ARIC

阿里克

• 批准号: 7789067
• 负责人: LLOYD E CHAMBLESS
• 金额: $ 3.6万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-07-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7789067
• 关键词: ARIC

Over the past 20 years, the Atherosclerosis Risk In Communities (ARIC) Study has provided important new information on risk factors for atherosclerosis and its progression, on risk factors for coronary heart disease and stroke, and on trends in community rates of cardiovascular disease. We herein propose continuation of ARIC from 2005 to 2012. There are separate proposals for each ARIC Field Center, the Coordinating Center, and the Laboratories. Our aims for renewal in response to the ARIC RFPs are: 1. Completion of 23 years of coronary heart disease (CHD) surveillance in the four ARIC communities, permitting detection of trends in CHD Incidence, case fatality, and mortality in racesex-specific subgroups. For 2005-2009, CHD Surveillance will expand to 75-84 year olds, and inpatient heart failure (55 years and older) and outpatient heart failure surveillance (65 years and older) will be undertaken. 2. Follow-up of ARIC's previously examined cohort for cardiovascular disease (CVD) morbidity and mortality over 23 years, to identify factors related to Incident CHD, stroke, and for 2005-2009, heart failure. 3. Identification and characterization of novel genetic and biochemical risk factors for CVD using stored blood, urine, and DNA samples from available subclinical disease cases, available and newly-occurring CVD cases and control subjects, and subgroups with rapid progression of subclinical disease. The genes and analytes to be measured will be identified via a pathway approach to atherosclerosis and CVD. An extension will enable ARIC to continue to (1) address community trends in CVD and (2) make use of its valuable database and biosample resource to address new questions on the etiology of cardiovascular disease. The Collaborative Studies Coordinating Center has served as the ARIC coordinating center (CC) and will continue providing the overall operation and scientific coordination for the ARIC study with special emphasis on statistical methodology. CC staff will participate in all the ARIC committees and subcommittees, will coordinate conference calls and take minutes. The CC staff will actively participate in writing manuscripts as lead and co-authors and provide statistical advice, analyses and review when needed. The CC will maintain and participate in development of manuals, forms, and instructions. Training sessions will be coordinated by CC staff. Data management, including systems for data entry and systems to prepare data files for analyses, will be maintained and created for HF and mortality and morbidity classification (MMCC) for CHD and HF. All MMCC activities will be coordinated by CC. Quality control reports will be prepared and monitoring visits to field centers and central agencies will be on going. The CC will respond to needs of community surveillance (CHD and HF), AFU, and laboratory studies (including case-cohort studies) as issues arise. The CC will maintain and update two websites for ARIC. The CC will coordinate ARIC's efforts to disseminate data to investigators within and outside the ARIC scientists.

在过去的 20 年里，社区动脉粥样硬化风险 (ARIC) 研究提供了有关动脉粥样硬化及其进展的危险因素、冠心病和中风的危险因素以及社区心血管疾病发病率趋势的重要新信息。我们在此建议 ARIC 从 2005 年延续到 2012 年。每个 ARIC 现场中心、协调中心和实验室都有单独的提案。 我们响应 ARIC RFP 的更新目标是： 1. 在四个 ARIC 社区完成 23 年的冠心病 (CHD) 监测，从而能够检测特定种族亚组的冠心病发病率、病死率和死亡率的趋势。 2005-2009年，CHD监测范围将扩大到75-84岁，并将开展住院心力衰竭患者（55岁及以上）和门诊心力衰竭患者（65岁及以上）监测。 2. 对 ARIC 先前检查的 23 年心血管疾病 (CVD) 发病率和死亡率队列进行随访，以确定与 CHD、中风以及 2005-2009 年心力衰竭事件相关的因素。 3. 使用来自现有亚临床疾病病例、现有和新发CVD病例和对照受试者以及亚临床疾病快速进展亚组的储存血液、尿液和DNA样本，鉴定和表征CVD的新遗传和生化危险因素。待测量的基因和分析物将通过动脉粥样硬化和心血管疾病的途径方法进行鉴定。 延期将使 ARIC 能够继续（1）解决 CVD 的社区趋势，（2）利用其宝贵的数据库和生物样本资源来解决有关心血管疾病病因学的新问题。 合作研究协调中心已担任ARIC协调中心（CC），并将继续为ARIC研究提供整体运作和科学协调，特别强调统计方法。 CC 工作人员将参加所有 ARIC 委员会和小组委员会，协调电话会议并记录会议记录。 CC工作人员将作为主要作者和共同作者积极参与稿件的撰写，并在需要时提供统计建议、分析和审查。 CC 将维护并参与手册、表格和说明的制定。培训课程将由 CC 工作人员协调。将为心力衰竭以及冠心病和心力衰竭的死亡率和发病率分类（MMCC）维护和创建数据管理，包括数据输入系统和准备分析数据文件的系统。 MMCC 的所有活动将由 CC 协调。将编写质量控制报告，并对现场中心和中央机构进行监督访问。当出现问题时，CC 将响应社区监测（CHD 和 HF）、AFU 和实验室研究（包括病例队列研究）的需求。 CC 将为 ARIC 维护和更新两个网站。 CC 将协调 ARIC 向 ARIC 内部和外部科学家的调查人员传播数据的工作。