, the complexity of aerosols, and post inhalation internal events. UC Irvine’s Air Pollution Health Effects Laboratory has been involved in basic and applied research in this area since its founding in the School of Medicine in 1974. It has initiated several topic-focused multi-disciplinary conferences on inhaled aerosols. This proposal requests support for an international conference “Inhaled Aerosol Dosimetry: Advances, Applications and Impacts on Risk Assessments and Therapeutics”, to be held adjacent to the UC Irvine campus at the Arnold and Mabel Beckman Center of the National Academies of Sciences and Engineering, in Irvine, CA 3 days in October of 2024. The conference center offers solid support including an atmosphere conducive to collegiality, inclusion, and creative thinking. The conference will bring together scientists, engineers, medical researchers, regulators, and others who normally attend separate professional meetings, and read specialty journals in relative isolation thereby inhibiting cross-discipline communications and collaborations. Our Organizing Committee of 10 men and 7 women scientists represents universities, governments, and private laboratories. They are aware of critical research needs in medicine, science, and government, as well as gender and racial inequalities. Sessions include; overviews, recent research, complex mixtures; in-vitro methods to reduce the use of live animals; computer model advances; and case studies. Each session is plenary, geared to be understandable by all attendees, and each has discussion time. The program supports cross-discipline communication and collaboration. The registration fee will cover all sessions, and transportation between the nearby airport (SNA), the hotels, and the conference center. Staff will help those with special needs and efforts will be made to attract those from underrepresented groups. Students will have a luncheon with prospective employers, and awards will be made for outstanding student posters. A Proceedings will be published, and a journal issue is planned for those papers that meet peer review standards. Startup support is provided by our University. The total budget is about $155,000, and $25,000 is requested from the NHLBI to help support staff and students, and attract attendees from underrepresented groups. Revised 11-26-2022