Molecular Libraries Small Molecule Repository

分子图书馆小分子库（MLSMR）是美国国立卫生研究院（NIH）分子图书馆路线图倡议的一个组成部分，用于创建NIH小分子图书馆和筛选中心。小分子库将为公共部门的生物医学研究人员提供可用作化学探针的小有机分子，以更深入地研究细胞通路，并将提供探索细胞主要成分在健康和疾病中的功能的新方法。为了提供这些益处，小分子库必须包含足够数量的不同化合物以筛选大量可能的新活性和应用。为了建立这样一个库，MLSMR将建立以获取，维护和分发来自政府，学术，工业和商业来源的已知和未知活动的多达500，000种化学多样的小分子。随着时间的推移，该集合将被扩展和修改，以包括能够与越来越多和多样性的生物分子靶结构域相互作用的化合物。这些文库的开发将为研究从单细胞到整个生物体的生物系统中的分子事件、途径和网络提供探针。MLSMR将获取化合物，进行质量控制分析，并以便于获取和跟踪的方式储存化合物，并将化合物保持在最佳条件下。MLSMR将这些化合物以平板组的形式分发给高通量筛选中心的分子库网络进行生物学评价。

The Molecular Libraries Small Molecule Repository (MLSMR) is a component of the National Institutes of Health (NIH) Roadmap Molecular Libraries initiative for the creation of an NIH small molecule library and screening centers. The Small Molecule Repository will offer public sector biomedical researchers access to small organic molecules that can be used as chemical probes to study cellular pathways in greater depth and will provide new ways to explore the functions of major components of the cell in health and disease. In order to provide these benefits, the library of small molecules must contain a sufficient number of diverse compounds to be screened for a large number of possible new activities and applications. To build such a library, the MLSMR will be established to acquire, maintain, and distribute a collection of up to 500,000 chemically diverse small molecules of both known and unknown activities from government, academic, industry and commercial sources. Over time, this collection will be expanded and modified to include compounds that are capable of interacting with an increasing number and diversity of biomolecular target domains. The development of such libraries will provide probes for studying molecular events, pathways, and networks in biologic systems that span the scale from single cells to whole organisms. The MLSMR will acquire the compounds, conduct quality control analyses, and store them in manner that allows easy access and tracking and maintains the compounds under optimal conditions. The MLSMR will distribute these compounds in plated sets to the Molecular Libraries network of high-throughput screening centers for biological evaluation.