Administrative Core
行政核心
基本信息
- 批准号:8848939
- 负责人:
- 金额:$ 1.62万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-03-01 至 2015-02-28
- 项目状态:已结题
- 来源:
- 关键词:3 year old6 year oldAccountingAdultAdvisory CommitteesAffectAllergicAllergic DiseaseAllergic rhinitisAllergy to peanutsAmericanAsthmaAtopic DermatitisBirth RateCattleChildClinicalCommunicationConsultationsCountryDatabasesDeveloped CountriesDiseaseEquipmentFoodFood HypersensitivityFutureGoalsHuman ResourcesHypersensitivityIgEImmunologicsImmunotherapyInfantLifeMeasuresMediatingMethodsMilkMilk HypersensitivityMonitorNational Institute of Allergy and Infectious DiseaseNutsProceduresProcessReportingResearchResearch DesignResourcesReview CommitteeSeafoodServicesTeleconferencesTherapeuticTravelTreesUnited States National Center for Health StatisticsVertebral columnWorkbasedata sharingexperienceimmunopathologymeetingsmemberpreventprophylactic
项目摘要
Food allergy affects over 11 million Americans and is most prevalent in young children, with 6% - 8% of
children less than 3 years of age experiencing some form of food hypersensitivty. Milk allergy is the most
common cause of food hypersensitivity in infants and young children, typically develops in the first year of
life, affects 2.5% of infants in industrialized countries, and is "outgrown" in about 80% of children by 6 years
of age. IgE-mediated allergy accounts for about 70% of milk allergic disorders, i.e. 1.8% of young infants,
and often is a harbinger of future atopic disorders and other food allergies. Despite an increased
understanding of IgE-mediated immunopathology, no successful therapeutic measures have been
developed to prevent or reverse food allergies. The overall goal of this Center is to elucidate further
underlying immunologic mechanisms of milk allergy and to develop safe and effective forms of therapy.
The Administrative Core will facilitate this effort by providing the organizational backbone for this Center,
monitoring clincal trials, providing biostatistical support for all projects, and coordinating interactions within
and outside the Center, e.g. NIAID, other AADCR Centers and the external Scientific Review Committee.
This wll be achieved through the following Specific Aims:
Aim #1: Facilitate communication and interaction between Projects 1-3, assist in subject recruitment and
retention, and provide clinical monitoring, database support and biostatistical support for all projects.
Aim #2: Implement an external Scientific Review Committee with independent experts in the field of food
allergy and immunotherapy.
Aim #3: Provide mechanisms for communicating with other members of the AADCR Centers.
Aim #4: Oversee resource and data sharing between this project and other members of the AADCR Centers.
The Administrative Core will provide manegerial support, organizational support for monthly internal
project review meetings, quarterly inter-project meetings of Pi's and key personnel, quarterly AADCRC
Steering Committee teleconferences, bienniel Scientific Advisory Committee teleconferences, and annual
AADCRC PI meetings in Bethesda. The Core will arrange lodging [if nececessary; e.g. external reviewers],
meeting rooms and equipment for meetings held at Mount Sinai, and process travel expense reports for
reimbursement to scientific and PI annual meetings. The Core will also work with the AADCRC Steering
Committee to promote the sharing of data collected as a part of this proposal and of methods, procedures
and resources developed in support of this proposal with other members of the AADCRC network.
食物过敏影响了1100多万美国人,在幼儿中最为普遍,其中6% - 8%的人患有食物过敏
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Hugh A Sampson其他文献
Standardization of anti-asthma herbal formula MSSM-002 by HPLC chromatographic fingerprint
- DOI:
10.1016/s0091-6749(02)81886-3 - 发表时间:
2002-01-01 - 期刊:
- 影响因子:
- 作者:
Zhong-Mei Zou;Hugh A Sampson;Xiu-Min Li - 通讯作者:
Xiu-Min Li
The Chinese herbal formula, MSSM-002, can reverse the established Th2 phenotype, which is accompanied with down regulation of the th2 transcription factor GATA-3
- DOI:
10.1016/s0091-6749(02)81592-5 - 发表时间:
2002-01-01 - 期刊:
- 影响因子:
- 作者:
Xiu-Min Li;Ariel Teper;Zhong-Mei Zou;Kamal D Srivastava;Brian H Schofield;Hugh A Sampson - 通讯作者:
Hugh A Sampson
Detection of milk proteins in dry powder inhalers containing lactose
- DOI:
10.1016/s0091-6749(02)81924-8 - 发表时间:
2002-01-01 - 期刊:
- 影响因子:
- 作者:
Anna H Nowak-Wegrzyn;Ludmilla Bardina;Kirsten Beyer;Wayne G Shreffler;Hugh A Sampson - 通讯作者:
Hugh A Sampson
Effects of preparation methods on the allergenicity of peanut in a murine model of peanut-induced anaphylaxis
- DOI:
10.1016/s0091-6749(02)81676-1 - 发表时间:
2002-01-01 - 期刊:
- 影响因子:
- 作者:
Hayf Emeil Al-Mussawir;Kamal D Srivastava;Kirsten Beyer;Jin-Hua Li;Side Li;Wesley Burks;Gary A Bannon;Xiu-Min Li;Hugh A Sampson - 通讯作者:
Hugh A Sampson
Timing of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study
重复肾上腺素给药时间以告知儿科过敏反应观察期:一项回顾性队列研究
- DOI:
10.1016/s2352-4642(25)00139-7 - 发表时间:
2025-07-01 - 期刊:
- 影响因子:15.500
- 作者:
Timothy E Dribin;Hugh A Sampson;Yin Zhang;Stephanie Boyd;Nanhua Zhang;Kenneth A Michelson;Mark I Neuman;David C Brousseau;Rakesh D Mistry;Stephen B Freedman;Paul L Aronson;Kelly R Bergmann;Brittany Boswell;Sri S Chinta;Wee-Jhong Chua;Ari R Cohen;Joanna S Cohen;Alicia Daggett;Justin R Davis;Julia F Freeman;Seth Woolf - 通讯作者:
Seth Woolf
Hugh A Sampson的其他文献
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{{ truncateString('Hugh A Sampson', 18)}}的其他基金
MOUNT SINAI INSTITUTES FOR CLINICAL AND TRANSLATIONAL SCIENCES
西奈山临床和转化科学研究所
- 批准号:
8364989 - 财政年份:2011
- 资助金额:
$ 1.62万 - 项目类别:
Immunologic Responses to Cow's Milk Proteins in IgE-mediated Cow's Milk Allergy
IgE 介导的牛奶过敏中牛奶蛋白的免疫反应
- 批准号:
8034293 - 财政年份:2010
- 资助金额:
$ 1.62万 - 项目类别:
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