Administrative Core

行政核心

基本信息

  • 批准号:
    8848939
  • 负责人:
  • 金额:
    $ 1.62万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-03-01 至 2015-02-28
  • 项目状态:
    已结题

项目摘要

Food allergy affects over 11 million Americans and is most prevalent in young children, with 6% - 8% of children less than 3 years of age experiencing some form of food hypersensitivty. Milk allergy is the most common cause of food hypersensitivity in infants and young children, typically develops in the first year of life, affects 2.5% of infants in industrialized countries, and is "outgrown" in about 80% of children by 6 years of age. IgE-mediated allergy accounts for about 70% of milk allergic disorders, i.e. 1.8% of young infants, and often is a harbinger of future atopic disorders and other food allergies. Despite an increased understanding of IgE-mediated immunopathology, no successful therapeutic measures have been developed to prevent or reverse food allergies. The overall goal of this Center is to elucidate further underlying immunologic mechanisms of milk allergy and to develop safe and effective forms of therapy. The Administrative Core will facilitate this effort by providing the organizational backbone for this Center, monitoring clincal trials, providing biostatistical support for all projects, and coordinating interactions within and outside the Center, e.g. NIAID, other AADCR Centers and the external Scientific Review Committee. This wll be achieved through the following Specific Aims: Aim #1: Facilitate communication and interaction between Projects 1-3, assist in subject recruitment and retention, and provide clinical monitoring, database support and biostatistical support for all projects. Aim #2: Implement an external Scientific Review Committee with independent experts in the field of food allergy and immunotherapy. Aim #3: Provide mechanisms for communicating with other members of the AADCR Centers. Aim #4: Oversee resource and data sharing between this project and other members of the AADCR Centers. The Administrative Core will provide manegerial support, organizational support for monthly internal project review meetings, quarterly inter-project meetings of Pi's and key personnel, quarterly AADCRC Steering Committee teleconferences, bienniel Scientific Advisory Committee teleconferences, and annual AADCRC PI meetings in Bethesda. The Core will arrange lodging [if nececessary; e.g. external reviewers], meeting rooms and equipment for meetings held at Mount Sinai, and process travel expense reports for reimbursement to scientific and PI annual meetings. The Core will also work with the AADCRC Steering Committee to promote the sharing of data collected as a part of this proposal and of methods, procedures and resources developed in support of this proposal with other members of the AADCRC network.
食物过敏影响超过1100万美国人,在幼儿中最普遍, 3岁以下的儿童经历某种形式的食物过敏。牛奶过敏是最 婴儿和幼儿食物过敏的常见原因,通常发生在第一年, 在工业化国家,2.5%的婴儿在生命中受到影响,大约80%的儿童在6岁时“长大” 年龄。IgE介导的变态反应占牛奶变态反应性疾病的约70%,即1.8%的幼儿, 并且经常是未来特应性疾病和其他食物过敏的预兆。尽管越来越 了解IgE介导的免疫病理学,没有成功的治疗措施, 用来预防或逆转食物过敏。该中心的总体目标是进一步阐明 牛奶过敏的潜在免疫机制,并开发安全有效的治疗形式。 行政核心将通过为该中心提供组织骨干来促进这项努力, 监测临床试验,为所有项目提供生物统计支持,并协调内部的相互作用 以及中心外部,例如NIAID、其他AADCR中心和外部科学审查委员会。 这将通过以下具体目标实现: 目标1:促进项目1-3之间的沟通和互动,协助受试者招募, 保留,并为所有项目提供临床监测,数据库支持和生物统计支持。 目标2:建立一个由食品领域独立专家组成的外部科学审查委员会 过敏和免疫疗法。 目标#3:提供与AADCR中心其他成员沟通的机制。 目标#4:监督本项目与AADCR中心其他成员之间的资源和数据共享。 行政核心将提供管理支持,组织支持,每月内部 项目审查会议,PI和关键人员的季度项目间会议,季度AADCRC 指导委员会电话会议、两年期科学咨询委员会电话会议和 AADCRC PI会议在贝塞斯达。核心将安排住宿[如有必要,例如外部评审员], 为在西奈山举行的会议提供会议室和设备, 报销科学和PI年度会议费用。核心还将与AADCRC指导委员会合作 委员会,以促进作为本提案的一部分收集的数据以及方法、程序的共享 以及与AADCRC网络的其他成员一起为支持这一建议而开发的资源。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Hugh A Sampson其他文献

Standardization of anti-asthma herbal formula MSSM-002 by HPLC chromatographic fingerprint
  • DOI:
    10.1016/s0091-6749(02)81886-3
  • 发表时间:
    2002-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Zhong-Mei Zou;Hugh A Sampson;Xiu-Min Li
  • 通讯作者:
    Xiu-Min Li
The Chinese herbal formula, MSSM-002, can reverse the established Th2 phenotype, which is accompanied with down regulation of the th2 transcription factor GATA-3
  • DOI:
    10.1016/s0091-6749(02)81592-5
  • 发表时间:
    2002-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Xiu-Min Li;Ariel Teper;Zhong-Mei Zou;Kamal D Srivastava;Brian H Schofield;Hugh A Sampson
  • 通讯作者:
    Hugh A Sampson
Detection of milk proteins in dry powder inhalers containing lactose
  • DOI:
    10.1016/s0091-6749(02)81924-8
  • 发表时间:
    2002-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Anna H Nowak-Wegrzyn;Ludmilla Bardina;Kirsten Beyer;Wayne G Shreffler;Hugh A Sampson
  • 通讯作者:
    Hugh A Sampson
Effects of preparation methods on the allergenicity of peanut in a murine model of peanut-induced anaphylaxis
  • DOI:
    10.1016/s0091-6749(02)81676-1
  • 发表时间:
    2002-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Hayf Emeil Al-Mussawir;Kamal D Srivastava;Kirsten Beyer;Jin-Hua Li;Side Li;Wesley Burks;Gary A Bannon;Xiu-Min Li;Hugh A Sampson
  • 通讯作者:
    Hugh A Sampson
Timing of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study
重复肾上腺素给药时间以告知儿科过敏反应观察期:一项回顾性队列研究
  • DOI:
    10.1016/s2352-4642(25)00139-7
  • 发表时间:
    2025-07-01
  • 期刊:
  • 影响因子:
    15.500
  • 作者:
    Timothy E Dribin;Hugh A Sampson;Yin Zhang;Stephanie Boyd;Nanhua Zhang;Kenneth A Michelson;Mark I Neuman;David C Brousseau;Rakesh D Mistry;Stephen B Freedman;Paul L Aronson;Kelly R Bergmann;Brittany Boswell;Sri S Chinta;Wee-Jhong Chua;Ari R Cohen;Joanna S Cohen;Alicia Daggett;Justin R Davis;Julia F Freeman;Seth Woolf
  • 通讯作者:
    Seth Woolf

Hugh A Sampson的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Hugh A Sampson', 18)}}的其他基金

CTSA INFRASTRUCTURE FOR AIDS RESEARCH
CTSA 艾滋病研究基础设施
  • 批准号:
    8364992
  • 财政年份:
    2011
  • 资助金额:
    $ 1.62万
  • 项目类别:
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH
CTSA 儿科研究基础设施
  • 批准号:
    8364991
  • 财政年份:
    2011
  • 资助金额:
    $ 1.62万
  • 项目类别:
CTSA INFRASTRUCTURE FOR AIDS RESEARCH
CTSA 艾滋病研究基础设施
  • 批准号:
    8364993
  • 财政年份:
    2011
  • 资助金额:
    $ 1.62万
  • 项目类别:
CTSA INFRASTRUCTURE FOR CLINICAL TRIALS
CTSA 临床试验基础设施
  • 批准号:
    8364990
  • 财政年份:
    2011
  • 资助金额:
    $ 1.62万
  • 项目类别:
MOUNT SINAI INSTITUTES FOR CLINICAL AND TRANSLATIONAL SCIENCES
西奈山临床和转化科学研究所
  • 批准号:
    8364989
  • 财政年份:
    2011
  • 资助金额:
    $ 1.62万
  • 项目类别:
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH
CTSA 儿科研究基础设施
  • 批准号:
    8173753
  • 财政年份:
    2010
  • 资助金额:
    $ 1.62万
  • 项目类别:
Immunologic Responses to Cow's Milk Proteins in IgE-mediated Cow's Milk Allergy
IgE 介导的牛奶过敏中牛奶蛋白的免疫反应
  • 批准号:
    8034293
  • 财政年份:
    2010
  • 资助金额:
    $ 1.62万
  • 项目类别:
CTSA INFRASTRUCTURE FOR AIDS RESEARCH
CTSA 艾滋病研究基础设施
  • 批准号:
    8173755
  • 财政年份:
    2010
  • 资助金额:
    $ 1.62万
  • 项目类别:
CTSA INFRASTRUCTURE FOR AIDS RESEARCH
CTSA 艾滋病研究基础设施
  • 批准号:
    8173754
  • 财政年份:
    2010
  • 资助金额:
    $ 1.62万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    8022462
  • 财政年份:
    2010
  • 资助金额:
    $ 1.62万
  • 项目类别:

相似海外基金

Psychosocial factors as potential moderators of the association between prenatal stress from the Fort McMurray wildfire and social emotional development in 5-6 year old children
心理社会因素作为麦克默里堡野火产前压力与 5-6 岁儿童社会情绪发展之间关系的潜在调节因素
  • 批准号:
    467237
  • 财政年份:
    2021
  • 资助金额:
    $ 1.62万
  • 项目类别:
    Studentship Programs
Mechanisms of Sustained Selective Attention in 2- to 6- Year-Old Children
2至6岁儿童持续选择性注意力的机制
  • 批准号:
    7739271
  • 财政年份:
    2009
  • 资助金额:
    $ 1.62万
  • 项目类别:
Stage 1 Treatment Development with Homeless Mothers and their 2-6 Year Old Childr
无家可归的母亲及其 2-6 岁儿童的第一阶段治疗发展
  • 批准号:
    7627037
  • 财政年份:
    2009
  • 资助金额:
    $ 1.62万
  • 项目类别:
Stage 1 Treatment Development with Homeless Mothers and their 2-6 Year Old Childr
无家可归的母亲及其 2-6 岁儿童的第一阶段治疗发展
  • 批准号:
    8037547
  • 财政年份:
    2009
  • 资助金额:
    $ 1.62万
  • 项目类别:
Mechanisms of Sustained Selective Attention in 2- to 6- Year-Old Children
2至6岁儿童持续选择性注意力的机制
  • 批准号:
    7921601
  • 财政年份:
    2009
  • 资助金额:
    $ 1.62万
  • 项目类别:
Stage 1 Treatment Development with Homeless Mothers and their 2-6 Year Old Childr
无家可归的母亲及其 2-6 岁儿童的第一阶段治疗发展
  • 批准号:
    8035834
  • 财政年份:
    2009
  • 资助金额:
    $ 1.62万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了