DEVELOPING A PARADIGM TO DETECT SENSITIVITY TO THE RATE OF CHANGE OF BRAC

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our lab specializes in prescribing the time course of brain exposure to alcohol. We have demonstrated that the human brain responds to both the concentration of alcohol and the time since exposure of the brain to alcohol began (acute adaptation to alcohol). This project begins our study of the brain's response to the rate of change with respect to time of alcohol. In this preliminary developmental study, we seek the optimum combination of multi-segment, constant slope prescriptions for the BrAC to be used in an eventual scientific study, and to construct a battery of dependent measures of brain function that can be measured very frequently, since BrAC will be changing rapidly throughout the experiment.