STUDIES OF CHEMICAL DISPOSITION IN MAMMALS

哺乳动物化学处置的研究

• 批准号: 2722839
• 负责人: A R JEFFCOAT
• 金额: $ 109.61万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2002-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2722839
• 关键词: Animalia; bioassay; chemical carcinogen; chemical structure function; data collection methodology /evaluation; dosage; environmental contamination; environmental toxicology; toxicant screening; toxin metabolism

The National Toxicology Program (NTP) seeks to assess risks associated with possible acute, repeated or chronic exposure to chemicals by investigating a variety of biological effects including carcinogenicity indiced on chronic exposure. Studies of the mechanism(s) of toxicity and the fate of chemicals in intact animals are an integral part of the range of NTP studies designed to characterize chemical toxicity. Data obtained from studies of the fate of chemicals in intact animals, as described in this contract, support NTP objectives by providing the fundation on which extrapolations of risks from laboratory animals to humans are based. Objectives of this project are two fold. Each study is designed to address those physical and chemical properties unique to the compound studied as well as to provide data that will permit structural characterization of the respective chemical calss. These studies may also be designed to address the impact of one or more factors such as does, species, age, sex or route of exposure on the fate and/or toxicity of the chemical(s) studied and thesignificance of thede data to assessments of human helath risks. Thus, the immediate objective of these studies is to determine more accurately the doses for NTP bioassay studies. The long-range objective is the accumulation of data that will permit better assessments of those structure-activity relationships that determine chemical absorption, metabolism and disposition in laboratory animals. The ultimate objective of this project is to provide data that permit better assessments of risks associated with human exposure to chemicals encountered in the environment, home and workplace.

国家毒理学计划（NTP）旨在评估风险 与可能的急性、反复或慢性接触有关 通过研究各种生物效应， 包括慢性接触的致癌性。 研究 化学品的毒性机制和最终归宿 完整的动物是NTP研究范围的组成部分 用来描述化学毒性 获得的数据 研究化学品在完整动物体内的命运，如所述 在本合同中，通过提供 从实验室推断风险的基础 动物对人类的影响是基于 该项目的目标有两个方面。 每项研究都是为了 以解决这些独特的物理和化学性质， 研究化合物以及提供数据，将允许 相应化学类别的结构表征。 这些研究也可能旨在解决一个 或更多的因素，如性别，物种，年龄，性别或途径， 暴露对所研究化学品的转归和/或毒性的影响 以及这些数据对人体健康评估的意义 风险 因此，这些研究的直接目标是 更准确地确定NTP生物测定研究的剂量。 长期目标是积累数据， 可以更好地评估这些结构-活性 决定化学吸收、代谢和 在实验室动物中的处置。 的最终目标 该项目旨在提供数据，以便更好地评估 与人类接触化学品有关的风险 在环境，家庭和工作场所。