THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A

社区动脉粥样硬化风险 (ARIC) 研究 - 现场中心 - 任务令 01，任务区 A

• 批准号: 10620984
• 负责人: JOSEF CORESH
• 金额: $ 95.93万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-11-15 至 2022-11-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10620984
• 关键词: Adult; African American; Amyloid deposition; Ancillary Study; Area; Atherosclerosis; Atherosclerosis Risk in Communities; Atrial Fibrillation; Biochemical; Biological Assay; Blood Vessels; Blood specimen; Brain; Candidate Disease Gene; Cardiovascular Diseases; Case-Control Studies; Clinical; Cognition; Cohort Studies; Collaborations; Communities; Contracts; Coronary heart disease; County; Cryopreservation; DNA; Data; Data Collection; Dementia; Diabetes Mellitus; EFRAC; Electrocardiogram; Environmental Risk Factor; Event; Fostering; Funding; Genetic; Genome Scan; Geographic Locations; Goals; Grant; Heart failure; Hospitalization; Injury; Investigation; Lymphocyte; Monitor; Myocardial Infarction; Natural History; Participant; Policies; Process; Prospective cohort study; Publications; Research Personnel; Risk Factors; Subgroup; Technology; United States National Institutes of Health; Ventricular Dysfunction; Vital Status; Washington; aged; arterial stiffness; base; caucasian American; clinical development; clinical examination; clinical predictors; cohort; coronary artery calcification; data sharing; follow-up; member; middle age; mortality; novel; preservation; recruit; residence; rural setting; suburb; trend

The Atherosclerosis Risk in Communities (ARIC) Study was initiated in 1985 with two components: community-based surveillance and a prospective cohort study. The community surveillance aimed to monitor trends in hospitalized myocardial infarction (MI), fatal coronary heart disease (CHD) in four U.S. communities: Forsyth County, NC; Jackson, MS; suburbs of Minneapolis, MN; and Washington County, MD. Surveillance for hospitalized heart failure (HF) events was added in 2005. The communities were selected to provide data across four (4) geographic locations with a range of mortality rates, in urban, suburban, and rural settings. The cohort study aimed to investigate the risk factors for and natural history of atherosclerosis and development of clinical atherosclerosis in middle-aged white or African American adults from the same communities. The study recruited in 15,792 white or African American participants initially aged 45-64 years and selected participants received triennial clinical exams over the first ten years of the study (1987-1989, 1990-1992, 1993-1995, and 1996-1998). The clinical exam in 2011-13 was conducted on over 6,500 participants 69-89 years with a focus on characterizing heart failure stages in community-dwelling participants and enabling identification of genetic and environmental factors leading to ventricular dysfunction and vascular stiffness. These data provided the basis for several ancillary studies covering a breadth of topics. The clinical exam in 2018-19 on almost 3,600 participants 75 years and older supported exam components from 12 NIH grant-funded ancillary studies on topics including progression of Heart Failure with preserved Ejection Fraction (HFpEF), coronary artery calcification, atrial fibrillation burden detected by novel continuous ECG monitoring technology, diabetes, dementia, brain amyloid deposition, and changes in arterial stiffness and cognition. Participation of the surviving cohort was 91, 82, 74, 65, and 50% at each of the respective follow-up examinations. Blood samples have been assayed for putative biochemical risk factors and stored for case-control studies. DNA has been extracted and lymphocytes cryopreserved (for possible immortalization) for study of candidate genes, genome-wide scanning, expression, and other –omics investigations. Since baseline, cohort members have also been contacted every 12 months (and every 6 months since 2012) to obtain information on vital status, current residence, major illness or injury, and hospitalizations occurring between contacts to identify clinical cardiovascular disease (CVD) events. Cohort contact was 78% at the last completed follow-up period. Findings have been presented in over 2,600 publications as of 2021.

社区动脉粥样硬化风险研究（ARIC）于1985年启动，由两部分组成：基于社区的监测和前瞻性队列研究。社区监测旨在监测美国四个社区的住院心肌梗死（MI）、致死性冠心病（CHD）趋势：福赛斯县，NC;杰克逊，MS;明尼阿波利斯郊区，MN;和华盛顿县，MD。2005年增加了对住院心力衰竭（HF）事件的监测。选择这些社区是为了提供城市、郊区和农村四（4）个地理位置的死亡率数据。该队列研究旨在调查来自同一社区的中年白色或非洲裔美国人中动脉粥样硬化的危险因素和自然史以及临床动脉粥样硬化的发展。该研究招募了15，792名最初年龄在45-64岁之间的白色或非洲裔美国人参与者，并选择参与者在研究的前十年（1987-1989，1990-1992，1993-1995和1996-1998）接受三年一次的临床检查。2011-13年的临床检查对6，500多名69-89岁的参与者进行，重点是描述社区居住参与者的心力衰竭阶段，并识别导致心室功能障碍和血管僵硬的遗传和环境因素。这些数据为涵盖广泛主题的几项辅助研究提供了基础。2018-19年对近3，600名75岁及以上参与者进行的临床检查支持来自12项NIH资助的辅助研究的检查组成部分，主题包括射血分数保留的心力衰竭（HFpEF）进展，冠状动脉钙化，通过新型连续ECG监测技术检测的房颤负担，糖尿病，痴呆，脑淀粉样蛋白沉积，以及动脉硬化和认知的变化。在每次相应的随访检查中，存活队列的参与率分别为91%、82%、74%、65%和50%。血液样本已被测定推定的生化危险因素，并储存用于病例对照研究。提取DNA并冷冻保存淋巴细胞（用于可能的永生化），用于候选基因的研究、全基因组扫描、表达和其他组学研究。自基线起，还每12个月（自2012年起每6个月）联系一次队列成员，以获得有关生命状态、当前居住地、重大疾病或损伤以及联系人之间发生的住院情况的信息，以确定临床心血管疾病（CVD）事件。在末次完成的随访期，队列联系率为78%。截至2021年，研究结果已在超过2，600份出版物中发表。