Collaboration on Alcohol Self-Administration in Adolescents and Young Adults

青少年和年轻人自我饮酒方面的合作

• 批准号: 7816912
• 负责人: SEAN Joseph O'CONNOR
• 金额: $ 29.03万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7816912
• 关键词: 21 year old; Address; Adolescent; Age; Alcohol dehydrogenase; Alcohol dependence; Alcoholism; Alcohols; American; Americas; Area; Behavior; Biological Markers; Brain; Candidate Disease Gene; Collaborations; Complement; Computer Assisted; Crossover Design; Development; Disinhibition; Epigenetic Process; Equilibrium; Equipment and supply inventories; Ethanol; Ethanol Metabolism; Family history of; Functional Magnetic Resonance Imaging; Funding; Gender; Genetic; Genotype; German population; Germany; Haplotypes; Hepatic; Impulsivity; Indiana; Infusion procedures; Institution; International; Kinetics; Knowledge; Leadership; Life; Measures; National Institute on Alcohol Abuse and Alcoholism; Participant; Perception; Performance; Pharmacodynamics; Placebos; Population; Preparation; Prosencephalon; Prospective Studies; Recording of previous events; Recruitment Activity; Research; Research Personnel; Research Priority; Resources; Risk; Risk Factors; Sampling; Scanning; Self Administration; Signal Transduction; Symptoms; System; Techniques; Testing; Time; Universities; Work; alcohol effect; alcohol exposure; alcohol use disorder; base; drinking; drinking onset; drug development; frontal lobe; hedonic; medical schools; novel; performance tests; public health relevance; underage drinker; underage drinking; willingness; young adult

DESCRIPTION (provided by applicant): This proposal for an International Collaborative U01 exchanges novel alcohol administration techniques between investigators at the Indiana University School of Medicine and the Technical University of Dresden, Germany, then undertakes research that contributes new knowledge complementing ongoing existing activities at both institutions. The Computer-Assisted Self-administration of Ethanol (CASE) system, invented, developed and validated by the Co-PIs, will be used prospectively in Germany to assess the initial drinking trajectories of 80 adolescents, recruited for a differential risk history of familial alcoholism. The sample will be assessed for symptoms of alcohol use disorders and recent drinking history prior to CASE assessments of alcohol self administration for enjoyment, conducted at ages 16 and 18. The initial slope of drinking trajectories will be computed from changes in CASE performance, and tested for association with the other risk factors. Dresden will also assess the effects alcohol on frontal lobe measures of impulsivity in half the sample population, using the Stop-Signal task performed during fMRI scanning. The time-course of brain exposure to alcohol in the fMRI camera will be nearly identical in every subject, accomplished by an autoclamping system, developed in Indiana. In Indianapolis, the aim is to assess the capacity of CASE to differentiate "liking" from "wanting" alcohol as bases for alcohol self-administration behavior in preparation for drug-development studies. Two CASE paradigms will be compared; one assessing the hedonic impact of alcohol self-administration; the other quantifying the willingness to work for more alcohol. A crossover design in a sample population of 80 young adult drinkers will be employed. CASE performance in each paradigm will be assessed for differential sensitivity to subjective perceptions at the end of a priming interval, and to risk factors for alcohol dependence that include differential history of familial alcoholism, personal recent drinking history, and an inventory of alcohol use disorder symptoms. Indiana will also genotype both German and American sample populations and seek associations between SNP haplotypes in the alcohol dehydrogenase cluster and alcohol metabolism and other risk factors. PUBLIC HEALTH RELEVANCE: This original application directly addresses research priorities valued in PAR-08-004; pharmacodynamics, alcohol genetics and epigenetics, biomarkers of risk, effects of exposure on the adolescent that elucidate the relationship between drinking onset, and the development of alcohol use disorders. The partnership is real and well balanced, and the U01 leadership plan incorporates the collaborative resources of NIAAA.

描述（由申请人提供）：该国际合作U 01提案在印第安纳州大学医学院和德国德累斯顿工业大学的研究人员之间交流新型酒精管理技术，然后进行研究，为补充两家机构正在进行的现有活动提供新的知识。由Co-PI发明、开发和验证的计算机辅助乙醇自我给药（CASE）系统将在德国前瞻性地用于评估80名青少年的初始饮酒轨迹，这些青少年被招募用于家族性酒精中毒的不同风险史。在16岁和18岁时进行的自我饮酒评估之前，将对样本进行酒精使用障碍症状和近期饮酒史评估。饮酒轨迹的初始斜率将根据CASE表现的变化计算，并测试与其他风险因素的关联。德累斯顿还将评估酒精对一半样本人群额叶冲动性测量的影响，使用功能磁共振成像扫描期间执行的停止信号任务。在功能磁共振成像摄像机中，每个受试者的大脑暴露于酒精的时间过程几乎是相同的，这是由印第安纳州开发的自动夹紧系统完成的。在印第安纳波利斯，目的是评估CASE区分“喜欢”和“想要”酒精的能力，作为酒精自我管理行为的基础，为药物开发研究做准备。两个案例范例将进行比较，一个评估自我管理酒精的享乐影响;其他量化的意愿，工作更多的酒精。将采用80名年轻成年饮酒者的样本人群的交叉设计。将评估每个范例中的CASE表现，以确定在启动间隔结束时对主观感知的不同敏感性，以及对酒精依赖的风险因素的不同敏感性，这些风险因素包括不同的家族性酒精中毒史、个人近期饮酒史和酒精使用障碍症状清单。印第安纳州还将对德国和美国样本人群进行基因分型，并寻找酒精脱氢酶簇中SNP单倍型与酒精代谢和其他风险因素之间的关联。 公共卫生关系：该原始申请直接解决了PAR-08-004中重视的研究优先事项;药效学，酒精遗传学和表观遗传学，风险生物标志物，暴露对青少年的影响，阐明饮酒发作与酒精使用障碍之间的关系。这种伙伴关系是真实的，并且平衡良好，U 01领导计划纳入了NIAAA的协作资源。