Studies of Chemical Disposition in Animals

动物化学处置研究

• 批准号: 7934765
• 负责人: GLENN I SIPES
• 金额: $ 49.62万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7934765
• 关键词: Studies; Chemical; Disposition; Animals

Absorption, distribution, metabolism and elimination were begun on three ionic liquids that are promoted as replacements for halogenated solvents in degreasing applications. Oral and dermal studies are being conducted in support of the NTP sub-chronic toxicity studies. TBBPA and TBBPA-DBPE are used as flame retardents in circuit boards and polycarbonate-acrylonitrile-butadiene-styrene plastics. There is widespread worker exposure to these chemicals and possible consumer exposure. Special emphasis is being made to determine if TBBPA-DBPE is metabolized to produce 2,3-dibromopropyl ether, a known animal carcinogen. Present studies also include bioavailability studies of ionic liquids by the oral and dermal routes. Keywords Metabolite identification; NMR; HPLC; Mass spectrometry; Absorption; Distribution; Elimination; Kinetics; LSC; In vivo; In vitro; Radiolabeled compounds; Dermal; Gavage; IV; Inhalation; Mass balance; Ionic liquids; tetrabromobisphenol A; tetrabromobisphenol A-2,3 dibromopropyl ether; ionic liquids

研究了三种离子液体在脱脂中的吸附、分布、代谢和消除作用，提出了三种离子液体作为卤代溶剂的替代品。正在进行口服和皮肤研究，以支持NTP的亚慢性毒性研究。TBBPA和TBBPA-DBPE用作电路板和聚碳酸酯-丙烯腈-丁二烯-苯乙烯塑料的阻燃剂。工人普遍接触到这些化学品，消费者也可能接触到这些化学品。特别强调的是确定TBBPA-DBPE是否被代谢成2，3-二溴丙基醚，这是一种已知的动物致癌物。目前的研究还包括离子液体的口服和经皮途径的生物利用度研究。 代谢物鉴定；核磁共振；高效液相色谱；质谱学；吸收；分布；消除；动力学；LSC；体内；体外；放射性标记化合物；真皮；灌胃；IV；吸入；质量平衡；离子液体；四溴双酚A；四溴双酚A-2，3-二溴丙基醚；离子液体