Nutritional Epidemiology of Lower Urinary Tract Symptoms

描述(由申请者提供)：该项目利用波士顿地区社区健康(BACH)研究中收集的饮食数据，以社区为基础的多样化随机样本，帮助填补妇科症状营养流行病学方面的知识空白。下尿路症状(LUT)，包括储存、排尿和排尿后症状，是日常困扰和负担的来源，并严重降低数百万成年人的生活质量-仅在美国就超过3000万男性和女性。必须挑战曾经盛行的范式，即这些症状是衰老的一个不可避免的方面，不受生活方式选择的改变的影响，这项研究响应了全国范围内的呼吁，即研究确定这些症状的风险因素。最容易改变的生活方式因素之一是饮食--即每天摄入的营养素和饮料，它具有提供缓解和预防以及参与LUTS的发生和发展的高度可信的机制。本研究调查了男性和女性的碳水化合物、蛋白质、脂肪、钠、胆固醇、维生素C、维生素A、类胡萝卜素、钙和锌的摄入量与LUTS、排尿症状、尿后症状和储存症状(包括紧迫感和尿失禁)之间的横向和纵向联系。它还检查了膳食和补充微营养素的来源，以及不同摄入量类别的剂量反应趋势。不同饮料类型的摄入量也被前瞻性地检查，以验证关于咖啡因、酸性或碳酸饮料影响的轶事证据。巴赫获得了一份完整的有效饮食评估，其中考虑了食物消费的种族差异，连同关于泌尿症状、社会人口学、人体测量学、健康状况、药物和补充剂使用的深入数据，提供了一个独特的具有成本效益的机会，对男性和女性的泌尿症状中营养素和饮料的作用进行多变量分析。公共卫生相关性：7.项目简介这项研究将采用横断面和前瞻性队列研究设计方法，在基于人群的不同男性和女性样本中，调查大量营养素、微量营养素、液体的摄入量和下尿路症状之间的关系。将对下尿路症状进行全面检查，并将其归类为存储症状，包括尿急和尿失禁、排尿症状和排尿后症状。

DESCRIPTION (provided by applicant): This project utilizes dietary data that was collected as part of the Boston Area Community Health (BACH) study to help fill knowledge gaps in the nutritional epidemiology of urogynecologic symptoms in a diverse, random community-based sample. Lower urinary tract symptoms (LUTS), including storage, voiding and post micturition symptoms, are a source of daily bother and burden and profoundly lower the quality of life of millions of adults - over 30 million men and women in the US alone. The once prevailing paradigm that these symptoms are an inevitable aspect of aging, unaffected by modification of lifestyle choices, must be challenged, and this study responds to nation-wide calls for research to identify risk factors for these symptoms. One of the most readily modifiable lifestyle factors that holds highly plausible mechanisms of offering relief and prevention, as well as being involved in the initiation and progression, of LUTS is diet - i.e., the nutrients and beverages consumed daily. This study examines the cross-sectional and longitudinal associations between intakes of carbohydrate, protein, types of fat, sodium, cholesterol, vitamin C, vitamin A, carotenoids, calcium and zinc, and LUTS, voiding symptoms, post micturition symptoms, and storage symptoms, including urgency and urinary incontinence, separately in men and women. It also examines dietary versus supplemental sources of micronutrients and dose-response trends across categories of intake. Intakes of various beverage types are also examined prospectively to verify anecdotal evidence regarding effects of caffeine, acidic or carbonated beverages. BACH obtained a complete validated dietary assessment that takes into account ethnic variation in food consumption, which, together with in-depth data on urologic symptoms, sociodemographics, anthropometrics, health status, medication and supplement usage, provides a unique cost-efficient opportunity to conduct multivariate analyses of the role of nutrients and beverages in urologic symptoms among men and women. PUBLIC HEALTH RELEVANCE: 7. PROJECT NARRATIVE This study will investigate the associations between intakes of macronutrients, micronutrients, fluids and lower urinary tract symptoms in a diverse, population-based sample of men and women using both cross- sectional and prospective cohort study design methodologies. Lower urinary tract symptoms will be examined both overall and also grouped as storage symptoms, including urgency and urinary incontinence, voiding symptoms, and post micturition symptoms.