Studies of Chemical Disposition in Animals

三种离子液体开始吸收、分布、代谢和消除，这些离子液体在脱脂应用中被推广为卤化溶剂的替代品。正在进行口服和皮肤研究以支持 NTP 亚慢性毒性研究。 TBBPA 和 TBBPA-DBPE 在电路板和聚碳酸酯-丙烯腈-丁二烯-苯乙烯塑料中用作阻燃剂。工人广泛接触这些化学品，消费者也可能接触这些化学品。特别强调确定 TBBPA-DBPE 是否代谢产生 2,3-二溴丙醚（一种已知的动物致癌物）。目前的研究还包括通过口服和皮肤途径进行离子液体的生物利用度研究。 关键词 代谢物鉴定；核磁共振；高效液相色谱法；质谱分析；吸收；分配;消除；动力学; LSC；体内;体外;放射性标记化合物；真皮；灌胃；四、吸入；质量平衡；离子液体；四溴双酚A；四溴双酚A-2,3二溴丙醚；离子液体

Absorption, distribution, metabolism and elimination were begun on three ionic liquids that are promoted as replacements for halogenated solvents in degreasing applications. Oral and dermal studies are being conducted in support of the NTP sub-chronic toxicity studies. TBBPA and TBBPA-DBPE are used as flame retardents in circuit boards and polycarbonate-acrylonitrile-butadiene-styrene plastics. There is widespread worker exposure to these chemicals and possible consumer exposure. Special emphasis is being made to determine if TBBPA-DBPE is metabolized to produce 2,3-dibromopropyl ether, a known animal carcinogen. Present studies also include bioavailability studies of ionic liquids by the oral and dermal routes. Keywords Metabolite identification; NMR; HPLC; Mass spectrometry; Absorption; Distribution; Elimination; Kinetics; LSC; In vivo; In vitro; Radiolabeled compounds; Dermal; Gavage; IV; Inhalation; Mass balance; Ionic liquids; tetrabromobisphenol A; tetrabromobisphenol A-2,3 dibromopropyl ether; ionic liquids