Mount Sinai Institutes for Clinical and Translational Sciences

西奈山临床和转化科学研究所

• 批准号: 7892499
• 负责人: Hugh A Sampson
• 金额: $ 3.65万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-14 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7892499
• 关键词: Basic Science; Caregivers; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Clinical Trials Design; Collaborations; Communities; Complex; Consultations; Country; Dentistry; Dentists; Development; Discipline of Nursing; Doctor of Philosophy; Education; Engineering; Environment; Ethical Issues; Faculty; Fostering; Funding; Future; General Population; Goals; Grant; Health Benefit; Health Professional; Health Services Research; Healthcare; Home environment; Hospitals; Information Networks; Institutes; Institution; Interdisciplinary Study; Laboratories; Master of Public Health; Master of Science; Medical; Medicine; Mentors; Methodology; Modeling; Nurses; Participant; Patient Care; Patients; Pharmacists; Pharmacy facility; Physicians; Postdoctoral Fellow; Principal Investigator; Procedures; Professional Education; Recruitment Activity; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Research Training; Resources; Rewards; SECTM1 gene; Scientific Advances and Accomplishments; Scientist; Social Work; Social Workers; Strategic Planning; Structure; Technology; Therapeutic; Training; Training Support; Training and Education; Translating; Translational Research; Translations; United States National Institutes of Health; bench to bedside; career; career development; clinical practice; graduate student; improved; innovation; interdisciplinary collaboration; interest; medical schools; multidisciplinary; novel; programs; standard of care; trend

Despite great scientific advances over the past decade, the translation of these discoveries to the benefit of patients has been hampered by a number of traditional barriers. The overall goal of the Mount Sinai Institutes of Clinical & Translational Sciences is to establish a new research paradigm at Mount Sinai, which will create an integrated multidisciplinary environment that will enable translation of cutting-edge research more quickly and easily from "bench-to-bedside-to-implementation" in the community; train and create an "academic home" for the clinical and translational investigators of tomorrow; and supply the governance, facilities, resources and opportunities needed to elevate the clinical research enterprise so that clinical investigators can take full advantage of Mount Sinai's Translational Research Institutes and potential collaborators in Mount Sinai Hospital and its affiliates, the School of Medicine and partnering institutions, and other CTSA programs around the country. This transformation will be achieved by fulfilling the following Specific Aims: (1) redesign the institutional research enterprise infrastructure and governance by integrating research functions across administrative, departmental and intellectual boundaries, enhancing and promoting interactions between basic scientists and clinical investigators, and streamlining administrative procedures to facilitate the start-up of clinical trials and the dissemination of results; (2) establish a Translational Discoveries Program to facilitate and expedite clinical research by providing consultation, oversight and facilities for clinical and translational research, engaging the surrounding community and our affiliates to rapidly translate health benefits to the general population, and developing new methodologies to improve clinical trial design and reduce participant burden; (3) train and support the translational investigators of tomorrow by overseeing a multi-disciplinary, doctoral degree-granting program in clinical and translational research for all health care professionals, developing a program to recruit, enhance career development and retain clinical and translational researchers, providing an academic home where new collaborations can be formulated; (4) establish an Experimental Therapeutics& Technologies Program to stimulate the development of new methodologies in clinical and translational research by developing an institution-wide mentored program to identify and develop novel clinical and translational research projects; and (5) establish an institution-wide biomedical information infrastructure that can connect basic researchers, clinical researchers, caregivers and laboratories with an integrated network of information. RELEVANCE (See irtstructions): The establishment of the Mount Sinai Institutes of Clinical & Translational Sciences would create an effective, efficient and centralized research administrative structure, foster and reward interdisciplinary collaborations, educate and retain the clinical and translational investigators of the future, enable translation of basic scientific discoveries into clinical practice, and deliver to our diverse community new therapies and a standard of care that would have been unimaginable even five years ago.

尽管在过去十年中取得了巨大的科学进步，但将这些发现转化为有益于人类的 患者受到一些传统障碍的阻碍。西奈山的总体目标 临床与转化科学研究所将在西奈山建立一个新的研究范式， 这将创造一个综合的多学科环境，使翻译的尖端 在社区中更快、更容易地从“实验室到床边再到实施”进行研究;培训和 为未来的临床和翻译研究人员创建一个“学术之家”;并提供 提升临床研究企业所需的治理、设施、资源和机会， 临床研究人员可以充分利用西奈山的转化研究所和潜力， 西奈山医院及其附属机构，医学院和合作机构的合作者，以及 全国各地的CTSA项目这一转变将通过实现以下目标来实现 具体目标：（1）通过整合，重新设计机构研究企业的基础设施和治理结构 跨越行政、部门和知识界限的研究职能， 促进基础科学家和临床研究者之间的互动， （2）制订一套程序，以方便临床试验的展开和结果的公布; 转化发现计划通过提供咨询， 监督和设施的临床和转化研究，参与周围的社区和我们的 附属机构迅速将健康惠益转化为普通民众，并开发新的方法， 改进临床试验设计并减轻参与者负担;（3）培训和支持翻译人员 未来的研究人员通过监督多学科，博士学位授予计划，在临床和 所有医疗保健专业人员的转化研究，制定一项计划，以招募，提高职业生涯 发展和留住临床和翻译研究人员，提供一个学术家园， 可以制定合作;（4）建立实验治疗和技术计划， 通过开发一种新的临床和转化研究方法， 机构范围内的指导计划，以确定和开发新的临床和转化研究项目; 以及（5）建立一个机构范围的生物医学信息基础设施，可以连接基础研究人员， 临床研究人员、护理人员和实验室拥有一个综合信息网络。 相关性（见说明）： 西奈山临床与转化科学研究所的成立将创造一个 有效、高效和集中的研究行政结构，促进和奖励跨学科 合作，教育和留住未来的临床和翻译研究者， 将基础科学发现转化为临床实践，并为我们多样化的社区提供新的疗法和 这在五年前是不可想象的。