STUDIES OF CHEMICAL DISPOSITION IN MAMMALS

国家毒理学计划(NTP)寻求评估风险 与可能的急性、反复或慢性接触有关 通过研究各种生物效应来研究化学物质 包括因长期接触而被指控的致癌性。研究 的毒性机制和化学物质的去向(S) 完整的动物是NTP研究范围的组成部分 用来描述化学毒性的。数据获取自 对完好动物体内化学物质命运的研究，如上所述 在本合同中，通过提供以下内容支持NTP目标 从实验室推断风险的基础 从动物到人类都是如此。 这个项目的目标有两个方面。每项研究都是专门设计的 为了解决这些独特的物理和化学特性， 所研究的化合物以及提供的数据将允许 各化学级的结构表征。 这些研究也可能是为了解决一种 或更多因素，如性别、物种、年龄、性别或路线 暴露于所研究的化学物质的命运和/或毒性(S) 以及这些数据对人类健康评估的意义 风险。因此，这些研究的直接目标是 更准确地确定NTP生物测定研究的剂量。 长期目标是积累数据，以便 允许对这些结构活动进行更好的评估 决定化学吸收、新陈代谢和 实验动物的性情。的最终目标是 该项目将提供数据，以便进行更好的评估 与人类接触化学品有关的风险 在环境、家庭和工作场所。

The National Toxicology Program (NTP) seeks to assess risks associated with possible acute, repeated or chronic exposure to chemicals by investigating a variety of biological effects including carcinogenicity indiced on chronic exposure. Studies of the mechanism(s) of toxicity and the fate of chemicals in intact animals are an integral part of the range of NTP studies designed to characterize chemical toxicity. Data obtained from studies of the fate of chemicals in intact animals, as described in this contract, support NTP objectives by providing the fundation on which extrapolations of risks from laboratory animals to humans are based. Objectives of this project are two fold. Each study is designed to address those physical and chemical properties unique to the compound studied as well as to provide data that will permit structural characterization of the respective chemical calss. These studies may also be designed to address the impact of one or more factors such as does, species, age, sex or route of exposure on the fate and/or toxicity of the chemical(s) studied and thesignificance of thede data to assessments of human helath risks. Thus, the immediate objective of these studies is to determine more accurately the doses for NTP bioassay studies. The long-range objective is the accumulation of data that will permit better assessments of those structure-activity relationships that determine chemical absorption, metabolism and disposition in laboratory animals. The ultimate objective of this project is to provide data that permit better assessments of risks associated with human exposure to chemicals encountered in the environment, home and workplace.