EFFECTS OF ASPIRIN IN GESTATION AND REPRODUCTION (EAGER)

阿司匹林对妊娠和生殖的影响（EAGER）

• 批准号: 8151576
• 金额: $ 20.42万
• 依托单位: UNIVERSITY OF HAIFA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2012-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8151576
• 关键词: Affect; Age; Aspirin; Blood flow; Couples; Dose; Endometrial; Epidemiology; Evaluation; Folic Acid; Frustration; Future; Goals; Human Chorionic Gonadotropin; Incidence; Infant; Infertility; Intervention; Intramural Research; Laboratories; Live Birth; Measures; Morbidity - disease rate; National Institute of Child Health and Human Development; Nature; Outcome; Phase; Placebos; Population; Pregnancy; Pregnancy Outcome; Pregnancy loss; Process; Recruitment Activity; Relative (related person); Reproduction; Sampling; Serum; Site; Spontaneous abortion; Thick; United States; Urine; Validity of Self Report; Woman; adverse outcome; experience; implantation; mortality; multi-site trial; prevent; randomized trial; repository

Despite the fundamental nature of reproduction, for many it is a process fraught with frustration, inefficiency and imperfections. Infertility affects 10 to 15 percent of couples attempting to conceive. Among all women who conceive, the incidence of spontaneous miscarriage has been estimated at between 15 and 31 percent, and in many cases the cause is unknown. Additionally, of the four million infants born each year in the United States, between eight and 15 percent will be born prematurely and as a result, will experience higher morbidity and mortality, compared with full-term infants. . An intervention with even a small relative effect on preventing the occurrence of any of these adverse outcomes has great implications at the population level because of the large potential attributable benefit. For this reason, the Epidemiology Branch of DESPR Intramural research at the NICHD is conducting a multi-site randomized trial to evaluate the effect of daily low-dose aspirin and folic acid, compared folic acid and placebo alone, on reproduction at all phases, beginning at preconception and continuing throughout pregnancy. The trial will assess the effects of aspirin on each of the phases, including implantation and live birth. The trial has the goal of recruiting and completing the intervention in a sample of at least 1,600 women, age 18-40, who have previously experienced one or two pregnancy losses and who are actively trying to conceive.

尽管生殖的本质是基本的，但对许多人来说，这是一个充满挫折、低效和不完美的过程。不孕不育会影响10%到15%的试图怀孕的夫妇。在所有怀孕的女性中，自发流产的发生率估计在15%到31%之间，在许多情况下，原因尚不清楚。此外，在美国每年出生的400万婴儿中，有8%到15%的婴儿将早产，因此，与足月婴儿相比，他们的发病率和死亡率更高。。即使对预防这些不利后果的发生有很小的相对效果的干预措施，也会在人口一级产生重大影响，因为潜在的可归因性好处很大。出于这个原因，NICHD的Despr墙内研究流行病学分部正在进行一项多点随机试验，以评估每日小剂量阿司匹林和叶酸对生殖的影响，比较叶酸和安慰剂对生殖的影响，从怀孕前开始，一直持续到怀孕。这项试验将评估阿司匹林在每个阶段的影响，包括植入和活产。这项试验的目标是招募至少1600名年龄在18-40岁之间的女性，并完成干预措施，这些女性以前曾经历过一到两次怀孕失败，并且正在积极尝试怀孕。